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PI3K inhibitors are finally coming of age

Nature reviews. Drug discovery, 2021-10, Vol.20 (10), p.741-769

2021

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hERG K(+) channels: structure, function, and clinical significance

Physiological reviews, 2012-07, Vol.92 (3), p.1393-1478

2012

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Design, Synthesis, and Biological Evaluation of MEK PROTACs

Journal of medicinal chemistry, 2020-01, Vol.63 (1), p.157-162

2020

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Author Correction: PI3K inhibitors are finally coming of age

Nature reviews. Drug discovery, 2021-10, Vol.20 (10), p.798-798

2021

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Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Journal of medicinal chemistry, 2014-03, Vol.57 (6), p.2746-2754

2014

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Development of a robust induced pluripotent stem cell atrial cardiomyocyte differentiation protocol to model atrial arrhythmia

Stem cell research & therapy, 2023-07, Vol.14 (1), p.183-183, Article 183

2023

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Evolution of PI3Kγ and δ Inhibitors for Inflammatory and Autoimmune Diseases

Journal of medicinal chemistry, 2019-05, Vol.62 (10), p.4783-4814

2019

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Multiple Interactions between Cytoplasmic Domains Regulate Slow Deactivation of Kv11.1 Channels

The Journal of biological chemistry, 2014-09, Vol.289 (37), p.25822-25832

2014

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Getting to the heart of hERG K+ channel gating

The Journal of physiology, 2015-06, Vol.593 (12), p.2575-2585

2015

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The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating

PloS one, 2012-02, Vol.7 (2), p.e31640-e31640

2012

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TECRL: connecting sequence to consequence for a new sudden cardiac death gene

EMBO molecular medicine, 2016-12, Vol.8 (12), p.1364-1365

2016

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Structural and conformational determinants of macrocycle cell permeability

Nature chemical biology, 2016-12, Vol.12 (12), p.1065

2016

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The S1 helix critically regulates the finely tuned gating of Kv11.1 channels

The Journal of biological chemistry, 2017-05, Vol.292 (18), p.7688-7705

2017

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The N-terminal tail of hERG contains an amphipathic α-helix that regulates channel deactivation

PloS one, 2011-01, Vol.6 (1), p.e16191

2011

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Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels

The Journal of general physiology, 2012-09, Vol.140 (3), p.293-306

2012

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Stabilization of protein-protein interactions in drug discovery

Expert opinion on drug discovery, 2017-09, Vol.12 (9), p.925-940

2017

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A class of highly selective inhibitors bind to an active state of PI3Kγ

Nature chemical biology, 2019-04, Vol.15 (4), p.348

2019

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Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3‑Kinase (PI3K)‑γ Inhibitors

Journal of medicinal chemistry, 2018-06, Vol.61 (12), p.5435-5441

2018

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Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B

PloS one, 2015-03, Vol.10 (3), p.e0121285

2015

Volltextzugriff (PDF)

Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092

Bioorganic & medicinal chemistry letters, 2012-11, Vol.22 (21), p.6694-6699

2012

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Discovery of AZD8154, a Dual PI3Kγδ Inhibitor for the Treatment of Asthma

Journal of medicinal chemistry, 2021-06, Vol.64 (12), p.8053-8075

2021

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C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels

PloS one, 2013-10, Vol.8 (10), p.e77032-e77032

2013

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Recent advances in understanding and prevention of sudden cardiac death [version 1; peer review: 2 approved]

F1000 research, 2017, Vol.6, p.1614-1614

2017

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Co-expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic events

Cardiovascular research, 2021-08, Vol.117 (10), p.2216-2227

2021

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Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein–Protein Interaction

ACS chemical biology, 2020-04, Vol.15 (4), p.1026-1035

2020

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PI3K inhibitors are finally coming of age

hERG K(+) channels: structure, function, and clinical significance

Design, Synthesis, and Biological Evaluation of MEK PROTACs

Author Correction: PI3K inhibitors are finally coming of age

Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Development of a robust induced pluripotent stem cell atrial cardiomyocyte differentiation protocol to model atrial arrhythmia

Evolution of PI3Kγ and δ Inhibitors for Inflammatory and Autoimmune Diseases

Multiple Interactions between Cytoplasmic Domains Regulate Slow Deactivation of Kv11.1 Channels

Getting to the heart of hERG K+ channel gating

The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating

TECRL: connecting sequence to consequence for a new sudden cardiac death gene

Structural and conformational determinants of macrocycle cell permeability

The S1 helix critically regulates the finely tuned gating of Kv11.1 channels

The N-terminal tail of hERG contains an amphipathic α-helix that regulates channel deactivation

Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels

Stabilization of protein-protein interactions in drug discovery

A class of highly selective inhibitors bind to an active state of PI3Kγ

Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3‑Kinase (PI3K)‑γ Inhibitors

Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B

Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092

Discovery of AZD8154, a Dual PI3Kγδ Inhibitor for the Treatment of Asthma

C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels

Recent advances in understanding and prevention of sudden cardiac death [version 1; peer review: 2 approved]

Co-expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic events

Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein–Protein Interaction

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