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PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response

Proceedings of the National Academy of Sciences - PNAS, 2021-04, Vol.118 (16), p.1

2021

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PI3Kγ is a molecular switch that controls immune suppression

Nature (London), 2016-11, Vol.539 (7629), p.437-442

2016

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Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors

Science (American Association for the Advancement of Science), 2019-11, Vol.366 (6466), p.714-723

2019

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Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity

Science (American Association for the Advancement of Science), 2021-01, Vol.371 (6527), p.405-410

2021

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A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

Nature (London), 2015-04, Vol.520 (7549), p.683-687

2015

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Luminal B breast cancer: molecular characterization, clinical management, and future perspectives

Journal of clinical oncology, 2014-09, Vol.32 (25), p.2794-2803

2014

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At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy

Nature reviews. Clinical oncology, 2022-07, Vol.19 (7), p.471-485

2022

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regulation of autophagy - unanswered questions

Journal of cell science, 2011-01, Vol.124 (2), p.161-170

2011

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Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice

Gastroenterology (New York, N.Y. 1943), 2015-12, Vol.149 (7), p.1884-1895.e4

2015

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The lysosome as a command-and-control center for cellular metabolism

The Journal of cell biology, 2016-09, Vol.214 (6), p.653-664

2016

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Altered miR-29 Expression in Type 2 Diabetes Influences Glucose and Lipid Metabolism in Skeletal Muscle

Diabetes (New York, N.Y.), 2017-07, Vol.66 (7), p.1807-1818

2017

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The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12), p.2269-2280

2022

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Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial

Journal of clinical oncology, 2019-03, Vol.37 (9), p.741-750

2019

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Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma

The Journal of biological chemistry, 2015-07, Vol.290 (28), p.17495-17504

2015

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The Hippo pathway integrates PI3K-Akt signals with mechanical and polarity cues to control tissue growth

PLoS biology, 2019-10, Vol.17 (10), p.e3000509-e3000509

2019

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The PI3K/AKT pathway in the pathogenesis of prostate cancer

Frontiers in bioscience (Landmark. Print), 2016-06, Vol.21 (5), p.1084

2016

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Cracking the context-specific PI3K signaling code

Science signaling, 2020-01, Vol.13 (613)

2020

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TGF-β promotes PI3K-AKT signaling and prostate cancer cell migration through the TRAF6-mediated ubiquitylation of p85α

Science signaling, 2017-07, Vol.10 (486)

2017

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Molecular determinants of PI3Kγ-mediated activation downstream of G-protein–coupled receptors (GPCRs)

Proceedings of the National Academy of Sciences - PNAS, 2013-11, Vol.110 (47), p.18862-18867

2013

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Insulin growth factor signaling is regulated by microRNA-486, an underexpressed microRNA in lung cancer

Proceedings of the National Academy of Sciences - PNAS, 2013-09, Vol.110 (37), p.15043-15048

2013

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Cancer-associated mutations in the p85α N-terminal SH2 domain activate a spectrum of receptor tyrosine kinases

Proceedings of the National Academy of Sciences - PNAS, 2021-09, Vol.118 (37)

2021

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Ultrastructural analysis of autophagosome organization using mammalian autophagy-deficient cells

Journal of cell science, 2014-09, Vol.127 (Pt 18), p.4089-4102

2014

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Increased Serotonin Signaling Contributes to the Warburg Effect in Pancreatic Tumor Cells under Metabolic Stress and Promotes Growth of Pancreatic Tumors in Mice

Gastroenterology (New York, N.Y. 1943), 2017-07, Vol.153 (1), p.277-291.e19

2017

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PIK3CA C-terminal frameshift mutations are novel oncogenic events that sensitize tumors to PI3K-α inhibition

Proceedings of the National Academy of Sciences - PNAS, 2020-09, Vol.117 (39), p.24427-24433

2020

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PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response

PI3Kγ is a molecular switch that controls immune suppression

Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors

Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

Luminal B breast cancer: molecular characterization, clinical management, and future perspectives

At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy

regulation of autophagy - unanswered questions

Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice

The lysosome as a command-and-control center for cellular metabolism

Altered miR-29 Expression in Type 2 Diabetes Influences Glucose and Lipid Metabolism in Skeletal Muscle

PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity

The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation

Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial

Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma

The Hippo pathway integrates PI3K-Akt signals with mechanical and polarity cues to control tissue growth

The PI3K/AKT pathway in the pathogenesis of prostate cancer

Cracking the context-specific PI3K signaling code

TGF-β promotes PI3K-AKT signaling and prostate cancer cell migration through the TRAF6-mediated ubiquitylation of p85α

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein–coupled receptors (GPCRs)

Insulin growth factor signaling is regulated by microRNA-486, an underexpressed microRNA in lung cancer

Cancer-associated mutations in the p85α N-terminal SH2 domain activate a spectrum of receptor tyrosine kinases

Ultrastructural analysis of autophagosome organization using mammalian autophagy-deficient cells

Increased Serotonin Signaling Contributes to the Warburg Effect in Pancreatic Tumor Cells under Metabolic Stress and Promotes Growth of Pancreatic Tumors in Mice

PIK3CA C-terminal frameshift mutations are novel oncogenic events that sensitize tumors to PI3K-α inhibition

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