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Design, Synthesis, and Biological Evaluation of MEK PROTACs

Journal of medicinal chemistry, 2020-01, Vol.63 (1), p.157-162

2020

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TECRL: connecting sequence to consequence for a new sudden cardiac death gene

EMBO molecular medicine, 2016-12, Vol.8 (12), p.1364-1365

2016

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Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3‑Kinase (PI3K)‑γ Inhibitors

Journal of medicinal chemistry, 2018-06, Vol.61 (12), p.5435-5441

2018

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Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B

PloS one, 2015-03, Vol.10 (3), p.e0121285

2015

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Recent advances in understanding and prevention of sudden cardiac death [version 1; peer review: 2 approved]

F1000 research, 2017, Vol.6, p.1614-1614

2017

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Protocol-Dependent Differences in IC50 Values Measured in Human Ether-Á-Go-Go-Related Gene Assays Occur in a Predictable Way and Can Be Used to Quantify State Preference of Drug Binding

Molecular pharmacology, 2019-05, Vol.95 (5), p.537-550

2019

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Using many different voltage protocols to characterise discrepancy in mathematical ion channel models

Biophysical journal, 2023-02, Vol.122 (3), p.242a-242a

2023

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Design and Synthesis of Soluble and Cell-Permeable PI3Kδ Inhibitors for Long-Acting Inhaled Administration

Journal of medicinal chemistry, 2017-06, Vol.60 (12), p.5057-5071

2017

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Spiro-fused Pyrrolidine, Piperidine, and Oxindole Scaffolds from Lactams

Organic letters, 2012-09, Vol.14 (18), p.4846-4849

2012

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14-3-3 modulation of the inflammatory response

Pharmacological research, 2021-01, Vol.163, p.105236-105236, Article 105236

2021

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Action Potential Morphology Accurately Predicts Proarrhythmic Risk for Drugs With Potential to Prolong Cardiac Repolarization

Circulation. Arrhythmia and electrophysiology, 2023-07, Vol.16 (7), p.399-410

2023

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Protocol-Dependent Differences in IC 50 Values Measured in Human Ether-Á-Go-Go-Related Gene Assays Occur in a Predictable Way and Can Be Used to Quantify State Preference of Drug Binding

Molecular pharmacology, 2019-05, Vol.95 (5), p.537-550

2019

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Designing novel building blocks is an overlooked strategy to improve compound quality

Drug discovery today, 2015-01, Vol.20 (1), p.11-17

2015

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Surprising lipophilicity observations identify unexpected conformational effects

Bioorganic & medicinal chemistry letters, 2022-08, Vol.69, p.128786, Article 128786

2022

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Segmental differences in upregulated apical potassium channels in mammalian colon during potassium adaptation

American journal of physiology: Gastrointestinal and liver physiology, 2016-11, Vol.311 (5), p.G785-G793

2016

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Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels

The Journal of general physiology, 2013-09, Vol.142 (3), p.275-288

2013

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Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3‑3 Protein–Protein Interaction

Journal of medicinal chemistry, 2022-12, Vol.65 (24), p.16818-16828

2022

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Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-throughput automated patch clamp electrophysiology

Biology methods and protocols, 2021, Vol.6 (1), p.bpab003-bpab003

2021

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Correction to “Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3‑3 Protein–Protein Interaction”

Journal of medicinal chemistry, 2023-02, Vol.66 (3), p.2205-2207

2023

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A Practical Method for Targeted Library Design Balancing Lead-like Properties with Diversity

ChemMedChem, 2009-05, Vol.4 (5), p.800-808

2009

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Using Clinical Datasets to Optimize Models of Human Ventricular Electrophysiology: Implications for In Silico Drug Screening

Biophysical journal, 2017-02, Vol.112 (3), p.465a-465a

2017

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Critical Dual Role for the Pore Helix in Kv11.1 Channel Inactivation

Biophysical journal, 2012-01, Vol.102 (3), p.328a-328a

2012

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Steady-State Modulation of Voltage-Gated K.sup.+ Channels in Rat Arterial Smooth Muscle by Cyclic AMP-Dependent Protein Kinase and Protein Phosphatase 2B

PloS one, 2015-03, Vol.10 (3)

2015

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Mechanism Of Action For The hERG Potassium Channel Activator, PD-118057

Biophysical journal, 2009-02, Vol.96 (3), p.188a-188a

2009

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The S4-S5 Linker Acts as a Signal Integrator for hERG K.sup.+ Channel Activation and Deactivation Gating

PloS one, 2012-02, Vol.7 (2), p.e31640

2012

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Design, Synthesis, and Biological Evaluation of MEK PROTACs

TECRL: connecting sequence to consequence for a new sudden cardiac death gene

Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3‑Kinase (PI3K)‑γ Inhibitors

Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B

Recent advances in understanding and prevention of sudden cardiac death [version 1; peer review: 2 approved]

Protocol-Dependent Differences in IC50 Values Measured in Human Ether-Á-Go-Go-Related Gene Assays Occur in a Predictable Way and Can Be Used to Quantify State Preference of Drug Binding

Using many different voltage protocols to characterise discrepancy in mathematical ion channel models

Design and Synthesis of Soluble and Cell-Permeable PI3Kδ Inhibitors for Long-Acting Inhaled Administration

Spiro-fused Pyrrolidine, Piperidine, and Oxindole Scaffolds from Lactams

14-3-3 modulation of the inflammatory response

Action Potential Morphology Accurately Predicts Proarrhythmic Risk for Drugs With Potential to Prolong Cardiac Repolarization

Protocol-Dependent Differences in IC 50 Values Measured in Human Ether-Á-Go-Go-Related Gene Assays Occur in a Predictable Way and Can Be Used to Quantify State Preference of Drug Binding

Designing novel building blocks is an overlooked strategy to improve compound quality

Surprising lipophilicity observations identify unexpected conformational effects

Segmental differences in upregulated apical potassium channels in mammalian colon during potassium adaptation

Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels

Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3‑3 Protein–Protein Interaction

Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-throughput automated patch clamp electrophysiology

Correction to “Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3‑3 Protein–Protein Interaction”

A Practical Method for Targeted Library Design Balancing Lead-like Properties with Diversity

Using Clinical Datasets to Optimize Models of Human Ventricular Electrophysiology: Implications for In Silico Drug Screening

Critical Dual Role for the Pore Helix in Kv11.1 Channel Inactivation

Steady-State Modulation of Voltage-Gated K.sup.+ Channels in Rat Arterial Smooth Muscle by Cyclic AMP-Dependent Protein Kinase and Protein Phosphatase 2B

Mechanism Of Action For The hERG Potassium Channel Activator, PD-118057

The S4-S5 Linker Acts as a Signal Integrator for hERG K.sup.+ Channel Activation and Deactivation Gating

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