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PI3K inhibitors are finally coming of age

Nature reviews. Drug discovery, 2021-10, Vol.20 (10), p.741-769

2021

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hERG K(+) channels: structure, function, and clinical significance

Physiological reviews, 2012-07, Vol.92 (3), p.1393-1478

2012

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Design, Synthesis, and Biological Evaluation of MEK PROTACs

Journal of medicinal chemistry, 2020-01, Vol.63 (1), p.157-162

2020

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Author Correction: PI3K inhibitors are finally coming of age

Nature reviews. Drug discovery, 2021-10, Vol.20 (10), p.798-798

2021

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Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Journal of medicinal chemistry, 2014-03, Vol.57 (6), p.2746-2754

2014

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Development of a robust induced pluripotent stem cell atrial cardiomyocyte differentiation protocol to model atrial arrhythmia

Stem cell research & therapy, 2023-07, Vol.14 (1), p.183-183, Article 183

2023

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Evolution of PI3Kγ and δ Inhibitors for Inflammatory and Autoimmune Diseases

Journal of medicinal chemistry, 2019-05, Vol.62 (10), p.4783-4814

2019

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Multiple Interactions between Cytoplasmic Domains Regulate Slow Deactivation of Kv11.1 Channels

The Journal of biological chemistry, 2014-09, Vol.289 (37), p.25822-25832

2014

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TECRL: connecting sequence to consequence for a new sudden cardiac death gene

EMBO molecular medicine, 2016-12, Vol.8 (12), p.1364-1365

2016

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The S1 helix critically regulates the finely tuned gating of Kv11.1 channels

The Journal of biological chemistry, 2017-05, Vol.292 (18), p.7688-7705

2017

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Structural and conformational determinants of macrocycle cell permeability

Nature chemical biology, 2016-12, Vol.12 (12), p.1065

2016

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Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels

The Journal of general physiology, 2012-09, Vol.140 (3), p.293-306

2012

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Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3‑Kinase (PI3K)‑γ Inhibitors

Journal of medicinal chemistry, 2018-06, Vol.61 (12), p.5435-5441

2018

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A class of highly selective inhibitors bind to an active state of PI3Kγ

Nature chemical biology, 2019-04, Vol.15 (4), p.348

2019

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Recent advances in understanding and prevention of sudden cardiac death [version 1; peer review: 2 approved]

F1000 research, 2017, Vol.6, p.1614-1614

2017

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Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein–Protein Interaction

ACS chemical biology, 2020-04, Vol.15 (4), p.1026-1035

2020

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Protocol-Dependent Differences in IC50 Values Measured in Human Ether-Á-Go-Go-Related Gene Assays Occur in a Predictable Way and Can Be Used to Quantify State Preference of Drug Binding

Molecular pharmacology, 2019-05, Vol.95 (5), p.537-550

2019

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Design and Synthesis of Soluble and Cell-Permeable PI3Kδ Inhibitors for Long-Acting Inhaled Administration

Journal of medicinal chemistry, 2017-06, Vol.60 (12), p.5057-5071

2017

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Spiro-fused Pyrrolidine, Piperidine, and Oxindole Scaffolds from Lactams

Organic letters, 2012-09, Vol.14 (18), p.4846-4849

2012

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Protocol-Dependent Differences in IC 50 Values Measured in Human Ether-Á-Go-Go-Related Gene Assays Occur in a Predictable Way and Can Be Used to Quantify State Preference of Drug Binding

Molecular pharmacology, 2019-05, Vol.95 (5), p.537-550

2019

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Pore Helices Play a Dynamic Role as Integrators of Domain Motion during Kv11.1 Channel Inactivation Gating

The Journal of biological chemistry, 2013-04, Vol.288 (16), p.11482-11491

2013

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Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2

Nature communications, 2014-09, Vol.5 (1), p.5069-5069, Article 5069

2014

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Segmental differences in upregulated apical potassium channels in mammalian colon during potassium adaptation

American journal of physiology: Gastrointestinal and liver physiology, 2016-11, Vol.311 (5), p.G785-G793

2016

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Role of the Cytoplasmic N-terminal Cap and Per-Arnt-Sim (PAS) Domain in Trafficking and Stabilization of Kv11.1 Channels

The Journal of biological chemistry, 2014-05, Vol.289 (20), p.13782-13791

2014

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PI3K inhibitors are finally coming of age

hERG K(+) channels: structure, function, and clinical significance

Design, Synthesis, and Biological Evaluation of MEK PROTACs

Author Correction: PI3K inhibitors are finally coming of age

Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Development of a robust induced pluripotent stem cell atrial cardiomyocyte differentiation protocol to model atrial arrhythmia

Evolution of PI3Kγ and δ Inhibitors for Inflammatory and Autoimmune Diseases

Multiple Interactions between Cytoplasmic Domains Regulate Slow Deactivation of Kv11.1 Channels

TECRL: connecting sequence to consequence for a new sudden cardiac death gene

The S1 helix critically regulates the finely tuned gating of Kv11.1 channels

Structural and conformational determinants of macrocycle cell permeability

Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels

Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3‑Kinase (PI3K)‑γ Inhibitors

A class of highly selective inhibitors bind to an active state of PI3Kγ

Discovery of AZD8154, a Dual PI3Kγδ Inhibitor for the Treatment of Asthma

Recent advances in understanding and prevention of sudden cardiac death [version 1; peer review: 2 approved]

Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein–Protein Interaction

Protocol-Dependent Differences in IC50 Values Measured in Human Ether-Á-Go-Go-Related Gene Assays Occur in a Predictable Way and Can Be Used to Quantify State Preference of Drug Binding

Design and Synthesis of Soluble and Cell-Permeable PI3Kδ Inhibitors for Long-Acting Inhaled Administration

Spiro-fused Pyrrolidine, Piperidine, and Oxindole Scaffolds from Lactams

Protocol-Dependent Differences in IC 50 Values Measured in Human Ether-Á-Go-Go-Related Gene Assays Occur in a Predictable Way and Can Be Used to Quantify State Preference of Drug Binding

Pore Helices Play a Dynamic Role as Integrators of Domain Motion during Kv11.1 Channel Inactivation Gating

Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2

Segmental differences in upregulated apical potassium channels in mammalian colon during potassium adaptation

Role of the Cytoplasmic N-terminal Cap and Per-Arnt-Sim (PAS) Domain in Trafficking and Stabilization of Kv11.1 Channels

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