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Atrial‐like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial‐selective pharmacology

EMBO molecular medicine, 2015-04, Vol.7 (4), p.394-410

2015

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Effect of selective IK,ACh inhibition by XAF‐1407 in an equine model of tachypacing‐induced persistent atrial fibrillation

British journal of pharmacology, 2020-08, Vol.177 (16), p.3778-3794

2020

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Rheumatic Heart Disease Screening by Echocardiography The Inadequacy of World Health Organization Criteria for Optimizing the Diagnosis of Subclinical Disease

Circulation (New York, N.Y.), 2009-08, Vol.120 (8), p.663-668

2009

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Kv4 Potassium Channels Form a Tripartite Complex With the Anchoring Protein SAP97 and CaMKII in Cardiac Myocytes

Circulation research, 2009-03, Vol.104 (6), p.758-769

2009

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Cholesterol modulates the recruitment of Kv1.5 channels from Rab11-associated recycling endosome in native atrial myocytes

Proceedings of the National Academy of Sciences - PNAS, 2009-08, Vol.106 (34), p.14681-14686

2009

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SAP97 and Dystrophin Macromolecular Complexes Determine Two Pools of Cardiac Sodium Channels Nav1.5 in Cardiomyocytes

Circulation research, 2011-02, Vol.108 (3), p.294-304

2011

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The anchoring protein SAP97 retains Kv1.5 channels in the plasma membrane of cardiac myocytes

American journal of physiology. Heart and circulatory physiology, 2008-04, Vol.294 (4), p.H1851-H1861

2008

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The positive frequency-dependent electrophysiological effects of the IKur inhibitor XEN-D0103 are desirable for the treatment of atrial fibrillation

Heart rhythm, 2016-02, Vol.13 (2), p.555-564

2016

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Effect of selective I K,ACh inhibition by XAF-1407 in an equine model of tachypacing-induced persistent atrial fibrillation

British journal of pharmacology, 2020-08, Vol.177 (16), p.3778-3794

2020

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Response to Letters Regarding Article, “Rheumatic Heart Disease Screening by Echocardiography: The Inadequacy of World Health Organization Criteria for Optimizing the Diagnosis of Subclinical Disease”

Circulation (New York, N.Y.), 2010-06, Vol.121 (21)

2010

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Enhancing Maturation and Translatability of Human Pluripotent Stem Cell-Derived Cardiomyocytes through a Novel Medium Containing Acetyl-CoA Carboxylase 2 Inhibitor

Cells (Basel, Switzerland), 2024-08, Vol.13 (16), p.1339

2024

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Development of an impedance based screening assay for cardiac safety and cardiotoxicity detection

Journal of pharmacological and toxicological methods, 2020-09, Vol.105, p.106849, Article 106849

2020

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A benzopyran with antiarrhythmic activity is an inhibitor of Kir3.1-containing potassium channels

The Journal of biological chemistry, 2021-01, Vol.296, p.100535-100535, Article 100535

2021

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Assessment of human induced pluripotent stem-cell derived cardiomyocytes for evaluating drug induced arrhythmias with multi-electrode array

Journal of pharmacological and toxicological methods, 2019-09, Vol.99, p.106595, Article 106595

2019

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Novel K+ Channel Targets in Atrial Fibrillation Drug Development—Where Are We?

Journal of cardiovascular pharmacology, 2015-11, Vol.66 (5), p.412-431

2015

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Electrophysiological characterisation of cellular dynamics international ventricular iCell2 iPSC-derived cardiomyocytes

Journal of pharmacological and toxicological methods, 2018-09, Vol.93, p.168-168

2018

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Comprehensive profiling of axiogenesis ventricular vCor.4U iPSC-derived cardiomyocytes—From electrophysiology to phenotypic assays

Journal of pharmacological and toxicological methods, 2018-09, Vol.93, p.167-168

2018

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CiPA Update: Refining In Vitro Cardiac Ion Channel Assays, In Silico Models and iPSC-Derived Cardiomyocyte Reagents for Improved Pro-arrhythmia Risk Prediction

Journal of pharmacological and toxicological methods, 2017-11, Vol.88, p.199-199

2017

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Human Stem Cell-Derived Cardiomyocytes: In Vitro Assays and Screening Platforms for Exploring Ventricular and Atrial Phenotypes

Journal of pharmacological and toxicological methods, 2017-11, Vol.88, p.243-243

2017

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Differentiation and validation of human iPSC-derived atrial cardiomyocytes

Journal of pharmacological and toxicological methods, 2018-09, Vol.93, p.168-168

2018

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Human Ventricular Stem Cell Cardiomyocytes: Validating In Vitro Assays and Screening Platforms for Pro-arrhythmia Risk Prediction

