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Propofol inhibits carbachol‐induced chloride secretion by directly targeting the basolateral K+ channel in rat ileum epithelium

Neurogastroenterology and motility, 2017-02, Vol.29 (2), p.n/a

2017

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Structure of the voltage-gated K⁺ channel Eag1 reveals an alternative voltage sensing mechanism

Science (American Association for the Advancement of Science), 2016-08, Vol.353 (6300), p.664-669

2016

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Ultrasound modulates ion channel currents

Scientific reports, 2016-04, Vol.6 (1), p.24170-24170, Article 24170

2016

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Cobatoxin 1 from Centruroides noxius scorpion venom: chemical synthesis, three-dimensional structure in solution, pharmacology and docking on K+ channels

Biochemical journal, 2004-01, Vol.377 (Pt 1), p.37-49

2004

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KcsA-Kv1.x chimeras with complete ligand-binding sites provide improved predictivity for screening selective Kv1.x blockers

The Journal of biological chemistry, 2024-04, Vol.300 (4), p.107155-107155, Article 107155

2024

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Potassium channel dysfunction in human neuronal models of Angelman syndrome

Science (American Association for the Advancement of Science), 2019-12, Vol.366 (6472), p.1486-1492

2019

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Cellular elements for seeing in the dark: voltage-dependent conductances in cockroach photoreceptors

BMC neuroscience, 2012-08, Vol.13 (1), p.93-93, Article 93

2012

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Photochromic Blockers of Voltage-Gated Potassium Channels

Angewandte Chemie (International ed.), 2009-01, Vol.48 (48), p.9097-9101

2009

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Structure-activity relationship studies of four novel 4-aminopyridine K + channel blockers

Scientific reports, 2020-01, Vol.10 (1), p.52-52, Article 52

2020

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hERG K(+) channels: structure, function, and clinical significance

Physiological reviews, 2012-07, Vol.92 (3), p.1393-1478

2012

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Structural implications of hERG K+ channel block by a high-affinity minimally structured blocker

The Journal of biological chemistry, 2018-05, Vol.293 (18), p.7040-7057

2018

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Safety and pharmacodynamics of dalazatide, a Kv1.3 channel inhibitor, in the treatment of plaque psoriasis: A randomized phase 1b trial

PloS one, 2017-07, Vol.12 (7), p.e0180762-e0180762

2017

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Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia

Physiological reviews, 2014-04, Vol.94 (2), p.609-653

2014

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Evaluation of Batch Variations in Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes from 2 Major Suppliers

Toxicological sciences, 2017-03, Vol.156 (1), p.25-38

2017

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Chemical and biophysical characterization of novel potassium channel blocker 3-fluoro-5-methylpyridin-4-amine

Scientific reports, 2024-05, Vol.14 (1), p.11105-11105, Article 11105

2024

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Atrial‐like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial‐selective pharmacology

EMBO molecular medicine, 2015-04, Vol.7 (4), p.394-410

2015

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HergSPred: Accurate Classification of hERG Blockers/Nonblockers with Machine-Learning Models

Journal of chemical information and modeling, 2022-04, Vol.62 (8), p.1830-1839

2022

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Expression of the green fluorescent protein in the oligodendrocyte lineage: a transgenic mouse for developmental and physiological studies

Journal of neuroscience research, 2002-11, Vol.70 (4), p.529-545

2002

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Identification of WP1066, an inhibitor of JAK2 and STAT3, as a K V 1.3 potassium channel blocker

British journal of pharmacology, 2021-07, Vol.178 (13), p.2617-2631

2021

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Ion channels as drug targets in central nervous system disorders

Current medicinal chemistry, 2013-04, Vol.20 (10), p.1241-1285

2013

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COVID-19 Drugs Chloroquine and Hydroxychloroquine, but Not Azithromycin and Remdesivir, Block hERG Potassium Channels

The Journal of pharmacology and experimental therapeutics, 2021-05, Vol.377 (2), p.265-272

2021

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Neural KCNQ (Kv7) channels

British journal of pharmacology, 2009-04, Vol.156 (8), p.1185-1195

2009

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A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis

Proceedings of the National Academy of Sciences - PNAS, 2023-01, Vol.120 (2), p.e2211977120-e2211977120

2023

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Effect of nitric oxide-cyclic GMP-K + channel pathway blockers, naloxone and metformin, on the antinociception induced by the diuretic pamabrom

Canadian journal of physiology and pharmacology, 2023-01, Vol.101 (1), p.41-51

2023

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Propofol inhibits carbachol‐induced chloride secretion by directly targeting the basolateral K+ channel in rat ileum epithelium

Structure of the voltage-gated K⁺ channel Eag1 reveals an alternative voltage sensing mechanism

Ultrasound modulates ion channel currents

Cobatoxin 1 from Centruroides noxius scorpion venom: chemical synthesis, three-dimensional structure in solution, pharmacology and docking on K+ channels

KcsA-Kv1.x chimeras with complete ligand-binding sites provide improved predictivity for screening selective Kv1.x blockers

Potassium channel dysfunction in human neuronal models of Angelman syndrome

Direct Pharmacological Targeting of a Mitochondrial Ion Channel Selectively Kills Tumor Cells In Vivo

Cellular elements for seeing in the dark: voltage-dependent conductances in cockroach photoreceptors

Photochromic Blockers of Voltage-Gated Potassium Channels

Structure-activity relationship studies of four novel 4-aminopyridine K + channel blockers

hERG K(+) channels: structure, function, and clinical significance

Structural implications of hERG K+ channel block by a high-affinity minimally structured blocker

Safety and pharmacodynamics of dalazatide, a Kv1.3 channel inhibitor, in the treatment of plaque psoriasis: A randomized phase 1b trial

Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia

Evaluation of Batch Variations in Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes from 2 Major Suppliers

Chemical and biophysical characterization of novel potassium channel blocker 3-fluoro-5-methylpyridin-4-amine

Atrial‐like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial‐selective pharmacology

HergSPred: Accurate Classification of hERG Blockers/Nonblockers with Machine-Learning Models

Expression of the green fluorescent protein in the oligodendrocyte lineage: a transgenic mouse for developmental and physiological studies

Identification of WP1066, an inhibitor of JAK2 and STAT3, as a K V 1.3 potassium channel blocker

Ion channels as drug targets in central nervous system disorders

COVID-19 Drugs Chloroquine and Hydroxychloroquine, but Not Azithromycin and Remdesivir, Block hERG Potassium Channels

Neural KCNQ (Kv7) channels

A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis

Effect of nitric oxide-cyclic GMP-K + channel pathway blockers, naloxone and metformin, on the antinociception induced by the diuretic pamabrom

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