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Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site

eLife, 2021-02, Vol.10

2021

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Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine

The Journal of clinical investigation, 2017-04, Vol.127 (4), p.1561-1573

2017

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Synthesis and Characterization of a Dual Kappa-Delta Opioid Receptor Agonist Analgesic Blocking Cocaine Reward Behavior

ACS chemical neuroscience, 2015-11, Vol.6 (11), p.1813-1824

2015

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Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects

Proceedings of the National Academy of Sciences - PNAS, 2011-12, Vol.108 (49), p.19778-19783

2011

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Binding preference at the μ-opioid receptor underlies distinct pharmacology of cyclopropyl versus valeryl analogs of fentanyl

Neuropharmacology, 2023-04, Vol.227, p.109442-109442, Article 109442

2023

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Oxidative Metabolism as a Modulator of Kratom’s Biological Actions

Journal of medicinal chemistry, 2021-11, Vol.64 (22), p.16553-16572

2021

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7‑Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects

ACS central science, 2019-06, Vol.5 (6), p.992-1001

2019

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Truncated mu opioid GPCR variant involvement in opioid-dependent and opioid-independent pain modulatory systems within the CNS

Proceedings of the National Academy of Sciences - PNAS, 2016-03, Vol.113 (13), p.3663-3668

2016

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Attenuated mRNA expression of inflammatory mediators in neonatal rat lung following lipopolysaccharide treatment

Journal of inflammation research, 2012-01, Vol.5 (default), p.99-109

2012

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Novel 6β-acylaminomorphinans with analgesic activity

European journal of medicinal chemistry, 2013-11, Vol.69, p.786-789

2013

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Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace

Neuropharmacology, 2018-05, Vol.134 (Pt A), p.101-107

2018

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Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β‑Arrestin‑2

Journal of medicinal chemistry, 2016-09, Vol.59 (18), p.8381-8397

2016

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Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy

Cell stem cell, 2023-05, Vol.30 (5), p.632-647.e10

2023

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Synthesis and Pharmacology of a Novel μ–δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template

Journal of medicinal chemistry, 2020-11, Vol.63 (22), p.13618-13637

2020

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Pharmacological Characterization of Levorphanol, a G-Protein Biased Opioid Analgesic

Anesthesia and analgesia, 2019-02, Vol.128 (2), p.365-373

2019

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Identification of Abundant and Evolutionarily Conserved Opioid Receptor Circular RNAs in the Nervous System Modulated by Morphine

Molecular pharmacology, 2019-08, Vol.96 (2), p.247-258

2019

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Characterizing mu Opioid Receptor Splice Variants Using Gene Targeting Rat Models Generated by Easi‐CRISPR

The FASEB journal, 2019-04, Vol.33 (S1), p.lb74-lb74

2019

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Genetic dissociation of morphine analgesia from hyperalgesia in mice

Psychopharmacology, 2017-06, Vol.234 (12), p.1891-1900

2017

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A Molecular-Level Investigation of the Effect of Sodium Ions on the Binding of Opioid Ligands to their Receptors

Biophysical journal, 2014-01, Vol.106 (2), p.105a-105a

2014

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Synthesis and Evaluation of Aryl-Naloxamide Opiate Analgesics Targeting Truncated Exon 11-Associated μ Opioid Receptor (MOR-1) Splice Variants

Journal of medicinal chemistry, 2012-07, Vol.55 (14), p.6352-6362

2012

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Pharmacologic characterization in the rat of a potent analgesic lacking respiratory depression, IBNtxA

The Journal of pharmacology and experimental therapeutics, 2014-09, Vol.350 (3), p.710

2014

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Genetic dissociation of morphine analgesia from hyperalgesia

Psychopharmacology, 2017-03, Vol.234 (12), p.1891-1900

2017

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Postnatal Development of Hepatic Innate Immune Response

Inflammation, 2011-12, Vol.34 (6), p.576-584

2011

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Synthesis of Carfentanil Amide Opioids Using the Ugi Multicomponent Reaction

ACS chemical neuroscience, 2015-09, Vol.6 (9), p.1570-1577

2015

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Synthesis and pharmacological evaluation of novel selective MOR agonist 6β-pyridinyl amidomorphines exhibiting long-lasting antinociception† †The authors declare no competing interests. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c6md00450d

MedChemComm, 2016-10, Vol.8 (1), p.152-157

2016

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Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site

Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine

Synthesis and Characterization of a Dual Kappa-Delta Opioid Receptor Agonist Analgesic Blocking Cocaine Reward Behavior

Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects

Binding preference at the μ-opioid receptor underlies distinct pharmacology of cyclopropyl versus valeryl analogs of fentanyl

Oxidative Metabolism as a Modulator of Kratom’s Biological Actions

7‑Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects

Truncated mu opioid GPCR variant involvement in opioid-dependent and opioid-independent pain modulatory systems within the CNS

Attenuated mRNA expression of inflammatory mediators in neonatal rat lung following lipopolysaccharide treatment

Novel 6β-acylaminomorphinans with analgesic activity

Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace

Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β‑Arrestin‑2

Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy

Synthesis and Pharmacology of a Novel μ–δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template

Pharmacological Characterization of Levorphanol, a G-Protein Biased Opioid Analgesic

Identification of Abundant and Evolutionarily Conserved Opioid Receptor Circular RNAs in the Nervous System Modulated by Morphine

Characterizing mu Opioid Receptor Splice Variants Using Gene Targeting Rat Models Generated by Easi‐CRISPR

Genetic dissociation of morphine analgesia from hyperalgesia in mice

A Molecular-Level Investigation of the Effect of Sodium Ions on the Binding of Opioid Ligands to their Receptors

Synthesis and Evaluation of Aryl-Naloxamide Opiate Analgesics Targeting Truncated Exon 11-Associated μ Opioid Receptor (MOR-1) Splice Variants

Pharmacologic characterization in the rat of a potent analgesic lacking respiratory depression, IBNtxA

Genetic dissociation of morphine analgesia from hyperalgesia

Postnatal Development of Hepatic Innate Immune Response

Synthesis of Carfentanil Amide Opioids Using the Ugi Multicomponent Reaction

Synthesis and pharmacological evaluation of novel selective MOR agonist 6β-pyridinyl amidomorphines exhibiting long-lasting antinociception† †The authors declare no competing interests. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c6md00450d

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