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Finding New Tricks For Old Drugs: An Efficient Route For Public-Sector Drug Discovery

Nature reviews. Drug discovery, 2005-12, Vol.4 (12), p.1005-1014

2005

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How Ligands Illuminate GPCR Molecular Pharmacology

Cell, 2017-07, Vol.170 (3), p.414-427

2017

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Chemogenetic tools to interrogate brain functions

Annual review of neuroscience, 2014-01, Vol.37 (1), p.387-407

2014

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Structure-based discovery of opioid analgesics with reduced side effects

Nature (London), 2016-09, Vol.537 (7619), p.185-190

2016

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Discovery of new GPCR ligands to illuminate new biology

Nature chemical biology, 2017-11, Vol.13 (11), p.1143-1151

2017

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Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor

Cell, 2018-01, Vol.172 (1-2), p.55-67.e15

2018

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5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology

Cell, 2018-02, Vol.172 (4), p.719-730.e14

2018

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Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization

Nature neuroscience, 2011-01, Vol.14 (1), p.22-24

2011

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Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace

Neuropharmacology, 2018-05, Vol.134 (Pt A), p.101-107

2018

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Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

Nature reviews. Drug discovery, 2004-04, Vol.3 (4), p.353-359

2004

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Translating genome-wide association findings into new therapeutics for psychiatry

Nature neuroscience, 2016-11, Vol.19 (11), p.1392-1396

2016

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Functional selectivity and classical concepts of quantitative pharmacology

The Journal of pharmacology and experimental therapeutics, 2007-01, Vol.320 (1), p.1-13

2007

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Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats

Neuropsychopharmacology (New York, N.Y.), 2016-01, Vol.41 (2), p.402-409

2016

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Aripiprazole, A Novel Atypical Antipsychotic Drug with a Unique and Robust Pharmacology

Neuropsychopharmacology, 2003-08, Vol.28 (8), p.1400-1411

2003

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Nigrostriatal Dopaminergic Deficits and Hypokinesia Caused by Inactivation of the Familial Parkinsonism-Linked Gene DJ-1

Neuron (Cambridge, Mass.), 2005-02, Vol.45 (4), p.489-496

2005

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Salvinorin A: A Potent Naturally Occurring Nonnitrogenous κ Opioid Selective Agonist

Proceedings of the National Academy of Sciences - PNAS, 2002-09, Vol.99 (18), p.11934-11939

2002

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The Human Polyomavirus, JCV, Uses Serotonin Receptors to Infect Cells

Science (American Association for the Advancement of Science), 2004-11, Vol.306 (5700), p.1380-1383

2004

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Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons

The Journal of biological chemistry, 2003-10, Vol.278 (44), p.43628-43635

2003

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G-protein-coupled receptors at a glance

Journal of cell science, 2003-12, Vol.116 (Pt 24), p.4867-4869

2003

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HI-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs

Neuropsychopharmacology (New York, N.Y.), 2003-03, Vol.28 (3), p.519-526

2003

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Serotonin receptors represent highly favorable molecular targets for cognitive enhancement in schizophrenia and other disorders

Psychopharmacologia, 2004-06, Vol.174 (1), p.17-24

2004

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Discrepancies in Kappa Opioid Agonist Binding Revealed through PET Imaging

ACS chemical neuroscience, 2019-01, Vol.10 (1), p.384-395

2019

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Conference Report: Psychiatric Genomics Consortium Meeting: Pathways to Drugs, London, March 2017

Biological psychiatry (1969), 2018-09, Vol.84 (6), p.e49-e50

2018

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Evidence for the Preferential Involvement of 5-HT2A Serotonin Receptors in Stress- and Drug-Induced Dopamine Release in the Rat Medial Prefrontal Cortex

Neuropsychopharmacology (New York, N.Y.), 2006-02, Vol.31 (2), p.265-277

2006

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Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression

Biological psychiatry (1969), 1999-05, Vol.45 (9), p.1085-1098

1999

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Finding New Tricks For Old Drugs: An Efficient Route For Public-Sector Drug Discovery

How Ligands Illuminate GPCR Molecular Pharmacology

Chemogenetic tools to interrogate brain functions

Structure-based discovery of opioid analgesics with reduced side effects

Discovery of new GPCR ligands to illuminate new biology

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor

5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology

Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization

Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace

Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

Translating genome-wide association findings into new therapeutics for psychiatry

Functional selectivity and classical concepts of quantitative pharmacology

Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats

Aripiprazole, A Novel Atypical Antipsychotic Drug with a Unique and Robust Pharmacology

Nigrostriatal Dopaminergic Deficits and Hypokinesia Caused by Inactivation of the Familial Parkinsonism-Linked Gene DJ-1

Salvinorin A: A Potent Naturally Occurring Nonnitrogenous κ Opioid Selective Agonist

The Human Polyomavirus, JCV, Uses Serotonin Receptors to Infect Cells

Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons

G-protein-coupled receptors at a glance

HI-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs

Serotonin receptors represent highly favorable molecular targets for cognitive enhancement in schizophrenia and other disorders

Discrepancies in Kappa Opioid Agonist Binding Revealed through PET Imaging

Conference Report: Psychiatric Genomics Consortium Meeting: Pathways to Drugs, London, March 2017

Evidence for the Preferential Involvement of 5-HT2A Serotonin Receptors in Stress- and Drug-Induced Dopamine Release in the Rat Medial Prefrontal Cortex

Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression

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