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Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex

Nature chemical biology, 2020-01, Vol.16 (1), p.15-23

2020

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Medicinal Chemistry Profiling of Monocyclic 1,2‐Azaborines

ChemMedChem, 2017-03, Vol.12 (5), p.358-361

2017

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Author Correction: Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex

Nature chemical biology, 2020-03, Vol.16 (3), p.361-361

2020

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Small-molecule factor B inhibitor for the treatment of complement-mediated diseases

Proceedings of the National Academy of Sciences - PNAS, 2019-04, Vol.116 (16), p.7926-7931

2019

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Comprehensive Structural Studies of 2′,3′-Difluorinated Nucleosides: Comparison of Theory, Solution, and Solid State

Journal of the American Chemical Society, 2008-07, Vol.130 (28), p.9048-9057

2008

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Structure of neprilysin in complex with the active metabolite of sacubitril

Scientific reports, 2016-06, Vol.6 (1), p.27909-27909, Article 27909

2016

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Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders

Journal of medicinal chemistry, 2020-02, Vol.63 (3), p.1068-1083

2020

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Discovery of 4-((2 S ,4 S )-4-Ethoxy-1-((5-methoxy-7-methyl-1 H -indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases

Journal of medicinal chemistry, 2020-06, Vol.63 (11), p.5697-5722

2020

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Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach

Journal of medicinal chemistry, 2020-08, Vol.63 (15), p.8088-8113

2020

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Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway

Journal of medicinal chemistry, 2019-05, Vol.62 (9), p.4656-4668

2019

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Design and Rationale of the APPELHUS Phase 3 Open-Label Study of Factor B Inhibitor Iptacopan for Atypical Hemolytic Uremic Syndrome

Kidney international reports, 2023-07, Vol.8 (7), p.1332-1341

2023

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PDB Ligand Conformational Energies Calculated Quantum-Mechanically

Journal of chemical information and modeling, 2012-03, Vol.52 (3), p.739-756

2012

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Three-dimensional quantitative structure–activity relationship (3D-QSAR) of 3-aryloxazolidin-2-one antibacterials

Bioorganic & medicinal chemistry, 2001-12, Vol.9 (12), p.3153-3160

2001

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Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors

ACS medicinal chemistry letters, 2020-02, Vol.11 (2), p.188-194

2020

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Metal-dependent inhibition of HIV-1 integrase by beta-diketo acids and resistance of the soluble double-mutant (F185K/C280S)

Molecular pharmacology, 2003-09, Vol.64 (3), p.600-609

2003

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Virtual screening application of a model of full-length HIV-1 integrase complexed with viral DNA

Bioorganic & medicinal chemistry letters, 2007-10, Vol.17 (19), p.5361-5365

2007

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Noticing the unnoticed: bridging structural data and drug design

Future medicinal chemistry, 2012-10, Vol.4 (15), p.1869-1871

2012

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Application of azide–alkyne cycloaddition ‘click chemistry’ for the synthesis of Grb2 SH2 domain-binding macrocycles

Bioorganic & medicinal chemistry letters, 2006-10, Vol.16 (20), p.5265-5269

2006

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Model of full-length HIV-1 integrase complexed with viral DNA as template for anti-HIV drug design

Journal of computer-aided molecular design, 2004-12, Vol.18 (12), p.739-760

2004

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Utilization of a Common Pathway for the Synthesis of High Affinity Macrocyclic Grb2 SH2 Domain-Binding Peptide Mimetics That Differ in the Configuration at One Ring Junction

Chemistry & biodiversity, 2005-04, Vol.2 (4), p.447-456

2005

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Metal-Dependent Inhibition of HIV-1 Integrase

Journal of medicinal chemistry, 2002-12, Vol.45 (26), p.5661-5670

2002

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Azido-Containing aryl β-Diketo acid HIV-1 integrase inhibitors

Bioorganic & medicinal chemistry letters, 2003-03, Vol.13 (6), p.1215-1219

2003

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A feature based pharmacophore for Candida albicans MyristoylCoA: protein N-myristoyltransferase inhibitors

European journal of medicinal chemistry, 2001-02, Vol.36 (2), p.147-163

2001

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Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex

Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers

Medicinal Chemistry Profiling of Monocyclic 1,2‐Azaborines

Author Correction: Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex

Small-molecule factor B inhibitor for the treatment of complement-mediated diseases

Comprehensive Structural Studies of 2′,3′-Difluorinated Nucleosides: Comparison of Theory, Solution, and Solid State

Structure of neprilysin in complex with the active metabolite of sacubitril

Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders

Discovery of 4-((2 S ,4 S )-4-Ethoxy-1-((5-methoxy-7-methyl-1 H -indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases

Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes

Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach

Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway

Design and Rationale of the APPELHUS Phase 3 Open-Label Study of Factor B Inhibitor Iptacopan for Atypical Hemolytic Uremic Syndrome

PDB Ligand Conformational Energies Calculated Quantum-Mechanically

Three-dimensional quantitative structure–activity relationship (3D-QSAR) of 3-aryloxazolidin-2-one antibacterials

Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors

Metal-dependent inhibition of HIV-1 integrase by beta-diketo acids and resistance of the soluble double-mutant (F185K/C280S)

Virtual screening application of a model of full-length HIV-1 integrase complexed with viral DNA

Noticing the unnoticed: bridging structural data and drug design

Application of azide–alkyne cycloaddition ‘click chemistry’ for the synthesis of Grb2 SH2 domain-binding macrocycles

Model of full-length HIV-1 integrase complexed with viral DNA as template for anti-HIV drug design

Utilization of a Common Pathway for the Synthesis of High Affinity Macrocyclic Grb2 SH2 Domain-Binding Peptide Mimetics That Differ in the Configuration at One Ring Junction

Metal-Dependent Inhibition of HIV-1 Integrase

Azido-Containing aryl β-Diketo acid HIV-1 integrase inhibitors

A feature based pharmacophore for Candida albicans MyristoylCoA: protein N-myristoyltransferase inhibitors

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