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Activation and allosteric modulation of a muscarinic acetylcholine receptor

Nature (London), 2013-12, Vol.504 (7478), p.101-106

2013

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Conformational Complexity and Dynamics in a Muscarinic Receptor Revealed by NMR Spectroscopy

Molecular cell, 2019-07, Vol.75 (1), p.53-65.e7

2019

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Binding pathway determines norepinephrine selectivity for the human β1AR over β2AR

Cell research, 2021-05, Vol.31 (5), p.569-579

2021

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Monitoring of the dopamine D2 receptor agonists hordenine and N-methyltyramine during the brewing process and in commercial beer samples

Food chemistry, 2019-03, Vol.276, p.745-753

2019

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Structure-based development of a subtype-selective orexin 1 receptor antagonist

Proceedings of the National Academy of Sciences - PNAS, 2020-07, Vol.117 (30), p.18059-18067

2020

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Structure and function of an irreversible agonist-β2 adrenoceptor complex

Nature (London), 2011-01, Vol.469 (7329), p.236-240

2011

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Structure-guided development of heterodimer-selective GPCR ligands

Nature communications, 2016-07, Vol.7 (1), p.12298-12298, Article 12298

2016

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Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists

Proceedings of the National Academy of Sciences - PNAS, 2018-11, Vol.115 (47), p.12046-12050

2018

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Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex

Nature communications, 2022-05, Vol.13 (1), p.2375-2375, Article 2375

2022

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Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor

Nature communications, 2023-01, Vol.14 (1), p.376-376, Article 376

2023

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Covalent agonists for studying G protein-coupled receptor activation

Proceedings of the National Academy of Sciences - PNAS, 2014-07, Vol.111 (29), p.10744-10748

2014

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Visualization and ligand-induced modulation of dopamine receptor dimerization at the single molecule level

Scientific reports, 2016-09, Vol.6 (1), p.33233-33233, Article 33233

2016

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Fluorescent ligands for dopamine D2/D3 receptors

Scientific reports, 2020-12, Vol.10 (1), p.21842-21842, Article 21842

2020

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Active-state model of a dopamine D2 receptor-Gαi complex stabilized by aripiprazole-type partial agonists

PloS one, 2014-06, Vol.9 (6), p.e100069-e100069

2014

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Visualization of ligand-induced dopamine D2S and D2L receptor internalization by TIRF microscopy

Scientific reports, 2017-09, Vol.7 (1), p.1-11, Article 10894

2017

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Constrained catecholamines gain β2AR selectivity through allosteric effects on pocket dynamics

Nature communications, 2023-04, Vol.14 (1), p.2138-2138, Article 2138

2023

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Active-state models of ternary GPCR complexes: determinants of selective receptor-G-protein coupling

PloS one, 2013-06, Vol.8 (6), p.e67244

2013

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Optimizing the Expression of Human Dopamine Receptors in Escherichia coli

International journal of molecular sciences, 2021-08, Vol.22 (16), p.8647

2021

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Structure-Based Design and Discovery of New M2 Receptor Agonists

Journal of medicinal chemistry, 2017-11, Vol.60 (22), p.9239-9250

2017

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Muscarinic Receptors as Model Targets and Antitargets for Structure-Based Ligand Discovery

Molecular pharmacology, 2013-10, Vol.84 (4), p.528-540

2013

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Functionally selective activation of the dopamine receptor D2 is mirrored by the protein expression profiles

Scientific reports, 2021-02, Vol.11 (1), p.3501-3501, Article 3501

2021

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Comparative MD Simulations Indicate a Dual Role for Arg1323.50 in Dopamine-Dependent D2R Activation

PloS one, 2016, Vol.11 (1), p.e0146612-e0146612

2016

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Dopamine D3 receptor ligands—Recent advances in the control of subtype selectivity and intrinsic activity

Biochimica et biophysica acta, 2007-04, Vol.1768 (4), p.871-887

2007

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Development of Covalent Ligand–Receptor Pairs to Study the Binding Properties of Nonpeptidic Neurotensin Receptor 1 Antagonists

ACS chemical biology, 2016-04, Vol.11 (4), p.869-875

2016

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Covalent Molecular Probes for Class A G Protein-Coupled Receptors: Advances and Applications

ACS chemical biology, 2015-06, Vol.10 (6), p.1376-1386

2015

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Activation and allosteric modulation of a muscarinic acetylcholine receptor

Conformational Complexity and Dynamics in a Muscarinic Receptor Revealed by NMR Spectroscopy

Binding pathway determines norepinephrine selectivity for the human β1AR over β2AR

Monitoring of the dopamine D2 receptor agonists hordenine and N-methyltyramine during the brewing process and in commercial beer samples

Structure-based development of a subtype-selective orexin 1 receptor antagonist

Structure and function of an irreversible agonist-β2 adrenoceptor complex

Structure-guided development of heterodimer-selective GPCR ligands

Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists

Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex

Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor

Covalent agonists for studying G protein-coupled receptor activation

Visualization and ligand-induced modulation of dopamine receptor dimerization at the single molecule level

Fluorescent ligands for dopamine D2/D3 receptors

Active-state model of a dopamine D2 receptor-Gαi complex stabilized by aripiprazole-type partial agonists

Visualization of ligand-induced dopamine D2S and D2L receptor internalization by TIRF microscopy

Constrained catecholamines gain β2AR selectivity through allosteric effects on pocket dynamics

Active-state models of ternary GPCR complexes: determinants of selective receptor-G-protein coupling

Optimizing the Expression of Human Dopamine Receptors in Escherichia coli

Structure-Based Design and Discovery of New M2 Receptor Agonists

Muscarinic Receptors as Model Targets and Antitargets for Structure-Based Ligand Discovery

Functionally selective activation of the dopamine receptor D2 is mirrored by the protein expression profiles

Comparative MD Simulations Indicate a Dual Role for Arg1323.50 in Dopamine-Dependent D2R Activation

Dopamine D3 receptor ligands—Recent advances in the control of subtype selectivity and intrinsic activity

Development of Covalent Ligand–Receptor Pairs to Study the Binding Properties of Nonpeptidic Neurotensin Receptor 1 Antagonists

Covalent Molecular Probes for Class A G Protein-Coupled Receptors: Advances and Applications

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