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Development and Application of a Transcriptomic Signature of Bioactivation in an Advanced In Vitro Liver Model to Reduce Drug-induced Liver Injury Risk Early in the Pharmaceutical Pipeline

Toxicological sciences, 2020-09, Vol.177 (1), p.121-139

2020

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Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy

ACS medicinal chemistry letters, 2019-11, Vol.10 (11), p.1530-1536

2019

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Matrix-assisted laser desorption/ionization imaging mass spectrometry for direct measurement of clozapine in rat brain tissue

Rapid communications in mass spectrometry, 2006-03, Vol.20 (6), p.965-972

2006

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Strategic Incorporation of Polarity in Heme-Displacing Inhibitors of Indoleamine-2,3-dioxygenase‑1 (IDO1)

ACS medicinal chemistry letters, 2020-04, Vol.11 (4), p.550-557

2020

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Qualification and application of an in vitro liver model early in pharmaceutical development to help derisk drug-induced liver injury (DILI)

Drug metabolism and pharmacokinetics, 2019-01, Vol.34 (1), p.S42-S42

2019

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A Two-Tiered In Vitro Approach to De-Risk Drug Candidates for Potential Bile Salt Export Pump Inhibition Liabilities in Drug Discovery

Drug metabolism and disposition, 2020-11, Vol.48 (11), p.1147-1160

2020

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In vivo bioluminescence imaging of labile iron in xenograft models and liver using FeAL-1, an iron-activatable form of D-luciferin

Cell chemical biology, 2023-11, Vol.30 (11), p.1468-1477.e6

2023

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Vicriviroc (SCH 417690) Distribution from the Gut to Gut-Associated Lymphoid Tissues (GALT) and to Peripheral Lymphoid Tissues Following an Oral Dose

Retrovirology, 2005-12, Vol.2 (S1), p.P115-P115, Article P115

2005

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Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes

Bioorganic & medicinal chemistry letters, 2020-09, Vol.30 (17), p.127390-127390, Article 127390

2020

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Utilization of Metabolite Identification and Structural Data to Guide Design of Low-Dose IDO1 Inhibitors

ACS medicinal chemistry letters, 2021-09, Vol.12 (9), p.1435-1440

2021

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Abstract 4721: Combining STING agonists with an anti-PD-1 antagonist results in marked antitumor activity in immune-excluded tumors

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.4721-4721

2018

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Carbamate and N‑Pyrimidine Mitigate Amide Hydrolysis: Structure-Based Drug Design of Tetrahydroquinoline IDO1 Inhibitors

ACS medicinal chemistry letters, 2021-03, Vol.12 (3), p.389-396

2021

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Diminishing GSH-Adduct Formation of Tricyclic Diazepine-based Mutant IDH1 Inhibitors

ACS medicinal chemistry letters, 2022-04, Vol.13 (4), p.734-741

2022

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Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension

ACS medicinal chemistry letters, 2017-01, Vol.8 (1), p.128-132

2017

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Abstract A08: Combination with a novel STING agonist significantly improves efficacy of anti-PD1 therapy in mouse syngeneic tumor models

Cancer immunology research, 2018-09, Vol.6 (9_Supplement), p.A08-A08

2018

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Intestinal lymphatic transport for drug delivery: The Lymphatic System: Therapy, Imaging and Nanotechnology

Advanced drug delivery reviews, 2011, Vol.63 (10-11), p.923-942

2011

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Cremophor reduces paclitaxel penetration into bladder wall during intravesical treatment

Cancer chemotherapy and pharmacology, 1999, Vol.44 (3), p.241-248

1999

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Visualization of first-pass drug metabolism of terfenadine by MALDI-imaging mass spectrometry

Drug metabolism letters, 2008-01, Vol.2 (1), p.1

2008

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Development and Application of a Transcriptomic Signature of Bioactivation in an Advanced In Vitro Liver Model to Reduce Drug-induced Liver Injury Risk Early in the Pharmaceutical Pipeline

Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy

Matrix-assisted laser desorption/ionization imaging mass spectrometry for direct measurement of clozapine in rat brain tissue

Strategic Incorporation of Polarity in Heme-Displacing Inhibitors of Indoleamine-2,3-dioxygenase‑1 (IDO1)

Qualification and application of an in vitro liver model early in pharmaceutical development to help derisk drug-induced liver injury (DILI)

A Two-Tiered In Vitro Approach to De-Risk Drug Candidates for Potential Bile Salt Export Pump Inhibition Liabilities in Drug Discovery

In vivo bioluminescence imaging of labile iron in xenograft models and liver using FeAL-1, an iron-activatable form of D-luciferin

Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing

Vicriviroc (SCH 417690) Distribution from the Gut to Gut-Associated Lymphoid Tissues (GALT) and to Peripheral Lymphoid Tissues Following an Oral Dose

Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes

Utilization of Metabolite Identification and Structural Data to Guide Design of Low-Dose IDO1 Inhibitors

Abstract 4721: Combining STING agonists with an anti-PD-1 antagonist results in marked antitumor activity in immune-excluded tumors

Carbamate and N‑Pyrimidine Mitigate Amide Hydrolysis: Structure-Based Drug Design of Tetrahydroquinoline IDO1 Inhibitors

Diminishing GSH-Adduct Formation of Tricyclic Diazepine-based Mutant IDH1 Inhibitors

Discovery of 8‑Amino-imidazo[1,5‑a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis

Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension

Abstract A08: Combination with a novel STING agonist significantly improves efficacy of anti-PD1 therapy in mouse syngeneic tumor models

siRNA-Mediated Knockdown of P450 Oxidoreductase in Rats: A Tool to Reduce Metabolism by CYPs and Increase Exposure of High Clearance Compounds

Intestinal lymphatic transport for drug delivery: The Lymphatic System: Therapy, Imaging and Nanotechnology

Cremophor reduces paclitaxel penetration into bladder wall during intravesical treatment

Visualization of first-pass drug metabolism of terfenadine by MALDI-imaging mass spectrometry

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