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Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension

Nature communications, 2016-01, Vol.7 (1), p.10366-10366, Article 10366

2016

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High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11.1

Heart rhythm, 2020-12, Vol.17 (12), p.2180-2189

2020

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Getting to the heart of hERG K+ channel gating

The Journal of physiology, 2015-06, Vol.593 (12), p.2575-2585

2015

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Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations

Communications biology, 2021-09, Vol.4 (1), p.1038-1038, Article 1038

2021

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Clinical interpretation of KCNH2 variants using a robust PS3/BS3 functional patch-clamp assay

HGG advances, 2024-04, Vol.5 (2), p.100270-100270, Article 100270

2024

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When it takes two to get one into trouble

Heart rhythm, 2022-02, Vol.19 (2), p.293-294

2022

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A massively parallel assay accurately discriminates between functionally normal and abnormal variants in a hotspot domain of KCNH2

American journal of human genetics, 2022-07, Vol.109 (7), p.1208-1216

2022

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High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants

Heart rhythm, 2020-03, Vol.17 (3), p.492-500

2020

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Development of automated patch clamp assays to overcome the burden of variants of uncertain significance in inheritable arrhythmia syndromes

Frontiers in physiology, 2023-11, Vol.14, p.1294741-1294741

2023

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A calibrated functional patch-clamp assay to enhance clinical variant interpretation in KCNH2-related long QT syndrome

American journal of human genetics, 2022-07, Vol.109 (7), p.1199-1207

2022

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Effects of cohort, genotype, variant, and maternal β-blocker treatment on foetal heart rate predictors of inherited long QT syndrome

Europace (London, England), 2023-11, Vol.25 (11)

2023

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Multiple Interactions between Cytoplasmic Domains Regulate Slow Deactivation of Kv11.1 Channels

The Journal of biological chemistry, 2014-09, Vol.289 (37), p.25822-25832

2014

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Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2

Nature communications, 2014-09, Vol.5 (1), p.5069-5069, Article 5069

2014

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The N-terminal tail of hERG contains an amphipathic α-helix that regulates channel deactivation

PloS one, 2011-01, Vol.6 (1), p.e16191

2011

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The S1 helix critically regulates the finely tuned gating of Kv11.1 channels

The Journal of biological chemistry, 2017-05, Vol.292 (18), p.7688-7705

2017

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Tyrosine Residues from the S4-S5 Linker of Kv11.1 Channels Are Critical for Slow Deactivation

The Journal of biological chemistry, 2016-08, Vol.291 (33), p.17293-17302

2016

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Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels

The Journal of general physiology, 2012-09, Vol.140 (3), p.293-306

2012

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The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating

PloS one, 2012-02, Vol.7 (2), p.e31640-e31640

2012

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Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-throughput automated patch clamp electrophysiology

Biology methods and protocols, 2021, Vol.6 (1), p.bpab003-bpab003

2021

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C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels

PloS one, 2013-10, Vol.8 (10), p.e77032-e77032

2013

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Pharmacological activation of IKr in models of long QT Type 2 risks overcorrection of repolarization

Cardiovascular research, 2020-07, Vol.116 (8), p.1434-1445

2020

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Modified N-Linked Glycosylation Status Predicts Trafficking Defective Piezo1 Channel Mutations

Biophysical journal, 2021-02, Vol.120 (3), p.236a-237a

2021

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Pore Helices Play a Dynamic Role as Integrators of Domain Motion during Kv11.1 Channel Inactivation Gating

The Journal of biological chemistry, 2013-04, Vol.288 (16), p.11482-11491

2013

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Rescue of protein expression defects may not be enough to abolish the pro‐arrhythmic phenotype of long QT type 2 mutations

The Journal of physiology, 2016-07, Vol.594 (14), p.4031-4049

2016

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Mechanically-Induced Gating in PKD2L1 (Trpp2): Calcium-Induced Activation Masquerading as Force Sensitivity?

Biophysical journal, 2017-02, Vol.112 (3), p.311a-311a

2017

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Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension

High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11.1

Getting to the heart of hERG K+ channel gating

Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations

Clinical interpretation of KCNH2 variants using a robust PS3/BS3 functional patch-clamp assay

When it takes two to get one into trouble

A massively parallel assay accurately discriminates between functionally normal and abnormal variants in a hotspot domain of KCNH2

High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants

Development of automated patch clamp assays to overcome the burden of variants of uncertain significance in inheritable arrhythmia syndromes

A calibrated functional patch-clamp assay to enhance clinical variant interpretation in KCNH2-related long QT syndrome

Effects of cohort, genotype, variant, and maternal β-blocker treatment on foetal heart rate predictors of inherited long QT syndrome

Multiple Interactions between Cytoplasmic Domains Regulate Slow Deactivation of Kv11.1 Channels

Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2

The N-terminal tail of hERG contains an amphipathic α-helix that regulates channel deactivation

The S1 helix critically regulates the finely tuned gating of Kv11.1 channels

Tyrosine Residues from the S4-S5 Linker of Kv11.1 Channels Are Critical for Slow Deactivation

Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels

The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating

Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-throughput automated patch clamp electrophysiology

C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels

Pharmacological activation of IKr in models of long QT Type 2 risks overcorrection of repolarization

Modified N-Linked Glycosylation Status Predicts Trafficking Defective Piezo1 Channel Mutations

Pore Helices Play a Dynamic Role as Integrators of Domain Motion during Kv11.1 Channel Inactivation Gating

Rescue of protein expression defects may not be enough to abolish the pro‐arrhythmic phenotype of long QT type 2 mutations

Mechanically-Induced Gating in PKD2L1 (Trpp2): Calcium-Induced Activation Masquerading as Force Sensitivity?

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