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Metabolism and Functions of Inositol Pyrophosphates: Insights Gained from the Application of Synthetic Analogues

Molecules (Basel, Switzerland), 2020-10, Vol.25 (19), p.4515

2020

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Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

Cell, 2011-09, Vol.147 (1), p.223-234

2011

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Inositol phosphate kinases: Expanding the biological significance of the universal core of the protein kinase fold

Advances in biological regulation, 2019-01, Vol.71, p.118-127

2019

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Crystal structures of phosphodiesterases and implications on substrate specificity and inhibitor selectivity

Current topics in medicinal chemistry, 2007-02, Vol.7 (4), p.391

2007

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Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte

Development (Cambridge), 2009-06, Vol.136 (11), p.1869-1878

2009

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Synthesis of Densely Phosphorylated Bis-1,5-Diphospho-myo-Inositol Tetrakisphosphate and its Enantiomer by Bidirectional P-Anhydride Formation

Angewandte Chemie (International ed.), 2014-09, Vol.53 (36), p.9508-9511

International ed. in English, 2014

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Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line

Proceedings of the National Academy of Sciences - PNAS, 2021-03, Vol.118 (10), p.1

2021

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A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop

Nature communications, 2022-04, Vol.13 (1), p.2231-2231, Article 2231

2022

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High-resolution design of a protein loop

Proceedings of the National Academy of Sciences - PNAS, 2007-11, Vol.104 (45), p.17668-17673

2007

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Structural insight into substrate specificity of phosphodiesterase 10

Proceedings of the National Academy of Sciences - PNAS, 2007-04, Vol.104 (14), p.5782-5787

2007

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Kinetic and Structural Studies of Phosphodiesterase-8A and Implication on the Inhibitor Selectivity

Biochemistry (Easton), 2008-12, Vol.47 (48), p.12760-12768

2008

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Crystallographic and Nuclear Magnetic Resonance Evaluation of the Impact of Peptide Binding to the Second PDZ Domain of Protein Tyrosine Phosphatase 1E

Biochemistry (Easton), 2010-11, Vol.49 (43), p.9280-9291

2010

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The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment

Bioscience reports, 2013-02, Vol.33 (2), p.e00022

2013

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Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors

Molecular microbiology, 2007-11, Vol.66 (4), p.1029-1038

2007

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Retraction: A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors

PloS one, 2017-06, Vol.12 (6), p.e0180272-e0180272

2017

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A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors

PloS one, 2016-10, Vol.11 (10), p.e0164378

2016

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Conformational Variations of Both Phosphodiesterase-5 and Inhibitors Provide the Structural Basis for the Physiological Effects of Vardenafil and Sildenafil

Molecular pharmacology, 2008-01, Vol.73 (1), p.104-110

2008

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Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis

Journal of medicinal chemistry, 2010-02, Vol.53 (4), p.1726-1731

2010

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Design, Synthesis, and Structure−Activity Relationship, Molecular Modeling, and NMR Studies of a Series of Phenyl Alkyl Ketones as Highly Potent and Selective Phosphodiesterase-4 Inhibitors

Journal of medicinal chemistry, 2008-12, Vol.51 (24), p.7673-7688

2008

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Multiple Elements Jointly Determine Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases 4 and 7

The Journal of biological chemistry, 2005-09, Vol.280 (35), p.30949-30955

2005

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Structural and catalytic analyses of the InsP6 kinase activities of higher plant ITPKs

The FASEB journal, 2022-07, Vol.36 (7), p.e22380-n/a

2022

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Crystal Structure of Phosphodiesterase 9 Shows Orientation Variation of Inhibitor 3-Isobutyl-1-Methylxanthine Binding

Proceedings of the National Academy of Sciences - PNAS, 2004-06, Vol.101 (26), p.9624-9629

2004

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Structural and catalytic analyses of the InsP 6 kinase activities of higher plant ITPKs

The FASEB journal, 2022-07, Vol.36 (7), p.e22380

2022

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An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies

Biochemical pharmacology, 2008-05, Vol.75 (9), p.1717-1728

2008

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Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities

The Journal of biological chemistry, 2017-11, Vol.292 (44), p.18192-18202

2017

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Metabolism and Functions of Inositol Pyrophosphates: Insights Gained from the Application of Synthetic Analogues

Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

Inositol phosphate kinases: Expanding the biological significance of the universal core of the protein kinase fold

Crystal structures of phosphodiesterases and implications on substrate specificity and inhibitor selectivity

Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte

Synthesis of Densely Phosphorylated Bis-1,5-Diphospho-myo-Inositol Tetrakisphosphate and its Enantiomer by Bidirectional P-Anhydride Formation

Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line

A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop

High-resolution design of a protein loop

Structural insight into substrate specificity of phosphodiesterase 10

Kinetic and Structural Studies of Phosphodiesterase-8A and Implication on the Inhibitor Selectivity

Crystallographic and Nuclear Magnetic Resonance Evaluation of the Impact of Peptide Binding to the Second PDZ Domain of Protein Tyrosine Phosphatase 1E

The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment

Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors

Retraction: A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors

A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors

Conformational Variations of Both Phosphodiesterase-5 and Inhibitors Provide the Structural Basis for the Physiological Effects of Vardenafil and Sildenafil

Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis

Design, Synthesis, and Structure−Activity Relationship, Molecular Modeling, and NMR Studies of a Series of Phenyl Alkyl Ketones as Highly Potent and Selective Phosphodiesterase-4 Inhibitors

Multiple Elements Jointly Determine Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases 4 and 7

Structural and catalytic analyses of the InsP6 kinase activities of higher plant ITPKs

Crystal Structure of Phosphodiesterase 9 Shows Orientation Variation of Inhibitor 3-Isobutyl-1-Methylxanthine Binding

Structural and catalytic analyses of the InsP 6 kinase activities of higher plant ITPKs

An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies

Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities

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