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DYRK1A inhibition as potential treatment for Alzheimer's disease

Future medicinal chemistry, 2016-04, Vol.8 (6), p.681

2016

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Recent Advances in the Design, Synthesis, and Biological Evaluation of Selective DYRK1A Inhibitors: A New Avenue for a Disease Modifying Treatment of Alzheimer’s?

ACS chemical neuroscience, 2012-11, Vol.3 (11), p.857-872

2012

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A facile and rapid route for the synthesis of novel 1,5-substituted tetrazole hydantoins and thiohydantoins via a TMSN3-Ugi/RNCX cyclization

Tetrahedron letters, 2012-10, Vol.53 (42), p.5593-5596

2012

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A Versatile Strategy for the Synthesis of 4,5-Dihydroxy-2,3-Pentanedione (DPD) and Related Compounds as Potential Modulators of Bacterial Quorum Sensing

Molecules (Basel, Switzerland), 2018-10, Vol.23 (10), p.2545

2018

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Novel Cambinol Analogs as Sirtuin Inhibitors: Synthesis, Biological Evaluation, and Rationalization of Activity

Journal of medicinal chemistry, 2009-05, Vol.52 (9), p.2673-2682

2009

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Design and Synthesis of Fsp3‑Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

ACS combinatorial science, 2016-06, Vol.18 (6), p.330-336

2016

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Exploiting the divalent nature of isonitriles: a novel Pictet–Spengler amidination process

Tetrahedron letters, 2014-05, Vol.55 (22), p.3328-3331

2014

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A facile and concise route toward the synthesis of novel imidazo-tetrazolodiazepinones via post-condensation modifications of the Ugi-azide adduct

Tetrahedron letters, 2015-09, Vol.56 (38), p.5295-5298

2015

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3-(4-Bromo-phen-yl)-1-butyl-5-[1-(2-chloro-6-methyl-phen-yl)-1H-tetra-zol-5-yl]imidazolidine-2,4-dione

Acta crystallographica. Section E, Structure reports online, 2013-07, Vol.69 (Pt 7), p.o1102-o1103

2013

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Synthesis of Diverse Nitrogen-Enriched Heterocyclic Scaffolds Using a Suite of Tunable One-Pot Multicomponent Reactions

Journal of organic chemistry, 2014-06, Vol.79 (11), p.5153-5162

2014

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From one to two quaternary centers: Ester or nitrile α-alkylation applied to bioactive alkaloids

Tetrahedron, 2018-12, Vol.74 (52), p.7399-7407

2018

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Facile and rapid route for the synthesis of novel norstatine analogs via PADAM-cyclization methodology

Tetrahedron letters, 2012-03, Vol.53 (11), p.1313-1315

2012

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Branching cascades provide access to two amino-oxazoline compound libraries

Bioorganic & medicinal chemistry, 2015-06, Vol.23 (11), p.2656-2665

2015

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Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound

Journal of controlled release, 2019-02, Vol.296, p.81-92

2019

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Design and Synthesis of Fsp(3)-Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

ACS combinatorial science, 2016-06, Vol.18 (6), p.330

2016

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Inhibitors to Overcome Secondary Mutations in the Stem Cell Factor Receptor KIT

Journal of medicinal chemistry, 2017-11, Vol.60 (21), p.8801-8815

2017

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Abstract 2661: Novel albumin-binding maytansinoids inducing long-term partial and complete tumor regressions in several human cancer xenograft models in nude mice

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.2661-2661

2018

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Abstract 3703: Superior efficacy of novel albumin-binding auristatin E-based prodrugs compared to auristatin E in a panel of human xenograft models in mice

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.3703-3703

2018

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Abstract 1657: Structure-activity relationship studies and biological evaluation of novel maytansinoids, a class of highly selective tubulin inhibitors

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.1657-1657

2018

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Facile and rapid route for the synthesis of novel conformationally constrained norstatine analogs via PADAM-cyclization methodology

Tetrahedron letters, 2012-03, Vol.53 (11), p.1313-1315

2012

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Design and Synthesis of Fsp 3 -Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

ACS combinatorial science, 2016-06, Vol.18 (6), p.330-336

2016

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Total synthesis of dehaloperophoramidine using a highly diastereoselective Hosomi-Sakurai reaction

Chemical communications (Cambridge, England), 2016-01, Vol.52 (71), p.10747-10750

2016

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Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PGE2 production in cells

Bioorganic & medicinal chemistry letters, 2013-01, Vol.23 (2), p.528-531

2013

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Gonadotropin-releasing hormone receptor levels and cell context affect tumor cell responses to agonist in vitro and in vivo

Cancer research (Chicago, Ill.), 2008-08, Vol.68 (15), p.6331-6340

2008

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DYRK1A inhibition as potential treatment for Alzheimer's disease

Recent Advances in the Design, Synthesis, and Biological Evaluation of Selective DYRK1A Inhibitors: A New Avenue for a Disease Modifying Treatment of Alzheimer’s?

A facile and rapid route for the synthesis of novel 1,5-substituted tetrazole hydantoins and thiohydantoins via a TMSN3-Ugi/RNCX cyclization

A Versatile Strategy for the Synthesis of 4,5-Dihydroxy-2,3-Pentanedione (DPD) and Related Compounds as Potential Modulators of Bacterial Quorum Sensing

Novel Cambinol Analogs as Sirtuin Inhibitors: Synthesis, Biological Evaluation, and Rationalization of Activity

Design and Synthesis of Fsp3‑Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

Exploiting the divalent nature of isonitriles: a novel Pictet–Spengler amidination process

A facile and concise route toward the synthesis of novel imidazo-tetrazolodiazepinones via post-condensation modifications of the Ugi-azide adduct

3-(4-Bromo-phen-yl)-1-butyl-5-[1-(2-chloro-6-methyl-phen-yl)-1H-tetra-zol-5-yl]imidazolidine-2,4-dione

Synthesis of Diverse Nitrogen-Enriched Heterocyclic Scaffolds Using a Suite of Tunable One-Pot Multicomponent Reactions

From one to two quaternary centers: Ester or nitrile α-alkylation applied to bioactive alkaloids

Facile and rapid route for the synthesis of novel norstatine analogs via PADAM-cyclization methodology

Branching cascades provide access to two amino-oxazoline compound libraries

Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound

Design and Synthesis of Fsp(3)-Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

Inhibitors to Overcome Secondary Mutations in the Stem Cell Factor Receptor KIT

Abstract 2661: Novel albumin-binding maytansinoids inducing long-term partial and complete tumor regressions in several human cancer xenograft models in nude mice

Abstract 3703: Superior efficacy of novel albumin-binding auristatin E-based prodrugs compared to auristatin E in a panel of human xenograft models in mice

Abstract 1657: Structure-activity relationship studies and biological evaluation of novel maytansinoids, a class of highly selective tubulin inhibitors

Facile and rapid route for the synthesis of novel conformationally constrained norstatine analogs via PADAM-cyclization methodology

Design and Synthesis of Fsp 3 -Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

Total synthesis of dehaloperophoramidine using a highly diastereoselective Hosomi-Sakurai reaction

Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PGE2 production in cells

Gonadotropin-releasing hormone receptor levels and cell context affect tumor cell responses to agonist in vitro and in vivo

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