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Chronic Cardiotoxicity Assays Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs)

International journal of molecular sciences, 2022-03, Vol.23 (6), p.3199

2022

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International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment

Cell reports (Cambridge), 2018-09, Vol.24 (13), p.3582-3592

2018

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Comprehensive Translational Assessment of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias

Toxicological sciences, 2017-01, Vol.155 (1), p.234-247

2017

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Comprehensive In Vitro Proarrhythmia Assay (CiPA) Update from a Cardiac Safety Research Consortium / Health and Environmental Sciences Institute / FDA Meeting

Therapeutic innovation & regulatory science, 2019-07, Vol.53 (4), p.519-525

2019

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Human in vitro assay for irreversible electroporation cardiac ablation

Frontiers in physiology, 2023-01, Vol.13, p.1064168-1064168

2023

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Differences in PGE2 production between primary human monocytes and differentiated macrophages: role of IL-1β and TRIF/IRF3

PloS one, 2014-05, Vol.9 (5), p.e98517-e98517

2014

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Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block

PloS one, 2020-11, Vol.15 (11), p.e0241362-e0241362

2020

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Acute effects of cardiac contractility modulation on human induced pluripotent stem cell–derived cardiomyocytes

Physiological reports, 2021-11, Vol.9 (21), p.e15085-n/a

2021

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Clinical Trial in a Dish: Personalized Stem Cell–Derived Cardiomyocyte Assay Compared With Clinical Trial Results for Two QT‐Prolonging Drugs

Clinical and translational science, 2019-11, Vol.12 (6), p.687-697

2019

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Human cardiomyocytes are more susceptible to irreversible electroporation by pulsed electric field than human esophageal cells

Physiological reports, 2022-10, Vol.10 (20), p.e15493-n/a

2022

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Acute effects of cardiac contractility modulation stimulation in conventional 2D and 3D human induced pluripotent stem cell-derived cardiomyocyte models

Frontiers in physiology, 2022-11, Vol.13, p.1023563-1023563

2022

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Use of human MonoMac6 cells for development of in vitro assay predictive of adjuvant safety in vivo

Vaccine, 2012-07, Vol.30 (32), p.4859-4865

2012

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Human in vitro neurocardiac coculture (ivNCC) assay development for evaluating cardiac contractility modulation

Physiological reports, 2022-11, Vol.10 (21), p.n/a

2022

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Distribution of Mitochondrial NADH Fluorescence Lifetimes: Steady-State Kinetics of Matrix NADH Interactions

Biochemistry (Easton), 2005-02, Vol.44 (7), p.2585-2594

2005

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CRISPR/Cas9‐mediated introduction of the sodium/iodide symporter gene enables noninvasive in vivo tracking of induced pluripotent stem cell‐derived cardiomyocytes

Stem cells translational medicine, 2020-10, Vol.9 (10), p.1203-1217

2020

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Comprehensive Collection of Current Methods for Contractility and Electrophysiology Recordings in Human Cardiac Cells

Journal of visualized experiments, 2023-03 (193)

2023

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Clinical Trials in a Dish

Trends in pharmacological sciences (Regular ed.), 2017-01, Vol.38 (1), p.4-7

2017

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Abstract 256: Human In Vitro Model for Preclinical Evaluation of Irreversible Electroporation Devices Used for Cardiac Ablation

Circulation research, 2020-07, Vol.127 (Suppl_1)

2020

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B-PO03-019 CARDIAC CONTRACTILITY MODULATION STIMULATION DURING SYSTOLE ENHANCES CONTRACTION AND CALCIUM HANDLING PROPERTIES IN HUMAN-INDUCED PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES

Heart rhythm, 2021-08, Vol.18 (8), p.S196-S196

2021

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B-AB06-04 HUMAN IN VITRO MODEL FOR PRECLINICAL EVALUATION OF PULSED ELECTRIC FIELD-BASED DEVICES FOR NON-THERMAL CARDIAC ABLATION

