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Development of automated patch clamp assays to overcome the burden of variants of uncertain significance in inheritable arrhythmia syndromes

Frontiers in physiology, 2023-11, Vol.14, p.1294741-1294741

2023

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Arrhythmogenic effects of ultra-long and bistable cardiac action potentials

PLoS computational biology, 2021-02, Vol.17 (2), p.e1008683-e1008683

2021

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High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11.1

Heart rhythm, 2020-12, Vol.17 (12), p.2180-2189

2020

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Domain Reorientation and Rotation of an Intracellular Assembly Regulate Conduction in Kir Potassium Channels

Cell, 2010-06, Vol.141 (6), p.1018-1029

2010

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Experimentally Validated Pharmacoinformatics Approach to Predict hERG Inhibition Potential of New Chemical Entities

Frontiers in pharmacology, 2018-09, Vol.9, p.1035-1035

2018

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TECRL: connecting sequence to consequence for a new sudden cardiac death gene

EMBO molecular medicine, 2016-12, Vol.8 (12), p.1364-1365

2016

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In Vitro and In Silico Risk Assessment in Acquired Long QT Syndrome: The Devil Is in the Details

Frontiers in physiology, 2017-11, Vol.8, p.934-934

2017

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The yin and yang of Tbx5 variant effects on sodium channel function

Cardiovascular research, 2022-03, Vol.118 (4), p.929-931

2022

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Slowed Conduction and Ventricular Tachycardia after Targeted Disruption of the Cardiac Sodium Channel Gene Scn5a

Proceedings of the National Academy of Sciences - PNAS, 2002-04, Vol.99 (9), p.6210-6215

2002

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Recent advances in understanding and prevention of sudden cardiac death [version 1; peer review: 2 approved]

F1000 research, 2017, Vol.6, p.1614-1614

2017

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Heritability of ECG Biomarkers in the Netherlands Twin Registry Measured from Holter ECGs

Frontiers in physiology, 2016-04, Vol.7, p.154-154

2016

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Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a

The Journal of physiology, 2005-09, Vol.567 (2), p.387-400

2005

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When it takes two to get one into trouble

Heart rhythm, 2022-02, Vol.19 (2), p.293-294

2022

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Protocol-Dependent Differences in IC50 Values Measured in Human Ether-Á-Go-Go-Related Gene Assays Occur in a Predictable Way and Can Be Used to Quantify State Preference of Drug Binding

Molecular pharmacology, 2019-05, Vol.95 (5), p.537-550

2019

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Substrate Specificity of Platypus Venom L-to-D-Peptide Isomerase

The Journal of biological chemistry, 2008-04, Vol.283 (14), p.8969-8975

2008

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Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics

The Journal of physiology, 2018-05, Vol.596 (10), p.1813-1828

2018

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High throughput measurement of hERG drug block kinetics using the CiPA dynamic protocol

Journal of pharmacological and toxicological methods, 2022-09, Vol.117, p.107192-107192, Article 107192

2022

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Electrogram prolongation and nifedipine-suppressible ventricular arrhythmias in mice following targeted disruption of KCNE1

The Journal of physiology, 2003-10, Vol.552 (2), p.535-546

2003

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Protocol-Dependent Differences in IC 50 Values Measured in Human Ether-Á-Go-Go-Related Gene Assays Occur in a Predictable Way and Can Be Used to Quantify State Preference of Drug Binding

Molecular pharmacology, 2019-05, Vol.95 (5), p.537-550

2019

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An ‘alternans’ way to quantify arrhythmogenic substrates

The Journal of physiology, 2016-05, Vol.594 (9), p.2375-2376

2016

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Temperature Effects on Kinetics of KV11.1 Drug Block Have Important Consequences for In Silico Proarrhythmic Risk Prediction

Molecular pharmacology, 2016-07, Vol.90 (1), p.1-11

2016

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Mutant MiRP1 subunits modulate HERG K+ channel gating: a mechanism for pro-arrhythmia in long QT syndrome type 6

The Journal of physiology, 2003-08, Vol.551 (1), p.253-262

2003

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Measuring kinetics and potency of hERG block for CiPA

Journal of pharmacological and toxicological methods, 2017-09, Vol.87, p.99-107

2017

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Kinetics of drug interaction with the Kv11.1 potassium channel

Molecular pharmacology, 2014-05, Vol.85 (5), p.769-776

2014

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Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels

The Journal of general physiology, 2013-09, Vol.142 (3), p.275-288

2013

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Development of automated patch clamp assays to overcome the burden of variants of uncertain significance in inheritable arrhythmia syndromes

Arrhythmogenic effects of ultra-long and bistable cardiac action potentials

High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11.1

Domain Reorientation and Rotation of an Intracellular Assembly Regulate Conduction in Kir Potassium Channels

Experimentally Validated Pharmacoinformatics Approach to Predict hERG Inhibition Potential of New Chemical Entities

TECRL: connecting sequence to consequence for a new sudden cardiac death gene

In Vitro and In Silico Risk Assessment in Acquired Long QT Syndrome: The Devil Is in the Details

The yin and yang of Tbx5 variant effects on sodium channel function

Slowed Conduction and Ventricular Tachycardia after Targeted Disruption of the Cardiac Sodium Channel Gene Scn5a

Recent advances in understanding and prevention of sudden cardiac death [version 1; peer review: 2 approved]

Heritability of ECG Biomarkers in the Netherlands Twin Registry Measured from Holter ECGs

Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a

When it takes two to get one into trouble

Protocol-Dependent Differences in IC50 Values Measured in Human Ether-Á-Go-Go-Related Gene Assays Occur in a Predictable Way and Can Be Used to Quantify State Preference of Drug Binding

Substrate Specificity of Platypus Venom L-to-D-Peptide Isomerase

Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics

High throughput measurement of hERG drug block kinetics using the CiPA dynamic protocol

Electrogram prolongation and nifedipine-suppressible ventricular arrhythmias in mice following targeted disruption of KCNE1

Protocol-Dependent Differences in IC 50 Values Measured in Human Ether-Á-Go-Go-Related Gene Assays Occur in a Predictable Way and Can Be Used to Quantify State Preference of Drug Binding

An ‘alternans’ way to quantify arrhythmogenic substrates

Temperature Effects on Kinetics of KV11.1 Drug Block Have Important Consequences for In Silico Proarrhythmic Risk Prediction

Mutant MiRP1 subunits modulate HERG K+ channel gating: a mechanism for pro-arrhythmia in long QT syndrome type 6

Measuring kinetics and potency of hERG block for CiPA

Kinetics of drug interaction with the Kv11.1 potassium channel

Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels

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