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Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR

Nature communications, 2022-06, Vol.13 (1), p.3586-3586, Article 3586

2022

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Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis

The Journal of clinical investigation, 2002-10, Vol.110 (7), p.1045-1052

2002

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Interspecies in vitro metabolism of the phosphodiesterase-4 (PDE4) inhibitor L-454,560

Journal of mass spectrometry., 2006-06, Vol.41 (6), p.771-780

2006

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Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis

The Journal of clinical investigation, 2002-10, Vol.110 (7), p.1045-1052

2002

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The next generation of PDE4 inhibitors

Current Opinion in Chemical Biology, 2001-08, Vol.5 (4), p.432-438

2001

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Notions of Genre: Writings on Popular Film Before Genre Theory

1, 2016

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Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (22), p.6387-6393

2010

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Whatever Happened to Hollywood Comedy

Notions of Genre, 2021, p.53-59

2021

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Design and synthesis of potent, isoxazole-containing renin inhibitors

Bioorganic & medicinal chemistry letters, 2012-04, Vol.22 (8), p.2670-2674

2012

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Addressing time-dependent CYP 3A4 inhibition observed in a novel series of substituted amino propanamide renin inhibitors, a case study

Bioorganic & medicinal chemistry letters, 2010-09, Vol.20 (17), p.5074-5079

2010

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Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents

Bioorganic & medicinal chemistry letters, 2011-09, Vol.21 (18), p.5547-5551

2011

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Renin inhibitors for the treatment of hypertension: Design and optimization of a novel series of pyridone-substituted piperidines

Bioorganic & medicinal chemistry letters, 2011-07, Vol.21 (13), p.3970-3975

2011

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Renin inhibitors for the treatment of hypertension: Design and optimization of a novel series of tertiary alcohol-bearing piperidines

Bioorganic & medicinal chemistry letters, 2011-07, Vol.21 (13), p.3976-3981

2011

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Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (7), p.2204-2209

2010

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The discovery and synthesis of potent zwitterionic inhibitors of renin

Bioorganic & medicinal chemistry letters, 2011-04, Vol.21 (8), p.2430-2436

2011

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Total synthesis of (+)-ikarugamycin. 2. Elaboration of the macrocyclic lactam and tetramic acid substructures and complete assembly of the antibiotic

Journal of the American Chemical Society, 1990-12, Vol.112 (25), p.9292-9299

1990

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Enantiomer Discrimination Illustrated by the High Resolution Crystal Structures of Type 4 Phosphodiesterase

Journal of medicinal chemistry, 2006-03, Vol.49 (6), p.1867-1873

2006

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A highly stereoselective Diels-Alder based synthesis of (.+-.)-podophyllotoxin

Journal of organic chemistry, 1986-11, Vol.51 (24), p.4749-4750

1986

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Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein

Bioorganic & medicinal chemistry, 2008-03, Vol.18 (6), p.2023-2027

2008

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WHATEVER HAPPENED TO HOLLYWOOD COMEDY?

Notions of Genre, 2016, p.53

2016

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Le cinéma soviétique : une histoire et une élégie

Agone : philosophie, critique, & littérature, 2012-04 (48), p.201-232

Macdonald, Dwight

2012

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Process Development and Large-Scale Synthesis of a PDE4 Inhibitor

Organic process research & development, 2006-01, Vol.10 (1), p.36-45

2006

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Design, synthesis, and biological evaluation of 8-biarylquinolines: A novel class of PDE4 inhibitors

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (4), p.1407-1412

2008

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Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (17), p.5266-5269

2009

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Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR

Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis

Interspecies in vitro metabolism of the phosphodiesterase-4 (PDE4) inhibitor L-454,560

Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis

The next generation of PDE4 inhibitors

Notions of Genre: Writings on Popular Film Before Genre Theory

Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment

Whatever Happened to Hollywood Comedy

Design and synthesis of potent, isoxazole-containing renin inhibitors

Addressing time-dependent CYP 3A4 inhibition observed in a novel series of substituted amino propanamide renin inhibitors, a case study

Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents

Renin inhibitors for the treatment of hypertension: Design and optimization of a novel series of pyridone-substituted piperidines

Renin inhibitors for the treatment of hypertension: Design and optimization of a novel series of tertiary alcohol-bearing piperidines

Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension

The discovery and synthesis of potent zwitterionic inhibitors of renin

Total synthesis of (+)-ikarugamycin. 2. Elaboration of the macrocyclic lactam and tetramic acid substructures and complete assembly of the antibiotic

Enantiomer Discrimination Illustrated by the High Resolution Crystal Structures of Type 4 Phosphodiesterase

A highly stereoselective Diels-Alder based synthesis of (.+-.)-podophyllotoxin

Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein

WHATEVER HAPPENED TO HOLLYWOOD COMEDY?

Le cinéma soviétique : une histoire et une élégie

Process Development and Large-Scale Synthesis of a PDE4 Inhibitor

Design, synthesis, and biological evaluation of 8-biarylquinolines: A novel class of PDE4 inhibitors

Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors

Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: Structure–activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor

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