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Fragment‐based screening targeting an open form of the SARS‐CoV‐2 main protease binding pocket

Acta crystallographica. Section D, Biological crystallography., 2024-02, Vol.80 (2), p.123-136

2024

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The crystallization additive hexatungstotellurate promotes the crystallization of the HSP70 nucleotide binding domain into two different crystal forms

PloS one, 2018-06, Vol.13 (6), p.e0199639-e0199639

2018

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Small-molecule factor B inhibitor for the treatment of complement-mediated diseases

Proceedings of the National Academy of Sciences - PNAS, 2019-04, Vol.116 (16), p.7926-7931

2019

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Inverse agonist efficacy of selatogrel blunts constitutive P2Y12 receptor signaling by inducing the inactive receptor conformation

Biochemical pharmacology, 2022-12, Vol.206, p.115291-115291, Article 115291

2022

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Small-molecule factor D inhibitors targeting the alternative complement pathway

Nature chemical biology, 2016-12, Vol.12 (12), p.1105

2016

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Insights into the Regulatory Mechanism for Caspase-8 Activation

Molecular cell, 2003-02, Vol.11 (2), p.543-549

2003

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Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors

Journal of medicinal chemistry, 2017-03, Vol.60 (5), p.1946-1958

2017

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Structure-based design and optimization of potent inhibitors of the adenoviral protease

Bioorganic & medicinal chemistry letters, 2015-02, Vol.25 (3), p.438-443

2015

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Modified microbatch and seeding in protein crystallization experiments

Journal of synchrotron radiation, 2004-01, Vol.11 (1), p.24-26

2004

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The 1.15 Å Crystal Structure of the Staphylococcus aureus Methionyl-aminopeptidase and Complexes with Triazole Based Inhibitors

Journal of molecular biology, 2003-09, Vol.332 (1), p.13-21

2003

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Using natural seeding material to generate nucleation in protein crystallization experiments

Acta crystallographica. Section D, Biological crystallography., 2003-07, Vol.59 (7), p.1343-1346

2003

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The advantages of using a modified microbatch method for rapid screening of protein crystallization conditions

Acta crystallographica. Section D, Biological crystallography., 2003-02, Vol.59 (2), p.396-399

2003

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Discovery of Novel Inhibitors of LpxC Displaying Potent in Vitro Activity against Gram-Negative Bacteria

Journal of medicinal chemistry, 2020-01, Vol.63 (1), p.66-87

2020

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Discovery of 4-((2 S ,4 S )-4-Ethoxy-1-((5-methoxy-7-methyl-1 H -indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases

Journal of medicinal chemistry, 2020-06, Vol.63 (11), p.5697-5722

2020

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Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo

Journal of medicinal chemistry, 2017-07, Vol.60 (13), p.5717-5735

2017

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Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway

Journal of medicinal chemistry, 2019-05, Vol.62 (9), p.4656-4668

2019

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The Crystal Structure of E. coli 1-Deoxy- d-xylulose-5-phosphate Reductoisomerase in a Ternary Complex with the Antimalarial Compound Fosmidomycin and NADPH Reveals a Tight-binding Closed Enzyme Conformation

Journal of molecular biology, 2005-01, Vol.345 (1), p.115-127

2005

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Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D

ACS medicinal chemistry letters, 2018-05, Vol.9 (5), p.490-495

2018

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Discovery and Structure-Based Optimization of Adenain Inhibitors

ACS medicinal chemistry letters, 2014-08, Vol.5 (8), p.937-941

2014

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High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[({2-[(5-iodopyridin-2-yl)amino]-ethyl}amino)-acetyl]-2-cyano-(S)-pyrrolidine

Acta crystallographica. Section D, Biological crystallography., 2003-07, Vol.59 (7), p.1206-1212

2003

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Practical aspects of using the microbatch method in screening conditions for protein crystallization

Methods (San Diego, Calif.), 2004-11, Vol.34 (3), p.323-328

2004

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A simple and rapid method for mounting protein crystals at room temperature

Journal of applied crystallography, 2003-02, Vol.36 (1), p.165-166

2003

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Crystal structures of Staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate

Journal of medicinal chemistry, 2004-03, Vol.47 (6), p.1325-1328

2004

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The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation

Journal of molecular biology, 2005-01, Vol.345 (1), p.115-127

2005

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Crystal Structures of Staphylococcus aureus Methionine Aminopeptidase Complexed with Keto Heterocycle and Aminoketone Inhibitors Reveal the Formation of a Tetrahedral Intermediate

Journal of medicinal chemistry, 2005-01, Vol.48 (1), p.336-336

2005

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Fragment‐based screening targeting an open form of the SARS‐CoV‐2 main protease binding pocket

The crystallization additive hexatungstotellurate promotes the crystallization of the HSP70 nucleotide binding domain into two different crystal forms

Small-molecule factor B inhibitor for the treatment of complement-mediated diseases

Inverse agonist efficacy of selatogrel blunts constitutive P2Y12 receptor signaling by inducing the inactive receptor conformation

Small-molecule factor D inhibitors targeting the alternative complement pathway

Insights into the Regulatory Mechanism for Caspase-8 Activation

Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors

Structure-based design and optimization of potent inhibitors of the adenoviral protease

Modified microbatch and seeding in protein crystallization experiments

The 1.15 Å Crystal Structure of the Staphylococcus aureus Methionyl-aminopeptidase and Complexes with Triazole Based Inhibitors

Using natural seeding material to generate nucleation in protein crystallization experiments

The advantages of using a modified microbatch method for rapid screening of protein crystallization conditions

Discovery of Novel Inhibitors of LpxC Displaying Potent in Vitro Activity against Gram-Negative Bacteria

Discovery of 4-((2 S ,4 S )-4-Ethoxy-1-((5-methoxy-7-methyl-1 H -indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases

Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo

Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway

The Crystal Structure of E. coli 1-Deoxy- d-xylulose-5-phosphate Reductoisomerase in a Ternary Complex with the Antimalarial Compound Fosmidomycin and NADPH Reveals a Tight-binding Closed Enzyme Conformation

Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D

Discovery and Structure-Based Optimization of Adenain Inhibitors

High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[({2-[(5-iodopyridin-2-yl)amino]-ethyl}amino)-acetyl]-2-cyano-(S)-pyrrolidine

Practical aspects of using the microbatch method in screening conditions for protein crystallization

A simple and rapid method for mounting protein crystals at room temperature

Crystal structures of Staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate

The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation

Crystal Structures of Staphylococcus aureus Methionine Aminopeptidase Complexed with Keto Heterocycle and Aminoketone Inhibitors Reveal the Formation of a Tetrahedral Intermediate

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