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Small-Molecule Stabilization of Protein-Protein Interactions: An Underestimated Concept in Drug Discovery?

Angewandte Chemie (International ed.), 2012-02, Vol.51 (9), p.2012-2018

International ed. in English, 2012

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Modulators of Protein–Protein Interactions

Chemical reviews, 2014-05, Vol.114 (9), p.4695-4748

2014

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14-3-3: A Case Study in PPI Modulation

Molecules (Basel, Switzerland), 2018-06, Vol.23 (6), p.1386

2018

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Modulators of 14-3‑3 Protein–Protein Interactions

Journal of medicinal chemistry, 2018-05, Vol.61 (9), p.3755-3778

2018

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Ultra-large chemical libraries for the discovery of high-affinity peptide binders

Nature communications, 2020-06, Vol.11 (1), p.3183-11, Article 3183

2020

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Intermolecular channels direct crystal orientation in mineralized collagen

Nature communications, 2020-10, Vol.11 (1), p.5068-5068, Article 5068

2020

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A Binary Bivalent Supramolecular Assembly Platform Based on Cucurbit[8]uril and Dimeric Adapter Protein 14‐3‐3

Angewandte Chemie (International ed.), 2017-07, Vol.56 (31), p.8998-9002

International ed. in English, 2017

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The Molecular Tweezer CLR01 Stabilizes a Disordered Protein–Protein Interface

Journal of the American Chemical Society, 2017-11, Vol.139 (45), p.16256-16263

2017

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Stabilization of Protein–Protein Interactions in chemical biology and drug discovery

Progress in biophysics and molecular biology, 2015-10, Vol.119 (1), p.10-19

2015

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Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions

Nature communications, 2020-08, Vol.11 (1), p.1-9, Article 3954

2020

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Stabilization of Protein–Protein Interactions between CaMKK2 and 14–3–3 by Fusicoccins

ACS chemical biology, 2020-11, Vol.15 (11), p.3060-3071

2020

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TEAD–YAP Interaction Inhibitors and MDM2 Binders from DNA‐Encoded Indole‐Focused Ugi Peptidomimetics

Angewandte Chemie (International ed.), 2020-11, Vol.59 (46), p.20338-20342

International ed. in English, 2020

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Structural view of a fungal toxin acting on a 14-3-3 regulatory complex

The EMBO journal, 2003-03, Vol.22 (5), p.987-994

2003

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A simple method for developing lysine targeted covalent protein reagents

Nature communications, 2023-12, Vol.14 (1), p.7933-7933, Article 7933

2023

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Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR

Nature communications, 2022-06, Vol.13 (1), p.3586-3586, Article 3586

2022

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Stabilization and Inhibition of Protein–Protein Interactions: The 14-3‑3 Case Study

ACS chemical biology, 2013-01, Vol.8 (1), p.27-35

2013

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Stabilization of protein-protein interactions in drug discovery

Expert opinion on drug discovery, 2017-09, Vol.12 (9), p.925-940

2017

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Activation of NF-κB signalling by fusicoccin-induced dimerization

Proceedings of the National Academy of Sciences - PNAS, 2013-01, Vol.110 (5), p.E377-E386

2013

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Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR

Proceedings of the National Academy of Sciences - PNAS, 2016-03, Vol.113 (9), p.E1152-E1161

2016

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Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras Signaling

Molecular and Cellular Biology, 2010-10, Vol.30 (19), p.4698-4711

2010

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Structure of the p53 C-terminus bound to 14-3-3: Implications for stabilization of the p53 tetramer

FEBS letters, 2010-04, Vol.584 (8), p.1443-1448

2010

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Small‐molecule stabilization of the p53 – 14‐3‐3 protein‐protein interaction

FEBS letters, 2017-08, Vol.591 (16), p.2449-2457

2017

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Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface

ChemMedChem, 2016-04, Vol.11 (8), p.911-918

2016

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The chemistry and biology of syringolins, glidobactins and cepafungins (syrbactins)

Natural product reports, 2011-01, Vol.28 (11), p.1854-1867

2011

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Cooperativity basis for small-molecule stabilization of protein-protein interactions

Chemical science (Cambridge), 2019, Vol.10 (10), p.2869-2874

2019

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Small-Molecule Stabilization of Protein-Protein Interactions: An Underestimated Concept in Drug Discovery?

Modulators of Protein–Protein Interactions

14-3-3: A Case Study in PPI Modulation

Modulators of 14-3‑3 Protein–Protein Interactions

Ultra-large chemical libraries for the discovery of high-affinity peptide binders

Intermolecular channels direct crystal orientation in mineralized collagen

A Binary Bivalent Supramolecular Assembly Platform Based on Cucurbit[8]uril and Dimeric Adapter Protein 14‐3‐3

The Molecular Tweezer CLR01 Stabilizes a Disordered Protein–Protein Interface

Stabilization of Protein–Protein Interactions in chemical biology and drug discovery

Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions

Stabilization of Protein–Protein Interactions between CaMKK2 and 14–3–3 by Fusicoccins

TEAD–YAP Interaction Inhibitors and MDM2 Binders from DNA‐Encoded Indole‐Focused Ugi Peptidomimetics

Structural view of a fungal toxin acting on a 14-3-3 regulatory complex

A simple method for developing lysine targeted covalent protein reagents

Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR

Stabilization and Inhibition of Protein–Protein Interactions: The 14-3‑3 Case Study

Stabilization of protein-protein interactions in drug discovery

Activation of NF-κB signalling by fusicoccin-induced dimerization

Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR

Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras Signaling

Structure of the p53 C-terminus bound to 14-3-3: Implications for stabilization of the p53 tetramer

Small‐molecule stabilization of the p53 – 14‐3‐3 protein‐protein interaction

Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface

The chemistry and biology of syringolins, glidobactins and cepafungins (syrbactins)

Cooperativity basis for small-molecule stabilization of protein-protein interactions

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