Heart rhythm, 2021-08, Vol.18 (8), p.S11-S11

2021

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Abstract 13129: Human in vitro Study on Pulsed Electric Field Cardiac Ablation Cell Sensitivity

Circulation (New York, N.Y.), 2022-11, Vol.146 (Suppl_1)

2022

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Abstract P1123: Establishment Of An In Vitro Method To Evaluate Chronic Cardiac Contractility Modulation Signals In 3d Human Engineered Cardiac Tissues

Circulation research, 2022-08, Vol.131 (Suppl_1)

2022

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Assessment of Proarrhythmic Potential of Drugs in Optogenetically Paced Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Toxicological sciences, 2019-07, Vol.170 (1), p.167-179

2019

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Abstract 11951: Acute Cardiac Contractility Modulation Assessment in Conventional 2D Monolayers and 3D Engineered Cardiac Tissues Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Circulation (New York, N.Y.), 2022-11, Vol.146 (Suppl_1)

2022

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Nonclinical evaluation of chronic cardiac contractility modulation on 3D human engineered cardiac tissues

Journal of cardiovascular electrophysiology, 2024-05, Vol.35 (5), p.895-905

2024

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Chronic Cardiotoxicity Assays Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs)

International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment

Comprehensive Translational Assessment of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias

Comprehensive In Vitro Proarrhythmia Assay (CiPA) Update from a Cardiac Safety Research Consortium / Health and Environmental Sciences Institute / FDA Meeting

Human in vitro assay for irreversible electroporation cardiac ablation

Differences in PGE2 production between primary human monocytes and differentiated macrophages: role of IL-1β and TRIF/IRF3

Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block

Acute effects of cardiac contractility modulation on human induced pluripotent stem cell–derived cardiomyocytes

Clinical Trial in a Dish: Personalized Stem Cell–Derived Cardiomyocyte Assay Compared With Clinical Trial Results for Two QT‐Prolonging Drugs

Human cardiomyocytes are more susceptible to irreversible electroporation by pulsed electric field than human esophageal cells

Acute effects of cardiac contractility modulation stimulation in conventional 2D and 3D human induced pluripotent stem cell-derived cardiomyocyte models

Use of human MonoMac6 cells for development of in vitro assay predictive of adjuvant safety in vivo

Human in vitro neurocardiac coculture (ivNCC) assay development for evaluating cardiac contractility modulation

Distribution of Mitochondrial NADH Fluorescence Lifetimes: Steady-State Kinetics of Matrix NADH Interactions

CRISPR/Cas9‐mediated introduction of the sodium/iodide symporter gene enables noninvasive in vivo tracking of induced pluripotent stem cell‐derived cardiomyocytes

Comprehensive Collection of Current Methods for Contractility and Electrophysiology Recordings in Human Cardiac Cells

Clinical Trials in a Dish

Abstract 256: Human In Vitro Model for Preclinical Evaluation of Irreversible Electroporation Devices Used for Cardiac Ablation

B-PO03-019 CARDIAC CONTRACTILITY MODULATION STIMULATION DURING SYSTOLE ENHANCES CONTRACTION AND CALCIUM HANDLING PROPERTIES IN HUMAN-INDUCED PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES

B-AB06-04 HUMAN IN VITRO MODEL FOR PRECLINICAL EVALUATION OF PULSED ELECTRIC FIELD-BASED DEVICES FOR NON-THERMAL CARDIAC ABLATION

Abstract 13129: Human in vitro Study on Pulsed Electric Field Cardiac Ablation Cell Sensitivity

Abstract P1123: Establishment Of An In Vitro Method To Evaluate Chronic Cardiac Contractility Modulation Signals In 3d Human Engineered Cardiac Tissues

Assessment of Proarrhythmic Potential of Drugs in Optogenetically Paced Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Abstract 11951: Acute Cardiac Contractility Modulation Assessment in Conventional 2D Monolayers and 3D Engineered Cardiac Tissues Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Nonclinical evaluation of chronic cardiac contractility modulation on 3D human engineered cardiac tissues

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