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Cardiac late Na+ current: Proarrhythmic effects, roles in long QT syndromes, and pathological relationship to CaMKII and oxidative stress

Heart rhythm, 2015-02, Vol.12 (2), p.440-448

2015

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A Missense Variant in PLEC Increases Risk of Atrial Fibrillation

Journal of the American College of Cardiology, 2017-10, Vol.70 (17), p.2157-2168

2017

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Phytosterol accumulation results in ventricular arrhythmia, impaired cardiac function and death in mice

Scientific reports, 2021-08, Vol.11 (1), p.17449-17449, Article 17449

2021

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Mutations in SCN10A Are Responsible for a Large Fraction of Cases of Brugada Syndrome

Journal of the American College of Cardiology, 2014-07, Vol.64 (1), p.66-79

2014

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Meta-Analysis of Mechano-Sensitive Ion Channels in Human Hearts: Chamber- and Disease-Preferential mRNA Expression

International journal of molecular sciences, 2023-06, Vol.24 (13), p.10961

2023

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Pro-arrhythmic effects of low plasma [K+] in human ventricle: An illustrated review

Trends in cardiovascular medicine, 2018-05, Vol.28 (4), p.233-242

2018

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Small Conductance Ca2 +-Activated K+ (SK) Channel mRNA Expression in Human Atrial and Ventricular Tissue: Comparison Between Donor, Atrial Fibrillation and Heart Failure Tissue

Frontiers in physiology, 2021-04, Vol.12, p.650964-650964

2021

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Selective late sodium current inhibitor GS‐458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia

British journal of pharmacology, 2018-06, Vol.175 (12), p.2470-2482

2018

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Sequence variants with large effects on cardiac electrophysiology and disease

Nature communications, 2019-10, Vol.10 (1), p.4803-10, Article 4803

2019

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Unmasking atrial repolarization to assess alternans, spatiotemporal heterogeneity, and susceptibility to atrial fibrillation

Heart rhythm, 2016-04, Vol.13 (4), p.953-961

2016

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A computational model predicts adjunctive pharmacotherapy for cardiac safety via selective inhibition of the late cardiac Na current

Journal of molecular and cellular cardiology, 2016-10, Vol.99, p.151-161

2016

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Inhibition of the cardiac late sodium current with eleclazine protects against ischemia-induced vulnerability to atrial fibrillation and reduces atrial and ventricular repolarization abnormalities in the absence and presence of concurrent adrenergic stimulation

Heart rhythm, 2016-09, Vol.13 (9), p.1860-1867

2016

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Eleclazine, a new selective cardiac late sodium current inhibitor, confers concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in an intact porcine model

Heart rhythm, 2016-08, Vol.13 (8), p.1679-1686

2016

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Eleclazine, an inhibitor of the cardiac late sodium current, is superior to flecainide in suppressing catecholamine-induced ventricular tachycardia and T-wave alternans in an intact porcine model

Heart rhythm, 2017-03, Vol.14 (3), p.448-454

2017

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If inhibition in the atrioventricular node by ivabradine causes rate-dependent slowing of conduction and reduces ventricular rate during atrial fibrillation

Heart rhythm, 2014-12, Vol.11 (12), p.2288-2296

2014

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Simulation and mechanistic investigation of the arrhythmogenic role of the late sodium current in human heart failure

PloS one, 2012-03, Vol.7 (3), p.e32659-e32659

2012

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Use-dependent block of cardiac late Na+ current by ranolazine

Heart rhythm, 2009-11, Vol.6 (11), p.1625-1631

2009

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Selective late INa inhibition by GS-458967 exerts parallel suppression of catecholamine-induced hemodynamically significant ventricular tachycardia and T-wave alternans in an intact porcine model

Heart rhythm, 2015-12, Vol.12 (12), p.2508-2514

2015

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Effect of ranolazine on ventricular repolarization in class III antiarrhythmic drug-treated rabbits

Heart rhythm, 2012-12, Vol.9 (12), p.2051-2058

2012

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Pharmacological rescue of human K+ channel long-QT2 mutations: Human ether-a-go-go-related gene rescue without block

