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Histone Deacetylase Inhibitors

Journal of medicinal chemistry, 2003-11, Vol.46 (24), p.5097-5116

2003

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Evaluation of JAK3 Biology in Autoimmune Disease Using a Highly Selective, Irreversible JAK3 Inhibitor

The Journal of pharmacology and experimental therapeutics, 2017-05, Vol.361 (2), p.229

2017

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Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2)

Bioorganic & medicinal chemistry, 2008-01, Vol.18 (2), p.726-731

2008

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Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2)

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (3), p.973-978

2008

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A Divergent Approach to the Synthesis of 3-Substituted-2-pyrazolines: Suzuki Cross-Coupling of 3-Sulfonyloxy-2-pyrazolines

Journal of organic chemistry, 2009-08, Vol.74 (16), p.6390-6393

2009

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Lovastatin Nonaketide Synthase Catalyzes an Intramolecular Diels−Alder Reaction of a Substrate Analogue

Journal of the American Chemical Society, 2000-11, Vol.122 (46), p.11519-11520

2000

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A New Strategy for the Synthesis of Benzylic Sulfonamides: Palladium-Catalyzed Arylation and Sulfonamide Metathesis

Journal of organic chemistry, 2007-10, Vol.72 (21), p.8135-8138

2007

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Aminosuberoyl hydroxamic acids (ASHAs): A potent new class of HDAC inhibitors

Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (14), p.3969-3971

2007

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Benzo[b]thiophene-based histone deacetylase inhibitors

Bioorganic & medicinal chemistry letters, 2007-08, Vol.17 (16), p.4562-4567

2007

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Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor

ACS medicinal chemistry letters, 2014-04, Vol.5 (4), p.340-345

2014

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Health status of individuals with mild stroke

Stroke (1970), 1997-04, Vol.28 (4), p.740-745

1997

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Design of novel histone deacetylase inhibitors

Bioorganic & medicinal chemistry letters, 2007-08, Vol.17 (16), p.4619-4624

2007

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Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2)

Bioorganic & medicinal chemistry letters, 2009-04, Vol.19 (7), p.2053-2058

2009

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Phenylglycine and phenylalanine derivatives as potent and selective HDAC1 inhibitors (SHI-1)

Bioorganic & medicinal chemistry, 2008-03, Vol.18 (6), p.1859-1863

2008

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Development of a Flexible and Robust Synthesis of Tetrahydrofuro[3,4‑b]furan Nucleoside Analogues

Journal of organic chemistry, 2021-04, Vol.86 (7), p.5142-5151

2021

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Uzbek Militancy in Pakistan's Tribal Region

Witter, David

2011

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Putative Diels−Alder-Catalyzed Cyclization during the Biosynthesis of Lovastatin

Journal of organic chemistry, 1996-04, Vol.61 (8), p.2613-2623

1996

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Phase (Ph) 1/2a study of CLN-081 in patients (pts) with NSCLC with EGFR exon 20 insertion mutations (Ins20)

Journal of clinical oncology, 2022-06, Vol.40 (16_suppl), p.9007-9007

2022

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Phenylglycine and phenylalanine derivatives as potent and selective HDAC1 inhibitors (SHI-1)

Bioorganic & medicinal chemistry letters, , Vol.18 (6), p.1859-1863

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Safety and activity of CLN-081 (TAS6417) in NSCLC with EGFR Exon 20 insertion mutations (Ins20)

Journal of clinical oncology, 2021-05, Vol.39 (15_suppl), p.9077-9077

2021

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Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitors

Bioorganic & medicinal chemistry letters, 2020-01, Vol.30 (1), p.126715, Article 126715

2020

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Structure-dependent Impairment of Intracellular Apolipoprotein E4 Trafficking and Its Detrimental Effects Are Rescued by Small-molecule Structure Correctors

The Journal of biological chemistry, 2011-05, Vol.286 (19), p.17217-17226

2011

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Quality of anticoagulation management among patients with atrial fibrillation: results of a review of medical records from 2 communities

Archives of internal medicine (1960), 2000-04, Vol.160 (7), p.967

2000

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Histone Deacetylase Inhibitors

Evaluation of JAK3 Biology in Autoimmune Disease Using a Highly Selective, Irreversible JAK3 Inhibitor

Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2)

Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2)

A Divergent Approach to the Synthesis of 3-Substituted-2-pyrazolines: Suzuki Cross-Coupling of 3-Sulfonyloxy-2-pyrazolines

Lovastatin Nonaketide Synthase Catalyzes an Intramolecular Diels−Alder Reaction of a Substrate Analogue

A New Strategy for the Synthesis of Benzylic Sulfonamides: Palladium-Catalyzed Arylation and Sulfonamide Metathesis

Aminosuberoyl hydroxamic acids (ASHAs): A potent new class of HDAC inhibitors

Benzo[b]thiophene-based histone deacetylase inhibitors

Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor

Health status of individuals with mild stroke

Design of novel histone deacetylase inhibitors

Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2)

Phenylglycine and phenylalanine derivatives as potent and selective HDAC1 inhibitors (SHI-1)

Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors

Development of a Flexible and Robust Synthesis of Tetrahydrofuro[3,4‑b]furan Nucleoside Analogues

Uzbek Militancy in Pakistan's Tribal Region

Putative Diels−Alder-Catalyzed Cyclization during the Biosynthesis of Lovastatin

Phase (Ph) 1/2a study of CLN-081 in patients (pts) with NSCLC with EGFR exon 20 insertion mutations (Ins20)

Phenylglycine and phenylalanine derivatives as potent and selective HDAC1 inhibitors (SHI-1)

The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer

Safety and activity of CLN-081 (TAS6417) in NSCLC with EGFR Exon 20 insertion mutations (Ins20)

Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitors

Structure-dependent Impairment of Intracellular Apolipoprotein E4 Trafficking and Its Detrimental Effects Are Rescued by Small-molecule Structure Correctors

Quality of anticoagulation management among patients with atrial fibrillation: results of a review of medical records from 2 communities

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