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Safety and pharmacodynamics of dalazatide, a Kv1.3 channel inhibitor, in the treatment of plaque psoriasis: A randomized phase 1b trial

PloS one, 2017-07, Vol.12 (7), p.e0180762-e0180762

2017

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Atrial‐like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial‐selective pharmacology

EMBO molecular medicine, 2015-04, Vol.7 (4), p.394-410

2015

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Towards a Structural View of Drug Binding to hERG K+ Channels

Trends in pharmacological sciences (Regular ed.), 2017-10, Vol.38 (10), p.899-907

2017

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An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel

Journal of pharmacological and toxicological methods, 2016-09, Vol.81 (C), p.251-262

2016

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Atrial-selective K + channel blockers: potential antiarrhythmic drugs in atrial fibrillation?

Canadian journal of physiology and pharmacology, 2017-11, Vol.95 (11), p.1313

Ravens, Ursula

2017

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Multiple targets for flecainide action: implications for cardiac arrhythmogenesis

British journal of pharmacology, 2018-04, Vol.175 (8), p.1260-1278

2018

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A potent and selective peptide blocker of the Kv1.3 channel: prediction from free-energy simulations and experimental confirmation

PloS one, 2013-11, Vol.8 (11), p.e78712

2013

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Large-conductance, calcium-activated potassium channels: structural and functional implications

Pharmacology & therapeutics (Oxford), 2006-04, Vol.110 (1), p.103-116

2006

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High-throughput electrophysiological assays for voltage gated ion channels using SyncroPatch 768PE

PloS one, 2017-07, Vol.12 (7), p.e0180154-e0180154

2017

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A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias

The Journal of pharmacology and experimental therapeutics, 2013-01, Vol.344 (1), p.23

2013

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Computational assessment of drug‐induced effects on the electrocardiogram: from ion channel to body surface potentials

British journal of pharmacology, 2013-02, Vol.168 (3), p.718-733

2013

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Discovery of Novel TASK-3 Channel Blockers Using a Pharmacophore-Based Virtual Screening

International journal of molecular sciences, 2019-08, Vol.20 (16), p.4014

2019

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Alternative Targets for Modulators of Mitochondrial Potassium Channels

Molecules (Basel, Switzerland), 2022-01, Vol.27 (1), p.299

2022

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A Computational Method for Unveiling the Target Promiscuity of Pharmacologically Active Compounds

Angewandte Chemie (International ed.), 2017-09, Vol.56 (38), p.11520-11524

International ed. in English, 2017

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Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block

PloS one, 2016-12, Vol.11 (12), p.e0163619-e0163619

2016

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Kv1.3 in the spotlight for treating immune diseases

Expert opinion on therapeutic targets, 2024, Vol.28 (1-2), p.67-82

2024

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Construction of an integrated database for hERG blocking small molecules

PloS one, 2018-07, Vol.13 (7), p.e0199348

2018

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PAP-1 ameliorates DSS-induced colitis with involvement of NLRP3 inflammasome pathway

International immunopharmacology, 2019-10, Vol.75, p.105776-105776, Article 105776

2019

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BcsTx3 is a founder of a novel sea anemone toxin family of potassium channel blocker

The FEBS journal, 2013-10, Vol.280 (19), p.4839-4852

2013

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Mechanisms of gefitinib-induced QT prolongation

European journal of pharmacology, 2021-11, Vol.910, p.174441-174441, Article 174441

2021

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The Small Conductance Calcium-Activated Potassium Channel Inhibitors NS8593 and UCL1684 Prevent the Development of Atrial Fibrillation Through Atrial-Selective Inhibition of Sodium Channel Activity

Journal of cardiovascular pharmacology, 2020-08, Vol.76 (2), p.164

2020

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High-potency block of Kir4.1 channels by pentamidine: Molecular basis

European journal of pharmacology, 2017-11, Vol.815, p.56-63

2017

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Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block

PloS one, 2020-11, Vol.15 (11), p.e0241362-e0241362

2020

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Emerging therapeutic targets in the short QT syndrome

Expert opinion on therapeutic targets, 2018-05, Vol.22 (5), p.439-451

2018

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KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting

Nature communications, 2016-10, Vol.7 (1), p.12795-13, Article 12795

2016

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Safety and pharmacodynamics of dalazatide, a Kv1.3 channel inhibitor, in the treatment of plaque psoriasis: A randomized phase 1b trial

Atrial‐like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial‐selective pharmacology

Towards a Structural View of Drug Binding to hERG K+ Channels

An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel

Atrial-selective K + channel blockers: potential antiarrhythmic drugs in atrial fibrillation?

Multiple targets for flecainide action: implications for cardiac arrhythmogenesis

A potent and selective peptide blocker of the Kv1.3 channel: prediction from free-energy simulations and experimental confirmation

Large-conductance, calcium-activated potassium channels: structural and functional implications

High-throughput electrophysiological assays for voltage gated ion channels using SyncroPatch 768PE

A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias

Computational assessment of drug‐induced effects on the electrocardiogram: from ion channel to body surface potentials

Discovery of Novel TASK-3 Channel Blockers Using a Pharmacophore-Based Virtual Screening

Alternative Targets for Modulators of Mitochondrial Potassium Channels

A Computational Method for Unveiling the Target Promiscuity of Pharmacologically Active Compounds

Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block

Kv1.3 in the spotlight for treating immune diseases

Construction of an integrated database for hERG blocking small molecules

PAP-1 ameliorates DSS-induced colitis with involvement of NLRP3 inflammasome pathway

BcsTx3 is a founder of a novel sea anemone toxin family of potassium channel blocker

Mechanisms of gefitinib-induced QT prolongation

The Small Conductance Calcium-Activated Potassium Channel Inhibitors NS8593 and UCL1684 Prevent the Development of Atrial Fibrillation Through Atrial-Selective Inhibition of Sodium Channel Activity

High-potency block of Kir4.1 channels by pentamidine: Molecular basis

Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block

Emerging therapeutic targets in the short QT syndrome

KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting

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