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Pyrazolyl-Ureas as Interesting Scaffold in Medicinal Chemistry

Molecules (Basel, Switzerland), 2020-07, Vol.25 (15), p.3457

2020

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New Series of Pyrazoles and Imidazo-Pyrazoles Targeting Different Cancer and Inflammation Pathways

Molecules (Basel, Switzerland), 2021-09, Vol.26 (19), p.5735

2021

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New Hybrid Pyrazole and Imidazopyrazole Antinflammatory Agents Able to Reduce ROS Production in Different Biological Targets

Molecules (Basel, Switzerland), 2020-02, Vol.25 (4), p.899

2020

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Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer's disease

Scientific reports, 2017-04, Vol.7 (1), p.46320, Article 46320

2017

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The Pyrazolyl-Urea Gege3 Inhibits the Activity of ANXA1 in the Angiogenesis Induced by the Pancreatic Cancer Derived EVs

Biomolecules (Basel, Switzerland), 2021-11, Vol.11 (12), p.1758

2021

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Insight into GEBR-32a: Chiral Resolution, Absolute Configuration and Enantiopreference in PDE4D Inhibition

Molecules (Basel, Switzerland), 2020-02, Vol.25 (4), p.935

2020

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Benzimidazole-based derivatives as privileged scaffold developed for the treatment of the RSV infection: a computational study exploring the potency and cytotoxicity profiles

Journal of enzyme inhibition and medicinal chemistry, 2017, Vol.32 (1), p.375-402

2017

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New Selective Phosphodiesterase 4D Inhibitors Differently Acting on Long, Short, and Supershort Isoforms

Journal of medicinal chemistry, 2009-11, Vol.52 (21), p.6546-6557

2009

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Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines

European journal of medicinal chemistry, 2008-12, Vol.43 (12), p.2665-2676

2008

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Pyrazole and imidazo[1,2-b]pyrazole Derivatives as New Potential Antituberculosis Agents

Medicinal chemistry (Shp-sariqah, United Arab Emirates), 2019, Vol.15 (1), p.17

2019

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Synthesis, antiplatelet and antithrombotic activities of new 2-substituted benzopyrano[4,3-d]pyrimidin-4-cycloamines and 4-amino/cycloamino-benzopyrano[4,3-d]pyrimidin-5-ones

Bioorganic & medicinal chemistry, 2006, Vol.14 (1), p.121-130

2006

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Identification of a Novel Pyrazolo[3,4-d]pyrimidine Able To Inhibit Cell Proliferation of a Human Osteogenic Sarcoma in Vitro and in a Xenograft Model in Mice

Journal of medicinal chemistry, 2007-11, Vol.50 (23), p.5579-5588

2007

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Pyrazolo[3,4-d]pyrimidines as Potent Antiproliferative and Proapoptotic Agents toward A431 and 8701-BC Cells in Culture via Inhibition of c-Src Phosphorylation

Journal of medicinal chemistry, 2006-03, Vol.49 (5), p.1549-1561

2006

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Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line

European journal of medicinal chemistry, 2004-11, Vol.39 (11), p.939-946

2004

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Synthesis and Biological Evaluation of N-Pyrazolyl-N‘-alkyl/benzyl/phenylureas: a New Class of Potent Inhibitors of Interleukin 8-Induced Neutrophil Chemotaxis

Journal of medicinal chemistry, 2007-07, Vol.50 (15), p.3618-3626

2007

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Synthesis, functional proteomics and biological evaluation of new 5-pyrazolyl ureas as potential anti-angiogenic compounds

European journal of medicinal chemistry, 2021-12, Vol.226, p.113872, Article 113872

2021

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Relative stereochemistry of a diterpene from Salvia cinnabarina

Molecules (Basel, Switzerland), 2007-10, Vol.12 (10), p.2279-2287

2007

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Parallel one-pot synthesis and structure–activity relationship study of symmetric formimidoester disulfides as a novel class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors

Bioorganic & medicinal chemistry, 2008-06, Vol.16 (12), p.6353-6363

2008

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3-Arylsulphonyl-5-arylamino-1,3,4-thiadiazol-2(3 H)ones as anti-inflammatory and analgesic agents

Bioorganic & medicinal chemistry, 2001-08, Vol.9 (8), p.2149-2153

2001

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Design, synthesis, biological evaluation and structural characterization of novel GEBR library PDE4D inhibitors

