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Getting to the heart of hERG K+ channel gating

The Journal of physiology, 2015-06, Vol.593 (12), p.2575-2585

2015

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Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092

Bioorganic & medicinal chemistry letters, 2012-11, Vol.22 (21), p.6694-6699

2012

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Co-expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic events

Cardiovascular research, 2021-08, Vol.117 (10), p.2216-2227

2021

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Pathophysiological metabolic changes associated with disease modify the proarrhythmic risk profile of drugs with potential to prolong repolarisation

British journal of pharmacology, 2022-06, Vol.179 (11), p.2631-2646

2022

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Using many different voltage protocols to characterise discrepancy in mathematical ion channel models

Biophysical journal, 2023-02, Vol.122 (3), p.242a-242a

2023

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Pharmacological activation of IKr in models of long QT Type 2 risks overcorrection of repolarization

Cardiovascular research, 2020-07, Vol.116 (8), p.1434-1445

2020

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High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants

Heart rhythm, 2020-03, Vol.17 (3), p.492-500

2020

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Action Potential Morphology Accurately Predicts Proarrhythmic Risk for Drugs With Potential to Prolong Cardiac Repolarization

Circulation. Arrhythmia and electrophysiology, 2023-07, Vol.16 (7), p.399

2023

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14-3-3 modulation of the inflammatory response

Pharmacological research, 2021-01, Vol.163, p.105236-105236, Article 105236

2021

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Convergence of models of human ventricular myocyte electrophysiology after global optimization to recapitulate clinical long QT phenotypes

Journal of molecular and cellular cardiology, 2016-11, Vol.100, p.25-34

2016

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Designing novel building blocks is an overlooked strategy to improve compound quality

Drug discovery today, 2015-01, Vol.20 (1), p.11-17

2015

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Rescue of protein expression defects may not be enough to abolish the pro‐arrhythmic phenotype of long QT type 2 mutations

The Journal of physiology, 2016-07, Vol.594 (14), p.4031-4049

2016

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Surprising lipophilicity observations identify unexpected conformational effects

Bioorganic & medicinal chemistry letters, 2022-08, Vol.69, p.128786, Article 128786

2022

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Can many subunits make light work of ion channel inactivation?

The Journal of physiology, 2014-10, Vol.592 (20), p.4411-4412

2014

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Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century

The Journal of physiology, 2016-12, Vol.594 (23), p.6893-6908

2016

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Principal role of adenylyl cyclase 6 in K+ channel regulation and vasodilator signalling in vascular smooth muscle cells

Cardiovascular research, 2011-09, Vol.91 (4), p.694-702

2011

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The discovery of CCR3/H1 dual antagonists with reduced hERG risk

Bioorganic & medicinal chemistry letters, 2012-11, Vol.22 (21), p.6688-6693

2012

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Using Clinical Datasets to Optimize Models of Human Ventricular Electrophysiology: Implications for In Silico Drug Screening

Biophysical journal, 2017-02, Vol.112 (3), p.465a-465a

2017

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Critical Dual Role for the Pore Helix in Kv11.1 Channel Inactivation

Biophysical journal, 2012-01, Vol.102 (3), p.328a-328a

2012

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On the absolute configuration of 1-cyclopropylethan-1-amine

Tetrahedron: asymmetry, 2017-09, Vol.28 (9), p.1135-1138

2017

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Mechanism Of Action For The hERG Potassium Channel Activator, PD-118057

Biophysical journal, 2009-02, Vol.96 (3), p.188a-188a

2009

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Somatostatin inhibits high conductance colonic apical potassium channels via G protein-dependent tyrosine dephosphorylation

Gastroenterology (New York, N.Y. 1943), 2001-04, Vol.120 (5), p.A313-A313

2001

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The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection

Immunity (Cambridge, Mass.), 2014-11, Vol.41 (5), p.802-814

2014

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Degraded RNA from Human Anterior Cruciate Ligaments Yields Valid Gene Expression Profiles

International journal of molecular sciences, 2023-01, Vol.24 (3), p.1895

2023

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Impaired mitophagy facilitates mitochondrial damage in Danon disease

Journal of molecular and cellular cardiology, 2017-07, Vol.108, p.86-94

2017

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Getting to the heart of hERG K+ channel gating

Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092

Co-expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic events

Pathophysiological metabolic changes associated with disease modify the proarrhythmic risk profile of drugs with potential to prolong repolarisation

Using many different voltage protocols to characterise discrepancy in mathematical ion channel models

Pharmacological activation of IKr in models of long QT Type 2 risks overcorrection of repolarization

High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants

Action Potential Morphology Accurately Predicts Proarrhythmic Risk for Drugs With Potential to Prolong Cardiac Repolarization

14-3-3 modulation of the inflammatory response

Convergence of models of human ventricular myocyte electrophysiology after global optimization to recapitulate clinical long QT phenotypes

Designing novel building blocks is an overlooked strategy to improve compound quality

Rescue of protein expression defects may not be enough to abolish the pro‐arrhythmic phenotype of long QT type 2 mutations

Surprising lipophilicity observations identify unexpected conformational effects

Can many subunits make light work of ion channel inactivation?

Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century

Principal role of adenylyl cyclase 6 in K+ channel regulation and vasodilator signalling in vascular smooth muscle cells

The discovery of CCR3/H1 dual antagonists with reduced hERG risk

Using Clinical Datasets to Optimize Models of Human Ventricular Electrophysiology: Implications for In Silico Drug Screening

Critical Dual Role for the Pore Helix in Kv11.1 Channel Inactivation

On the absolute configuration of 1-cyclopropylethan-1-amine

Mechanism Of Action For The hERG Potassium Channel Activator, PD-118057

Somatostatin inhibits high conductance colonic apical potassium channels via G protein-dependent tyrosine dephosphorylation

The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection

Degraded RNA from Human Anterior Cruciate Ligaments Yields Valid Gene Expression Profiles

Impaired mitophagy facilitates mitochondrial damage in Danon disease

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