Circulation (New York, N.Y.), 2002-06, Vol.105 (24), p.2830-2835

2002

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Overexpression of SCN5A in mouse heart mimics human syndrome of enhanced atrioventricular nodal conduction

Heart rhythm, 2015-05, Vol.12 (5), p.1036-1045

2015

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New Insights into the Beneficial Electrophysiologic Profile of Ranolazine in Heart Failure: Prevention of Ventricular Fibrillation With Increased Postrepolarization Refractoriness and Without Drug-Induced Proarrhythmia

Journal of cardiac failure, 2012-12, Vol.18 (12), p.939-949

2012

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Block of Tetrodotoxin-sensitive, Nav1.7, and Tetrodotoxin-resistant, Nav1.8, Na+ channels by Ranolazine

Channels (Austin, Tex.), 2008-11, Vol.2 (6), p.449-460

2008

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Protein trafficking abnormalities: a new mechanism in drug‐induced long QT syndrome

British journal of pharmacology, 2005-05, Vol.145 (1), p.3-4

2005

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Cardiac late Na+ current: Proarrhythmic effects, roles in long QT syndromes, and pathological relationship to CaMKII and oxidative stress

A Missense Variant in PLEC Increases Risk of Atrial Fibrillation

Phytosterol accumulation results in ventricular arrhythmia, impaired cardiac function and death in mice

Mutations in SCN10A Are Responsible for a Large Fraction of Cases of Brugada Syndrome

Meta-Analysis of Mechano-Sensitive Ion Channels in Human Hearts: Chamber- and Disease-Preferential mRNA Expression

Pro-arrhythmic effects of low plasma [K+] in human ventricle: An illustrated review

Small Conductance Ca2 +-Activated K+ (SK) Channel mRNA Expression in Human Atrial and Ventricular Tissue: Comparison Between Donor, Atrial Fibrillation and Heart Failure Tissue

Selective late sodium current inhibitor GS‐458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia

Sequence variants with large effects on cardiac electrophysiology and disease

Unmasking atrial repolarization to assess alternans, spatiotemporal heterogeneity, and susceptibility to atrial fibrillation

A computational model predicts adjunctive pharmacotherapy for cardiac safety via selective inhibition of the late cardiac Na current

Inhibition of the cardiac late sodium current with eleclazine protects against ischemia-induced vulnerability to atrial fibrillation and reduces atrial and ventricular repolarization abnormalities in the absence and presence of concurrent adrenergic stimulation

Eleclazine, a new selective cardiac late sodium current inhibitor, confers concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in an intact porcine model

Eleclazine, an inhibitor of the cardiac late sodium current, is superior to flecainide in suppressing catecholamine-induced ventricular tachycardia and T-wave alternans in an intact porcine model

If inhibition in the atrioventricular node by ivabradine causes rate-dependent slowing of conduction and reduces ventricular rate during atrial fibrillation

Simulation and mechanistic investigation of the arrhythmogenic role of the late sodium current in human heart failure

Use-dependent block of cardiac late Na+ current by ranolazine

Selective late INa inhibition by GS-458967 exerts parallel suppression of catecholamine-induced hemodynamically significant ventricular tachycardia and T-wave alternans in an intact porcine model

Effect of ranolazine on ventricular repolarization in class III antiarrhythmic drug-treated rabbits

Pharmacological rescue of human K+ channel long-QT2 mutations: Human ether-a-go-go-related gene rescue without block

Overexpression of SCN5A in mouse heart mimics human syndrome of enhanced atrioventricular nodal conduction

Coding variants in RPL3L and MYZAP increase risk of atrial fibrillation

New Insights into the Beneficial Electrophysiologic Profile of Ranolazine in Heart Failure: Prevention of Ventricular Fibrillation With Increased Postrepolarization Refractoriness and Without Drug-Induced Proarrhythmia

Block of Tetrodotoxin-sensitive, Nav1.7, and Tetrodotoxin-resistant, Nav1.8, Na+ channels by Ranolazine

Protein trafficking abnormalities: a new mechanism in drug‐induced long QT syndrome

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