Journal of pharmacological and toxicological methods, 2017-11, Vol.88, p.241-241

2017

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Abstract 18323: Positive Frequency-Dependent Effects of Highly Selective Kv1.5 Blockers (XEN-D0103 & MK-0448) in Right Atrial Trabeculae From Patients in Sinus Rhythm

Circulation (New York, N.Y.), 2013-11, Vol.128 (suppl_22)

2013

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Abstract 18632: The Potent, Selective Cardiac Acetylcholine-Activated Potassium Current Inhibitor XEN-R0706 Prolongs Human Atrial Action Potential Duration

Circulation (New York, N.Y.), 2013-11, Vol.128 (suppl_22)

2013

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Activation of Glibenclamide-Sensitive ATP-Sensitive K+ Channels During β-Adrenergically Induced Metabolic Stress Produces a Substrate for Atrial Tachyarrhythmia

Circulation. Arrhythmia and electrophysiology, 2012-12, Vol.5 (6), p.1184-1192

2012

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SAP97 and Dystrophin Macromolecular Complexes Determine Two Pools of Cardiac Sodium Channels Na v 1.5 in Cardiomyocytes

Circulation research, 2011-02, Vol.108 (3), p.294-304

2011

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Atrial‐like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial‐selective pharmacology

Effect of selective IK,ACh inhibition by XAF‐1407 in an equine model of tachypacing‐induced persistent atrial fibrillation

Rheumatic Heart Disease Screening by Echocardiography The Inadequacy of World Health Organization Criteria for Optimizing the Diagnosis of Subclinical Disease

Kv4 Potassium Channels Form a Tripartite Complex With the Anchoring Protein SAP97 and CaMKII in Cardiac Myocytes

Cholesterol modulates the recruitment of Kv1.5 channels from Rab11-associated recycling endosome in native atrial myocytes

SAP97 and Dystrophin Macromolecular Complexes Determine Two Pools of Cardiac Sodium Channels Nav1.5 in Cardiomyocytes

The anchoring protein SAP97 retains Kv1.5 channels in the plasma membrane of cardiac myocytes

The positive frequency-dependent electrophysiological effects of the IKur inhibitor XEN-D0103 are desirable for the treatment of atrial fibrillation

Effect of selective I K,ACh inhibition by XAF-1407 in an equine model of tachypacing-induced persistent atrial fibrillation

Response to Letters Regarding Article, “Rheumatic Heart Disease Screening by Echocardiography: The Inadequacy of World Health Organization Criteria for Optimizing the Diagnosis of Subclinical Disease”

Enhancing Maturation and Translatability of Human Pluripotent Stem Cell-Derived Cardiomyocytes through a Novel Medium Containing Acetyl-CoA Carboxylase 2 Inhibitor

Development of an impedance based screening assay for cardiac safety and cardiotoxicity detection

A benzopyran with antiarrhythmic activity is an inhibitor of Kir3.1-containing potassium channels

Assessment of human induced pluripotent stem-cell derived cardiomyocytes for evaluating drug induced arrhythmias with multi-electrode array

Novel K+ Channel Targets in Atrial Fibrillation Drug Development—Where Are We?

Electrophysiological characterisation of cellular dynamics international ventricular iCell2 iPSC-derived cardiomyocytes

Comprehensive profiling of axiogenesis ventricular vCor.4U iPSC-derived cardiomyocytes—From electrophysiology to phenotypic assays

CiPA Update: Refining In Vitro Cardiac Ion Channel Assays, In Silico Models and iPSC-Derived Cardiomyocyte Reagents for Improved Pro-arrhythmia Risk Prediction

Human Stem Cell-Derived Cardiomyocytes: In Vitro Assays and Screening Platforms for Exploring Ventricular and Atrial Phenotypes

Differentiation and validation of human iPSC-derived atrial cardiomyocytes

Human Ventricular Stem Cell Cardiomyocytes: Validating In Vitro Assays and Screening Platforms for Pro-arrhythmia Risk Prediction

Abstract 18323: Positive Frequency-Dependent Effects of Highly Selective Kv1.5 Blockers (XEN-D0103 & MK-0448) in Right Atrial Trabeculae From Patients in Sinus Rhythm

Abstract 18632: The Potent, Selective Cardiac Acetylcholine-Activated Potassium Current Inhibitor XEN-R0706 Prolongs Human Atrial Action Potential Duration

Activation of Glibenclamide-Sensitive ATP-Sensitive K+ Channels During β-Adrenergically Induced Metabolic Stress Produces a Substrate for Atrial Tachyarrhythmia

SAP97 and Dystrophin Macromolecular Complexes Determine Two Pools of Cardiac Sodium Channels Na v 1.5 in Cardiomyocytes

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