European journal of medicinal chemistry, 2021-11, Vol.223, p.113638-113638, Article 113638

2021

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Design, synthesis and biological evaluation of new pyrazolyl-ureas and imidazopyrazolecarboxamides able to interfere with MAPK and PI3K upstream signaling involved in the angiogenesis

European journal of medicinal chemistry, 2017-06, Vol.133, p.24-35

2017

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Correction: Biological evaluation of pyrazolyl-urea and dihydro-imidazo-pyrazolyl-urea derivatives as potential anti-angiogenetic agents in the treatment of neuroblastoma

Oncotarget, 2023-02, Vol.14 (1), p.129-130

2023

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Novel insights on the molecular mechanism of action of the anti-angiogenic pyrazolyl-urea GeGe-3 by functional proteomics

Bioorganic chemistry, 2021-10, Vol.115, p.105168, Article 105168

2021

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Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology

Cellular and molecular life sciences : CMLS, 2023-07, Vol.80 (7), p.178-178, Article 178

2023

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New insights into PDE4B inhibitor selectivity: CoMFA analyses and molecular docking studies

Molecular diversity, 2016-02, Vol.20 (1), p.77-92

2016

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Pyrazolyl-Ureas as Interesting Scaffold in Medicinal Chemistry

New Series of Pyrazoles and Imidazo-Pyrazoles Targeting Different Cancer and Inflammation Pathways

New Hybrid Pyrazole and Imidazopyrazole Antinflammatory Agents Able to Reduce ROS Production in Different Biological Targets

Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer's disease

The Pyrazolyl-Urea Gege3 Inhibits the Activity of ANXA1 in the Angiogenesis Induced by the Pancreatic Cancer Derived EVs

Insight into GEBR-32a: Chiral Resolution, Absolute Configuration and Enantiopreference in PDE4D Inhibition

Benzimidazole-based derivatives as privileged scaffold developed for the treatment of the RSV infection: a computational study exploring the potency and cytotoxicity profiles

New Selective Phosphodiesterase 4D Inhibitors Differently Acting on Long, Short, and Supershort Isoforms

Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines

Pyrazole and imidazo[1,2-b]pyrazole Derivatives as New Potential Antituberculosis Agents

Synthesis, antiplatelet and antithrombotic activities of new 2-substituted benzopyrano[4,3-d]pyrimidin-4-cycloamines and 4-amino/cycloamino-benzopyrano[4,3-d]pyrimidin-5-ones

Identification of a Novel Pyrazolo[3,4-d]pyrimidine Able To Inhibit Cell Proliferation of a Human Osteogenic Sarcoma in Vitro and in a Xenograft Model in Mice

Pyrazolo[3,4-d]pyrimidines as Potent Antiproliferative and Proapoptotic Agents toward A431 and 8701-BC Cells in Culture via Inhibition of c-Src Phosphorylation

Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line

Synthesis and Biological Evaluation of N-Pyrazolyl-N‘-alkyl/benzyl/phenylureas: a New Class of Potent Inhibitors of Interleukin 8-Induced Neutrophil Chemotaxis

Synthesis, functional proteomics and biological evaluation of new 5-pyrazolyl ureas as potential anti-angiogenic compounds

Relative stereochemistry of a diterpene from Salvia cinnabarina

Parallel one-pot synthesis and structure–activity relationship study of symmetric formimidoester disulfides as a novel class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors

3-Arylsulphonyl-5-arylamino-1,3,4-thiadiazol-2(3 H)ones as anti-inflammatory and analgesic agents

Design, synthesis, biological evaluation and structural characterization of novel GEBR library PDE4D inhibitors

Design, synthesis and biological evaluation of new pyrazolyl-ureas and imidazopyrazolecarboxamides able to interfere with MAPK and PI3K upstream signaling involved in the angiogenesis

Correction: Biological evaluation of pyrazolyl-urea and dihydro-imidazo-pyrazolyl-urea derivatives as potential anti-angiogenetic agents in the treatment of neuroblastoma

Novel insights on the molecular mechanism of action of the anti-angiogenic pyrazolyl-urea GeGe-3 by functional proteomics

Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology

New insights into PDE4B inhibitor selectivity: CoMFA analyses and molecular docking studies

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