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Design, Synthesis, and Biological Evaluation of MEK PROTACs

Journal of medicinal chemistry, 2020-01, Vol.63 (1), p.157-162

2020

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Author Correction: PI3K inhibitors are finally coming of age

Nature reviews. Drug discovery, 2021-10, Vol.20 (10), p.798-798

2021

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The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating

PloS one, 2012-02, Vol.7 (2), p.e31640-e31640

2012

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Getting to the heart of hERG K+ channel gating

The Journal of physiology, 2015-06, Vol.593 (12), p.2575-2585

2015

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Structural and conformational determinants of macrocycle cell permeability

Nature chemical biology, 2016-12, Vol.12 (12), p.1065-1074

2016

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TECRL: connecting sequence to consequence for a new sudden cardiac death gene

EMBO molecular medicine, 2016-12, Vol.8 (12), p.1364-1365

2016

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The N-terminal tail of hERG contains an amphipathic α-helix that regulates channel deactivation

PloS one, 2011-01, Vol.6 (1), p.e16191

2011

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Stabilization of protein-protein interactions in drug discovery

Expert opinion on drug discovery, 2017-09, Vol.12 (9), p.925-940

2017

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A class of highly selective inhibitors bind to an active state of PI3Kγ

Nature chemical biology, 2019-04, Vol.15 (4), p.348-357

2019

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Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3‑Kinase (PI3K)‑γ Inhibitors

Journal of medicinal chemistry, 2018-06, Vol.61 (12), p.5435-5441

2018

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Recent advances in understanding and prevention of sudden cardiac death [version 1; peer review: 2 approved]

F1000 research, 2017, Vol.6, p.1614-1614

2017

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Co-expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic events

Cardiovascular research, 2021-08, Vol.117 (10), p.2216-2227

2021

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Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein–Protein Interaction

ACS chemical biology, 2020-04, Vol.15 (4), p.1026-1035

2020

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Protocol-Dependent Differences in IC50 Values Measured in Human Ether-Á-Go-Go-Related Gene Assays Occur in a Predictable Way and Can Be Used to Quantify State Preference of Drug Binding

Molecular pharmacology, 2019-05, Vol.95 (5), p.537-550

2019

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Pathophysiological metabolic changes associated with disease modify the proarrhythmic risk profile of drugs with potential to prolong repolarisation

British journal of pharmacology, 2022-06, Vol.179 (11), p.2631-2646

2022

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Using many different voltage protocols to characterise discrepancy in mathematical ion channel models

Biophysical journal, 2023-02, Vol.122 (3), p.242a-242a

2023

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High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants

Heart rhythm, 2020-03, Vol.17 (3), p.492-500

2020

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Spiro-fused Pyrrolidine, Piperidine, and Oxindole Scaffolds from Lactams

Organic letters, 2012-09, Vol.14 (18), p.4846-4849

2012

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14-3-3 modulation of the inflammatory response

Pharmacological research, 2021-01, Vol.163, p.105236-105236, Article 105236

2021

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Action Potential Morphology Accurately Predicts Proarrhythmic Risk for Drugs With Potential to Prolong Cardiac Repolarization

Circulation. Arrhythmia and electrophysiology, 2023-07, Vol.16 (7), p.399-410

2023

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Protocol-Dependent Differences in IC 50 Values Measured in Human Ether-Á-Go-Go-Related Gene Assays Occur in a Predictable Way and Can Be Used to Quantify State Preference of Drug Binding

Molecular pharmacology, 2019-05, Vol.95 (5), p.537-550

2019

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Convergence of models of human ventricular myocyte electrophysiology after global optimization to recapitulate clinical long QT phenotypes

Journal of molecular and cellular cardiology, 2016-11, Vol.100, p.25-34

2016

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Designing novel building blocks is an overlooked strategy to improve compound quality

Drug discovery today, 2015-01, Vol.20 (1), p.11-17

2015

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Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2

Nature communications, 2014-09, Vol.5 (1), p.5069-5069, Article 5069

2014

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Surprising lipophilicity observations identify unexpected conformational effects

Bioorganic & medicinal chemistry letters, 2022-08, Vol.69, p.128786, Article 128786

2022

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Design, Synthesis, and Biological Evaluation of MEK PROTACs

Author Correction: PI3K inhibitors are finally coming of age

The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating

Getting to the heart of hERG K+ channel gating

Structural and conformational determinants of macrocycle cell permeability

TECRL: connecting sequence to consequence for a new sudden cardiac death gene

The N-terminal tail of hERG contains an amphipathic α-helix that regulates channel deactivation

Stabilization of protein-protein interactions in drug discovery

A class of highly selective inhibitors bind to an active state of PI3Kγ

Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3‑Kinase (PI3K)‑γ Inhibitors

Recent advances in understanding and prevention of sudden cardiac death [version 1; peer review: 2 approved]

Co-expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic events

Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein–Protein Interaction

Protocol-Dependent Differences in IC50 Values Measured in Human Ether-Á-Go-Go-Related Gene Assays Occur in a Predictable Way and Can Be Used to Quantify State Preference of Drug Binding

Pathophysiological metabolic changes associated with disease modify the proarrhythmic risk profile of drugs with potential to prolong repolarisation

Using many different voltage protocols to characterise discrepancy in mathematical ion channel models

High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants

Spiro-fused Pyrrolidine, Piperidine, and Oxindole Scaffolds from Lactams

14-3-3 modulation of the inflammatory response

Action Potential Morphology Accurately Predicts Proarrhythmic Risk for Drugs With Potential to Prolong Cardiac Repolarization

Protocol-Dependent Differences in IC 50 Values Measured in Human Ether-Á-Go-Go-Related Gene Assays Occur in a Predictable Way and Can Be Used to Quantify State Preference of Drug Binding

Convergence of models of human ventricular myocyte electrophysiology after global optimization to recapitulate clinical long QT phenotypes

Designing novel building blocks is an overlooked strategy to improve compound quality

Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2

Surprising lipophilicity observations identify unexpected conformational effects

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