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Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms

Structure (London), 2014-08, Vol.22 (8), p.1161-1172

2014

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Discovery and Preclinical Characterization of 6‑Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]‑1H‑indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy

Journal of medicinal chemistry, 2016-09, Vol.59 (17), p.8068-8081

2016

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Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators

Biochemical journal, 2016-03, Vol.473 (5), p.581-592

2016

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Glycomimetic Ligands for the Human Asialoglycoprotein Receptor

Journal of the American Chemical Society, 2012-02, Vol.134 (4), p.1978-1981

2012

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Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK)

Journal of medicinal chemistry, 2017-09, Vol.60 (18), p.7835-7849

2017

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NMR spectroscopy: the swiss army knife of drug discovery

Journal of biomolecular NMR, 2020-11, Vol.74 (10-11), p.509-519

2020

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A Thermodynamic Scale for the .beta.-Sheet Forming Tendencies of the Amino Acids

Biochemistry (Easton), 1994-05, Vol.33 (18), p.5510-5517

1994

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PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease

Journal of medicinal chemistry, 2021-01, Vol.64 (1), p.326-342

2021

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An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes

Structure (London), 2018-04, Vol.26 (4), p.533-544.e3

2018

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Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide

Scientific reports, 2016-05, Vol.6 (1), p.26071, Article 26071

2016

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Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists

Scientific reports, 2016-08, Vol.6 (1), p.30859-30859, Article 30859

2016

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Short Hydrophobic Peptides with Cyclic Constraints Are Potent Glucagon-like Peptide‑1 Receptor (GLP-1R) Agonists

Journal of medicinal chemistry, 2015-05, Vol.58 (9), p.4080-4085

2015

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Spirocyclic Sulfamides as β‑Secretase 1 (BACE-1) Inhibitors for the Treatment of Alzheimer’s Disease: Utilization of Structure Based Drug Design, WaterMap, and CNS Penetration Studies To Identify Centrally Efficacious Inhibitors

Journal of medicinal chemistry, 2012-11, Vol.55 (21), p.9224-9239

2012

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Discovery and Optimization of a Novel Spiropyrrolidine Inhibitor of β-Secretase (BACE1) through Fragment-Based Drug Design

Journal of medicinal chemistry, 2012-11, Vol.55 (21), p.9069-9088

2012

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Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5′-Adenosine Monophosphate-Activated Protein Kinase (AMPK)

Journal of medicinal chemistry, 2018-03, Vol.61 (6), p.2372-2383

2018

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Intramolecular Ring-Opening Decomposition of Aryl Azetidines

ACS medicinal chemistry letters, 2021-10, Vol.12 (10), p.1585-1588

2021

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Biophysical Interactions of Direct AMPK Activators

Methods in molecular biology (Clifton, N.J.), 2018-01, Vol.1732, p.29

2018

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Synthesis of Macrocyclic, Potential Protease Inhibitors Using a Generic Scaffold

Journal of organic chemistry, 2002-07, Vol.67 (14), p.4882-4892

2002

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Design of a multi-purpose fragment screening library using molecular complexity and orthogonal diversity metrics

Journal of computer-aided molecular design, 2011-07, Vol.25 (7), p.621-636

2011

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Design and Synthesis of Truncated EGF-A Peptides that Restore LDL-R Recycling in the Presence of PCSK9 In Vitro

Chemistry & biology, 2014-02, Vol.21 (2), p.284-294

2014

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Molecular features crucial to the activity of pyrimidine benzamide-based thrombopoietin receptor agonists

Bioorganic & medicinal chemistry, 2008-05, Vol.18 (9), p.3000-3006

2008

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Cyclization of N-Terminal S-Carbamoylmethylcysteine Causing Loss of 17 Da from Peptides and Extra Peaks in Peptide Maps

Journal of proteome research, 2002-03, Vol.1 (2), p.181-187

2002

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Allosteric inhibition of fructose-1,6-bisphosphatase by anilinoquinazolines

Bioorganic & medicinal chemistry letters, 2001-01, Vol.11 (1), p.17-21

2001

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The CD58 (LFA-3) Binding Site is a Localized and Highly Charged Surface Area on the AGFCC'C'' Face of the Human CD2 Adhesion Domain

Proceedings of the National Academy of Sciences - PNAS, 1993-12, Vol.90 (24), p.11613-11617

1993

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Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms

Discovery and Preclinical Characterization of 6‑Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]‑1H‑indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy

Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators

Glycomimetic Ligands for the Human Asialoglycoprotein Receptor

Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK)

NMR spectroscopy: the swiss army knife of drug discovery

A Thermodynamic Scale for the .beta.-Sheet Forming Tendencies of the Amino Acids

PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease

An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes

Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide

Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists

Short Hydrophobic Peptides with Cyclic Constraints Are Potent Glucagon-like Peptide‑1 Receptor (GLP-1R) Agonists

Spirocyclic Sulfamides as β‑Secretase 1 (BACE-1) Inhibitors for the Treatment of Alzheimer’s Disease: Utilization of Structure Based Drug Design, WaterMap, and CNS Penetration Studies To Identify Centrally Efficacious Inhibitors

Discovery and Optimization of a Novel Spiropyrrolidine Inhibitor of β-Secretase (BACE1) through Fragment-Based Drug Design

Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5′-Adenosine Monophosphate-Activated Protein Kinase (AMPK)

Intramolecular Ring-Opening Decomposition of Aryl Azetidines

Aminopyrazole Carboxamide Bruton’s Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning

Biophysical Interactions of Direct AMPK Activators

Synthesis of Macrocyclic, Potential Protease Inhibitors Using a Generic Scaffold

Design of a multi-purpose fragment screening library using molecular complexity and orthogonal diversity metrics

Design and Synthesis of Truncated EGF-A Peptides that Restore LDL-R Recycling in the Presence of PCSK9 In Vitro

Molecular features crucial to the activity of pyrimidine benzamide-based thrombopoietin receptor agonists

Cyclization of N-Terminal S-Carbamoylmethylcysteine Causing Loss of 17 Da from Peptides and Extra Peaks in Peptide Maps

Allosteric inhibition of fructose-1,6-bisphosphatase by anilinoquinazolines

The CD58 (LFA-3) Binding Site is a Localized and Highly Charged Surface Area on the AGFCC'C'' Face of the Human CD2 Adhesion Domain

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