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Design, Synthesis, and Evaluation of Novel and Selective G‑protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists

ACS medicinal chemistry letters, 2017-01, Vol.8 (1), p.49-54

2017

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Discovery of a nortropanol derivative as a potent and orally active GPR119 agonist for type 2 diabetes

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (11), p.3290-3296

2011

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Benzimidazole-substituted (3-phenoxypropyl)amines as histamine H3 receptor ligands

Bioorganic & medicinal chemistry, 2008-09, Vol.18 (18), p.5032-5036

2008

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Tetrahydroquinoline sulfonamides as vasopressin 1b receptor anatgonists

Bioorganic & medicinal chemistry letters, 2009-11, Vol.19 (21), p.6018-6022

2009

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2,6-Disubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2007, Vol.17 (1), p.57-62

2007

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Hydrogen-Bonding Motifs and Proton-Transfer Dynamics in Electronically Excited 6‑Hydroxy-2-formylfulvene

The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory, 2019-08, Vol.123 (30), p.6506-6526

2019

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Synthesis and Evaluation of Polycyclic Pyrazolo[3,4-d]pyrimidines as PDE1 and PDE5 cGMP Phosphodiesterase Inhibitors

Journal of medicinal chemistry, 1997-12, Vol.40 (26), p.4372-4377

1997

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Phyllanthoside-phyllanthostatin synthetic studies. 8. Total synthesis of (+)-phyllanthoside. Development of the Mitsunobu glycosyl ester protocol

Journal of the American Chemical Society, , Vol.113 (6), p.2092-2112

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I. Novel HCV NS5B polymerase inhibitors: Discovery of indole 2-carboxylic acids with C3-heterocycles

Bioorganic & medicinal chemistry letters, 2011-09, Vol.21 (18), p.5336-5341

2011

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Iminopyrimidinones: A novel pharmacophore for the development of orally active renin inhibitors

Bioorganic & medicinal chemistry letters, 2015-04, Vol.25 (7), p.1592-1596

2015

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Phyllanthoside-phyllanthostatin synthetic studies. 7. Total synthesis of (+)-phyllanthocin and (+)-phyllanthocindiol

Journal of the American Chemical Society, , Vol.113 (6), p.2071-2092

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Discovery of a series of potent arylthiadiazole H 3 antagonists

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (2), p.861-864

2011

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Total synthesis of (.+-.)-breynolide, an aglycon derivative of the orally active hypocholesterolemic agent breynin A

Journal of the American Chemical Society, 1992-11, Vol.114 (24), p.9419-9434

1992

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The discovery of novel tartrate-based TNF-α converting enzyme (TACE) inhibitors

Bioorganic & medicinal chemistry letters, 2010-02, Vol.20 (3), p.1189-1193

2010

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Discovery of a series of potent arylthiadiazole H sub(3) antagonists

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (2), p.861-864

2011

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Discovery of a series of potent arylthiadiazole H₃ antagonists

Bioorganic & medicinal chemistry letters, 2011, Vol.21 (2), p.861-864

2011

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Structure and activity relationships of tartrate-based TACE inhibitors

Bioorganic & medicinal chemistry letters, 2010-08, Vol.20 (16), p.4812-4815

2010

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Phyllanthoside-phyllanthostatin synthetic studies. 9. Total syntheses of (-)-phyllanthostatin 1, (+)-phyllanthostatin 2, and (+)-phyllanthostatin 3

Journal of the American Chemical Society, 1991-03, Vol.113 (6), p.2112-2122

1991

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Total synthesis of (.+-.)-breynolide: an aglycon derivative of a potent, orally active hypocholesterolemic agent

Journal of the American Chemical Society, 1991-05, Vol.113 (10), p.4037-4038

1991

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The discovery of novel tartrate-based TNF-a converting enzyme (TACE) inhibitors

Bioorganic & medicinal chemistry letters, 2010-09, Vol.20 (3), p.1189-1193

2010

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Solution-Phase Parallel Synthesis of Carbamates as γ-Secretase Inhibitors

Journal of Combinatorial Chemistry, 2008-01, Vol.10 (1), p.56-62

2008

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Discovery of a series of potent arylthiadiazole H(3) antagonists

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (2), p.861-864

2011

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Tetrahydroquinoline sulfonamides as vasopressin 1b receptor antagonists

Bioorganic & medicinal chemistry letters, 2009-11, Vol.19 (21), p.6018-6022

2009

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Design, Synthesis, and Evaluation of Novel and Selective G‑protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists

Discovery of a nortropanol derivative as a potent and orally active GPR119 agonist for type 2 diabetes

Benzimidazole-substituted (3-phenoxypropyl)amines as histamine H3 receptor ligands

Tetrahydroquinoline sulfonamides as vasopressin 1b receptor anatgonists

2,6-Disubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors

Hydrogen-Bonding Motifs and Proton-Transfer Dynamics in Electronically Excited 6‑Hydroxy-2-formylfulvene

Synthesis and Evaluation of Polycyclic Pyrazolo[3,4-d]pyrimidines as PDE1 and PDE5 cGMP Phosphodiesterase Inhibitors

Phyllanthoside-phyllanthostatin synthetic studies. 8. Total synthesis of (+)-phyllanthoside. Development of the Mitsunobu glycosyl ester protocol

Discovery of 8‑Amino-imidazo[1,5‑a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis

I. Novel HCV NS5B polymerase inhibitors: Discovery of indole 2-carboxylic acids with C3-heterocycles

Iminopyrimidinones: A novel pharmacophore for the development of orally active renin inhibitors

Phyllanthoside-phyllanthostatin synthetic studies. 7. Total synthesis of (+)-phyllanthocin and (+)-phyllanthocindiol

Discovery of a series of potent arylthiadiazole H 3 antagonists

Total synthesis of (.+-.)-breynolide, an aglycon derivative of the orally active hypocholesterolemic agent breynin A

The discovery of novel tartrate-based TNF-α converting enzyme (TACE) inhibitors

Discovery of a series of potent arylthiadiazole H sub(3) antagonists

Discovery of a series of potent arylthiadiazole H₃ antagonists

Structure and activity relationships of tartrate-based TACE inhibitors

Phyllanthoside-phyllanthostatin synthetic studies. 9. Total syntheses of (-)-phyllanthostatin 1, (+)-phyllanthostatin 2, and (+)-phyllanthostatin 3

Total synthesis of (.+-.)-breynolide: an aglycon derivative of a potent, orally active hypocholesterolemic agent

The discovery of novel tartrate-based TNF-a converting enzyme (TACE) inhibitors

Solution-Phase Parallel Synthesis of Carbamates as γ-Secretase Inhibitors

Discovery of a series of potent arylthiadiazole H(3) antagonists

Potent Tetracyclic Guanine Inhibitors of PDE1 and PDE5 Cyclic Guanosine Monophosphate Phosphodiesterases with Oral Antihypertensive Activity

Tetrahydroquinoline sulfonamides as vasopressin 1b receptor antagonists

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