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A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing

Cell reports (Cambridge), 2018-02, Vol.22 (9), p.2227-2235

2018

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The phosphoinositide-3 kinase (PI3K)-δ,γ inhibitor, duvelisib shows preclinical synergy with multiple targeted therapies in hematologic malignancies

PloS one, 2018-08, Vol.13 (8), p.e0200725

2018

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Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)‑γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate

ACS medicinal chemistry letters, 2016-09, Vol.7 (9), p.862-867

2016

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Discovery of a Potent and Orally Active Hedgehog Pathway Antagonist (IPI-926)

Journal of medicinal chemistry, 2009-07, Vol.52 (14), p.4400-4418

2009

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Development of 17-Allylamino-17-Demethoxygeldanamycin Hydroquinone Hydrochloride (IPI-504), an Anti-Cancer Agent Directed against Hsp90

Proceedings of the National Academy of Sciences - PNAS, 2006-11, Vol.103 (46), p.17408-17413

2006

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The antiproliferative activity of the heat shock protein 90 inhibitor IPI-504 is not dependent on NAD(P)H:quinone oxidoreductase 1 activity in vivo

Molecular cancer therapeutics, 2009-12, Vol.8 (12), p.3369-3378

2009

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Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells

Nature (London), 2016-11, Vol.539 (7629), p.443-447

2016

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PI3Kγ is a molecular switch that controls immune suppression

Nature (London), 2016-11, Vol.539 (7629), p.437-442

2016

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Temperature and its impact on predation risk within aquatic ecosystems

Canadian journal of fisheries and aquatic sciences, 2016-06, Vol.73 (6), p.869-876

2016

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In shallow water ecosytems the abiotic environment is more important than prey abundance for foraging terns

Environmental biology of fishes, 2018-03, Vol.101 (3), p.355-362

2018

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The phosphoinositide-3 kinase -[delta],[gamma] inhibitor, duvelisib shows preclinical synergy with multiple targeted therapies in hematologic malignancies

PloS one, 2018-08, Vol.13 (8)

2018

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The phosphoinositide-3 kinase

PloS one, 2018-08, Vol.13 (8)

2018

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Abstract 376: Combination of duvelisib with either ibrutinib or dexamethasone prevents mTOR-dependent feedback in aggressive B-cell lymphoma cell lines

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.376-376

2016

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Abstract 554: Checkpoint blockade therapy is improved by altering the immune suppressive microenvironment with IPI-549, a potent and selective inhibitor of PI3K-gamma, in preclinical models

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.554-554

2016

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Erratum: Corrigendum: PI3Kγ is a molecular switch that controls immune suppression

Nature (London), 2016-12, Vol.542 (7639), p.124-124

2016

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High throughput in vitro combination sensitivity screen in hematologic malignancies with the phosphoinositide-3 kinase (PI3K)-δ,γ inhibitor, duvelisib

Journal of clinical oncology, 2015-05, Vol.33 (15_suppl), p.8559-8559

2015

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Abstract A192: The potent and selective phosphoinositide-3-kinase-γ inhibitor, IPI-549, inhibits tumor growth in murine syngeneic solid tumor models through alterations in the immune suppressive microenvironment

Molecular cancer therapeutics, 2015-12, Vol.14 (12_Supplement_2), p.A192-A192

2015

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Abstract B032: The PI3K-γ inhibitor, IPI-549, increases antitumor immunity by targeting tumor-associated myeloid cells and remodeling the immune-suppressive tumor microenvironment

Cancer immunology research, 2016-11, Vol.4 (11_Supplement), p.B032-B032

2016

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The abiotic environment and predator-prey interactions: direct and indirect effects within aquatic environments with a specific look at temperature

Pink, Melissa

2011

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Abstract B029: The potent and selective phosphoinositide-3-kinase-gamma inhibitor, IPI-549, inhibits tumor growth in murine syngeneic solid tumor models through alterations in the immune suppressive microenvironment

Cancer immunology research, 2016-01, Vol.4 (1_Supplement), p.B029-B029

2016

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Use of Underwater Visual Distance Sampling for Estimating Habitat‐Specific Population Density

North American journal of fisheries management, 2007-02, Vol.27 (1), p.246-255

2007

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Distance sampling methods: Implementation in detecting responses of cyprinids to piscivore introduction

Pink, Melissa

2006

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IPI-504: A Novel hsp90 Inhibitor with In Vitro and In Vivo Anti-Tumor Activity

Blood, 2004-11, Vol.104 (11), p.2403-2403

2004

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Central analgesic actions of loperamide following transient permeation of the blood brain barrier with Cereport™ (RMP-7)

Brain research, 1998-08, Vol.801 (1), p.259-266

1998

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A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing

The phosphoinositide-3 kinase (PI3K)-δ,γ inhibitor, duvelisib shows preclinical synergy with multiple targeted therapies in hematologic malignancies

Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)‑γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate

Discovery of a Potent and Orally Active Hedgehog Pathway Antagonist (IPI-926)

Development of 17-Allylamino-17-Demethoxygeldanamycin Hydroquinone Hydrochloride (IPI-504), an Anti-Cancer Agent Directed against Hsp90

The antiproliferative activity of the heat shock protein 90 inhibitor IPI-504 is not dependent on NAD(P)H:quinone oxidoreductase 1 activity in vivo

Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells

PI3Kγ is a molecular switch that controls immune suppression

Temperature and its impact on predation risk within aquatic ecosystems

In shallow water ecosytems the abiotic environment is more important than prey abundance for foraging terns

The phosphoinositide-3 kinase -[delta],[gamma] inhibitor, duvelisib shows preclinical synergy with multiple targeted therapies in hematologic malignancies

The phosphoinositide-3 kinase

Abstract 376: Combination of duvelisib with either ibrutinib or dexamethasone prevents mTOR-dependent feedback in aggressive B-cell lymphoma cell lines

Abstract 554: Checkpoint blockade therapy is improved by altering the immune suppressive microenvironment with IPI-549, a potent and selective inhibitor of PI3K-gamma, in preclinical models

Erratum: Corrigendum: PI3Kγ is a molecular switch that controls immune suppression

High throughput in vitro combination sensitivity screen in hematologic malignancies with the phosphoinositide-3 kinase (PI3K)-δ,γ inhibitor, duvelisib

Abstract A192: The potent and selective phosphoinositide-3-kinase-γ inhibitor, IPI-549, inhibits tumor growth in murine syngeneic solid tumor models through alterations in the immune suppressive microenvironment

Abstract B032: The PI3K-γ inhibitor, IPI-549, increases antitumor immunity by targeting tumor-associated myeloid cells and remodeling the immune-suppressive tumor microenvironment

The abiotic environment and predator-prey interactions: direct and indirect effects within aquatic environments with a specific look at temperature

Abstract B029: The potent and selective phosphoinositide-3-kinase-gamma inhibitor, IPI-549, inhibits tumor growth in murine syngeneic solid tumor models through alterations in the immune suppressive microenvironment

Use of Underwater Visual Distance Sampling for Estimating Habitat‐Specific Population Density

PI3K-δ and PI3K-γ Inhibition by IPI-145 Abrogates Immune Responses and Suppresses Activity in Autoimmune and Inflammatory Disease Models

Distance sampling methods: Implementation in detecting responses of cyprinids to piscivore introduction

IPI-504: A Novel hsp90 Inhibitor with In Vitro and In Vivo Anti-Tumor Activity

Central analgesic actions of loperamide following transient permeation of the blood brain barrier with Cereport™ (RMP-7)

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