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hERG K(+) channels: structure, function, and clinical significance

Physiological reviews, 2012-07, Vol.92 (3), p.1393-1478

2012

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Towards a Structural View of Drug Binding to hERG K+ Channels

Trends in pharmacological sciences (Regular ed.), 2017-10, Vol.38 (10), p.899-907

2017

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Assessing drug safety by identifying the axis of arrhythmia in cardiomyocyte electrophysiology

eLife, 2023-12, Vol.12

2023

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Molecular Docking Guided Grid-Independent Descriptor Analysis to Probe the Impact of Water Molecules on Conformational Changes of hERG Inhibitors in Drug Trapping Phenomenon

International journal of molecular sciences, 2019-07, Vol.20 (14), p.3385

2019

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A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm

Journal of biomolecular screening, 2016-01, Vol.21 (1), p.1-11

2016

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Development of automated patch clamp assays to overcome the burden of variants of uncertain significance in inheritable arrhythmia syndromes

Frontiers in physiology, 2023-11, Vol.14, p.1294741-1294741

2023

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Arrhythmogenic effects of ultra-long and bistable cardiac action potentials

PLoS computational biology, 2021-02, Vol.17 (2), p.e1008683-e1008683

2021

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Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics

The Journal of physiology, 2017-04, Vol.595 (7), p.2229-2252

2017

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Potassium channels in the heart: structure, function and regulation

The Journal of physiology, 2017-04, Vol.595 (7), p.2209-2228

2017

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High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11.1

Heart rhythm, 2020-12, Vol.17 (12), p.2180-2189

2020

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Structural basis of promiscuous substrate transport by Organic Cation Transporter 1

Nature communications, 2023-10, Vol.14 (1), p.6374-6374, Article 6374

2023

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Development of a robust induced pluripotent stem cell atrial cardiomyocyte differentiation protocol to model atrial arrhythmia

Stem cell research & therapy, 2023-07, Vol.14 (1), p.183-183

2023

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Domain Reorientation and Rotation of an Intracellular Assembly Regulate Conduction in Kir Potassium Channels

Cell, 2010-06, Vol.141 (6), p.1018-1029

2010

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R222Q SCN5A Mutation Is Associated With Reversible Ventricular Ectopy and Dilated Cardiomyopathy

Journal of the American College of Cardiology, 2012-10, Vol.60 (16), p.1566-1573

2012

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Multiple Interactions between Cytoplasmic Domains Regulate Slow Deactivation of Kv11.1 Channels

The Journal of biological chemistry, 2014-09, Vol.289 (37), p.25822-25832

2014

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The diagnostic role of T wave morphology biomarkers in congenital and acquired long QT syndrome: A systematic review

Annals of noninvasive electrocardiology, 2023-01, Vol.28 (1), p.e13015-n/a

2023

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Experimentally Validated Pharmacoinformatics Approach to Predict hERG Inhibition Potential of New Chemical Entities

Frontiers in pharmacology, 2018-09, Vol.9, p.1035-1035

2018

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Drug Binding to the Inactivated State Is Necessary but Not Sufficient for High-Affinity Binding to Human Ether-Ã -go-go-Related Gene Channels

Molecular pharmacology, 2008-11, Vol.74 (5), p.1443-1452

2008

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The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating

PloS one, 2012-02, Vol.7 (2), p.e31640-e31640

2012

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A transgenic zebrafish model of a human cardiac sodium channel mutation exhibits bradycardia, conduction-system abnormalities and early death

Journal of molecular and cellular cardiology, 2013-08, Vol.61, p.123-132

2013

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The N-terminal tail of hERG contains an amphipathic α-helix that regulates channel deactivation

PloS one, 2011-01, Vol.6 (1), p.e16191

2011

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The schizophrenia-associated Kv11.1-3.1 isoform results in reduced current accumulation during repetitive brief depolarizations

PloS one, 2012-09, Vol.7 (9), p.e45624-e45624

2012

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TECRL: connecting sequence to consequence for a new sudden cardiac death gene

EMBO molecular medicine, 2016-12, Vol.8 (12), p.1364-1365

2016

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Getting to the heart of hERG K+ channel gating

The Journal of physiology, 2015-06, Vol.593 (12), p.2575-2585

2015

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The S1 helix critically regulates the finely tuned gating of Kv11.1 channels

The Journal of biological chemistry, 2017-05, Vol.292 (18), p.7688-7705

2017

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hERG K(+) channels: structure, function, and clinical significance

Towards a Structural View of Drug Binding to hERG K+ Channels

Assessing drug safety by identifying the axis of arrhythmia in cardiomyocyte electrophysiology

Molecular Docking Guided Grid-Independent Descriptor Analysis to Probe the Impact of Water Molecules on Conformational Changes of hERG Inhibitors in Drug Trapping Phenomenon

A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm

Development of automated patch clamp assays to overcome the burden of variants of uncertain significance in inheritable arrhythmia syndromes

Arrhythmogenic effects of ultra-long and bistable cardiac action potentials

Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics

Potassium channels in the heart: structure, function and regulation

High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11.1

Structural basis of promiscuous substrate transport by Organic Cation Transporter 1

Development of a robust induced pluripotent stem cell atrial cardiomyocyte differentiation protocol to model atrial arrhythmia

Domain Reorientation and Rotation of an Intracellular Assembly Regulate Conduction in Kir Potassium Channels

R222Q SCN5A Mutation Is Associated With Reversible Ventricular Ectopy and Dilated Cardiomyopathy

Multiple Interactions between Cytoplasmic Domains Regulate Slow Deactivation of Kv11.1 Channels

The diagnostic role of T wave morphology biomarkers in congenital and acquired long QT syndrome: A systematic review

Experimentally Validated Pharmacoinformatics Approach to Predict hERG Inhibition Potential of New Chemical Entities

Drug Binding to the Inactivated State Is Necessary but Not Sufficient for High-Affinity Binding to Human Ether-Ã -go-go-Related Gene Channels

The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating

A transgenic zebrafish model of a human cardiac sodium channel mutation exhibits bradycardia, conduction-system abnormalities and early death

The N-terminal tail of hERG contains an amphipathic α-helix that regulates channel deactivation

The schizophrenia-associated Kv11.1-3.1 isoform results in reduced current accumulation during repetitive brief depolarizations

TECRL: connecting sequence to consequence for a new sudden cardiac death gene

Getting to the heart of hERG K+ channel gating

The S1 helix critically regulates the finely tuned gating of Kv11.1 channels

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