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Modulators of 14-3‑3 Protein–Protein Interactions

Journal of medicinal chemistry, 2018-05, Vol.61 (9), p.3755-3778

2018

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Expansion of chemical space for collaborative lead generation and drug discovery: the European Lead Factory Perspective

Drug discovery today, 2015-11, Vol.20 (11), p.1310-1316

2015

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Aspergillosis due to Voriconazole Highly Resistant Aspergillus fumigatus and Recovery of Genetically Related Resistant Isolates From Domiciles

Clinical infectious diseases, 2013-08, Vol.57 (4), p.513-520

2013

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Stabilization of protein-protein interactions in drug discovery

Expert opinion on drug discovery, 2017-09, Vol.12 (9), p.925-940

2017

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Azole Resistance Profile of Amino Acid Changes in Aspergillus fumigatus CYP51A Based on Protein Homology Modeling

Antimicrobial Agents and Chemotherapy, 2010-06, Vol.54 (6), p.2425-2430

2010

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Genotype–phenotype complexity of the TR46/Y121F/T289A cyp51A azole resistance mechanism in Aspergillus fumigatus

Fungal genetics and biology, 2015-09, Vol.82, p.129-135

2015

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A Versatile Strategy for the Synthesis of 4,5-Dihydroxy-2,3-Pentanedione (DPD) and Related Compounds as Potential Modulators of Bacterial Quorum Sensing

Molecules (Basel, Switzerland), 2018-10, Vol.23 (10), p.2545

2018

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The structure–function relationship of the Aspergillus fumigatus cyp51A L98H conversion by site-directed mutagenesis: The mechanism of L98H azole resistance

Fungal genetics and biology, 2011-11, Vol.48 (11), p.1062-1070

2011

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Refining the structure−activity relationships of 2-phenylcyclopropane carboxylic acids as inhibitors of O-acetylserine sulfhydrylase isoforms

Journal of enzyme inhibition and medicinal chemistry, 2019-01, Vol.34 (1), p.31-43

2019

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Design and Synthesis of Fsp3‑Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

ACS combinatorial science, 2016-06, Vol.18 (6), p.330-336

2016

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Interrogating dense ligand chemical space with a forward-synthetic library

Proceedings of the National Academy of Sciences - PNAS, 2019-06, Vol.116 (23), p.11496-11501

2019

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DPD-Inspired Discovery of Novel LsrK Kinase Inhibitors: An Opportunity To Fight Antimicrobial Resistance

Journal of medicinal chemistry, 2019-03, Vol.62 (5), p.2720-2737

2019

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The non-gastric H,K-ATPase as a tool to study the ouabain-binding site in Na,K-ATPase

Pflügers Archiv, 2009-01, Vol.457 (3), p.623-634

2009

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Design and Synthesis of Fsp(3)-Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

ACS combinatorial science, 2016-06, Vol.18 (6), p.330

2016

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Design and synthesis of 4,5,6,7‐tetrahydro‐1H‐1,2‐diazepin‐7‐one derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors

Bioorganic & medicinal chemistry letters, 2017-01, Vol.27 (1), p.24-29

2017

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Design and synthesis of 1,1-disubstituted-1-silacycloalkane-based compound libraries

Bioorganic & medicinal chemistry, 2015-06, Vol.23 (11), p.2716-2720

2015

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Design and synthesis of 4,5,6,7‐tetrahydro‐1 H ‐1,2‐diazepin‐7‐one derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors

Bioorganic & medicinal chemistry letters, 2017-01, Vol.27 (1), p.24-29

2017

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Design and Synthesis of Fsp 3 -Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

ACS combinatorial science, 2016-06, Vol.18 (6), p.330-336

2016

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The European Lead Factory: A Blueprint for Public-Private Partnerships in Early Drug Discovery

Frontiers in medicine, 2017-01, Vol.3, p.75-75

2017

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Properties of flavonoids influencing the binding to bilitranslocase investigated by neural network modelling

Biochemical pharmacology, 2007-01, Vol.73 (2), p.308-320

2007

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Mechanism of Bleomycin Suicide: A Car−Parrinello Molecular Dynamics Investigation

The journal of physical chemistry. B, 2006-10, Vol.110 (42), p.21245-21250

2006

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The metal bonding domain of the antitumor drug Fe(II)-bleomycin: a DFT investigation

Journal of biological inorganic chemistry, 2005-01, Vol.10 (1), p.33-40

2005

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The metal bonding domain of the antitumor drug Fe(II)-bleomycin: a DFT investigation

Journal of biological inorganic chemistry, 2005-03, Vol.10 (2), p.208-208

2005

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The structure–function relationship of the Aspergillus fumigatuscyp51A L98H conversion by site-directed mutagenesis: The mechanism of L98H azole resistance

Fungal genetics and biology, 2011-11, Vol.48 (11), p.1062-1070

2011

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A rational design to create hybrid β-sheet breaker peptides to inhibit aggregation and toxicity of amyloid-β

MedChemComm, 2011-01, Vol.2 (1), p.60-64

2011

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Modulators of 14-3‑3 Protein–Protein Interactions

Expansion of chemical space for collaborative lead generation and drug discovery: the European Lead Factory Perspective

Aspergillosis due to Voriconazole Highly Resistant Aspergillus fumigatus and Recovery of Genetically Related Resistant Isolates From Domiciles

Stabilization of protein-protein interactions in drug discovery

Azole Resistance Profile of Amino Acid Changes in Aspergillus fumigatus CYP51A Based on Protein Homology Modeling

Genotype–phenotype complexity of the TR46/Y121F/T289A cyp51A azole resistance mechanism in Aspergillus fumigatus

A Versatile Strategy for the Synthesis of 4,5-Dihydroxy-2,3-Pentanedione (DPD) and Related Compounds as Potential Modulators of Bacterial Quorum Sensing

The structure–function relationship of the Aspergillus fumigatus cyp51A L98H conversion by site-directed mutagenesis: The mechanism of L98H azole resistance

Refining the structure−activity relationships of 2-phenylcyclopropane carboxylic acids as inhibitors of O-acetylserine sulfhydrylase isoforms

Design and Synthesis of Fsp3‑Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

Interrogating dense ligand chemical space with a forward-synthetic library

DPD-Inspired Discovery of Novel LsrK Kinase Inhibitors: An Opportunity To Fight Antimicrobial Resistance

The non-gastric H,K-ATPase as a tool to study the ouabain-binding site in Na,K-ATPase

Design and Synthesis of Fsp(3)-Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

Design and synthesis of 4,5,6,7‐tetrahydro‐1H‐1,2‐diazepin‐7‐one derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors

Design and synthesis of 1,1-disubstituted-1-silacycloalkane-based compound libraries

Design and synthesis of 4,5,6,7‐tetrahydro‐1 H ‐1,2‐diazepin‐7‐one derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors

Design and Synthesis of Fsp 3 -Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

The European Lead Factory: A Blueprint for Public-Private Partnerships in Early Drug Discovery

Properties of flavonoids influencing the binding to bilitranslocase investigated by neural network modelling

Mechanism of Bleomycin Suicide: A Car−Parrinello Molecular Dynamics Investigation

The metal bonding domain of the antitumor drug Fe(II)-bleomycin: a DFT investigation

The metal bonding domain of the antitumor drug Fe(II)-bleomycin: a DFT investigation

The structure–function relationship of the Aspergillus fumigatuscyp51A L98H conversion by site-directed mutagenesis: The mechanism of L98H azole resistance

A rational design to create hybrid β-sheet breaker peptides to inhibit aggregation and toxicity of amyloid-β

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