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Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators

Biochemical journal, 2016-03, Vol.473 (5), p.581-592

2016

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Discovery and Preclinical Characterization of 6‑Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]‑1H‑indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy

Journal of medicinal chemistry, 2016-09, Vol.59 (17), p.8068-8081

2016

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Identification and optimization of indolo[2,3-c]quinoline inhibitors of IRAK4

Bioorganic & medicinal chemistry letters, 2014-05, Vol.24 (9), p.2066-2072

2014

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Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (9), p.2400-2403

2009

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Characterization of 11 commercial pyrethroids on the functional attributes of rat brain synaptosomes

Pesticide biochemistry and physiology, 2008-10, Vol.92 (2), p.61-69

2008

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Binary mixtures of pyrethroids produce differential effects on Ca2+ influx and glutamate release at isolated presynaptic nerve terminals from rat brain

Pesticide biochemistry and physiology, 2011-02, Vol.99 (2), p.131-139

2011

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Action of cismethrin and deltamethrin on functional attributes of isolated presynaptic nerve terminals from rat brain

Pesticide biochemistry and physiology, 2007-02, Vol.87 (2), p.172-181

2007

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Esterase-mediated malathion resistance in the human head louse, Pediculus capitis (Anoplura: Pediculidae)

Pesticide biochemistry and physiology, 2006-05, Vol.85 (1), p.28-37

2006

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Discovery of Clinical Candidate 1‑{[(2S,3S,4S)‑3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin‑1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Journal of medicinal chemistry, 2017-07, Vol.60 (13), p.5521-5542

2017

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Mutation of threonine 422 to glutamic acid mimics the phosphorylation state and alters the action of deltamethrin on Cav2.2

Pesticide biochemistry and physiology, 2007-07, Vol.88 (3), p.312-320

2007

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Association of Polymorphisms of the IL-17A and IL-17F Genes with Increased Risk of Hypertension and Obesity in Mexican Patients with COVID-19

Journal of interferon & cytokine research, 2024-02, Vol.44 (2), p.60

2024

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Abstract WP236: Trends in Antithrombotic Therapy Use and Clinical Outcome in Acute Ischemic Stroke and Atrial Fibrillation in a Hispanic Population in the Era of Direct Oral Anticoagulants

Stroke (1970), 2019-02, Vol.50 (Suppl_1)

2019

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Rational approach to highly potent and selective apoptosis signal-regulating kinase 1 (ASK1) inhibitors

European journal of medicinal chemistry, 2018-02, Vol.145, p.606-621

2018

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Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H -indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy

Journal of medicinal chemistry, 2016-09, Vol.59 (17), p.8068-8081

2016

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Escherichia coli expression, purification and characterization of functional full-length recombinant α2β2γ3 heterotrimeric complex of human AMP-activated protein kinase

Protein expression and purification, 2010-10, Vol.73 (2), p.189-197

2010

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Binary mixtures of pyrethroids produce differential effects on Ca 2+ influx and glutamate release at isolated presynaptic nerve terminals from rat brain

Pesticide biochemistry and physiology, 2011, Vol.99 (2), p.131-139

2011

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Escherichia coli expression, purification and characterization of functional full-length recombinant a2b2g3 heterotrimeric complex of human AMP-activated protein kinase

Protein expression and purification, 2010-10, Vol.73 (2), p.189-197

2010

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New directions in evaluation: A school district perspective

Theory into practice, 1991-01, Vol.30 (1), p.46-51

Frisbie, Richard D.

1991

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Escherichia coli expression, purification and characterization of functional full-length recombinant alpha2beta2gamma3 heterotrimeric complex of human AMP-activated protein kinase

Protein expression and purification, 2010-10, Vol.73 (2), p.189-197

2010

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Historical dictionary of Lesotho

2004

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Evaluation of Intra-Articular Mesenchymal Stem Cells to Augment Healing of Microfractured Chondral Defects

Arthroscopy, 2011-11, Vol.27 (11), p.1552-1561

2011

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Manganese levels in infant formula and young child nutritional beverages in the United States and France: Comparison to breast milk and regulations

PloS one, 2019-11, Vol.14 (11), p.e0223636-e0223636

2019

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Many challenges seen in solving the manpower jigsaw puzzle

World oil, 2007-04, p.1

2007

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Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network

Science (American Association for the Advancement of Science), 2017-04, Vol.356 (6336), p.395-395

2017

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Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators

Discovery and Preclinical Characterization of 6‑Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]‑1H‑indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy

Identification and optimization of indolo[2,3-c]quinoline inhibitors of IRAK4

Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms

Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists

Characterization of 11 commercial pyrethroids on the functional attributes of rat brain synaptosomes

Binary mixtures of pyrethroids produce differential effects on Ca2+ influx and glutamate release at isolated presynaptic nerve terminals from rat brain

Action of cismethrin and deltamethrin on functional attributes of isolated presynaptic nerve terminals from rat brain

Esterase-mediated malathion resistance in the human head louse, Pediculus capitis (Anoplura: Pediculidae)

Discovery of Clinical Candidate 1‑{[(2S,3S,4S)‑3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin‑1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Mutation of threonine 422 to glutamic acid mimics the phosphorylation state and alters the action of deltamethrin on Cav2.2

Association of Polymorphisms of the IL-17A and IL-17F Genes with Increased Risk of Hypertension and Obesity in Mexican Patients with COVID-19

Abstract WP236: Trends in Antithrombotic Therapy Use and Clinical Outcome in Acute Ischemic Stroke and Atrial Fibrillation in a Hispanic Population in the Era of Direct Oral Anticoagulants

Rational approach to highly potent and selective apoptosis signal-regulating kinase 1 (ASK1) inhibitors

Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H -indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy

Escherichia coli expression, purification and characterization of functional full-length recombinant α2β2γ3 heterotrimeric complex of human AMP-activated protein kinase

Binary mixtures of pyrethroids produce differential effects on Ca 2+ influx and glutamate release at isolated presynaptic nerve terminals from rat brain

Escherichia coli expression, purification and characterization of functional full-length recombinant a2b2g3 heterotrimeric complex of human AMP-activated protein kinase

New directions in evaluation: A school district perspective

Escherichia coli expression, purification and characterization of functional full-length recombinant alpha2beta2gamma3 heterotrimeric complex of human AMP-activated protein kinase

Historical dictionary of Lesotho

Evaluation of Intra-Articular Mesenchymal Stem Cells to Augment Healing of Microfractured Chondral Defects

Manganese levels in infant formula and young child nutritional beverages in the United States and France: Comparison to breast milk and regulations

Many challenges seen in solving the manpower jigsaw puzzle

Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network

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