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A proteogenomic signature of age-related macular degeneration in blood

Nature communications, 2022-06, Vol.13 (1), p.3401-3401, Article 3401

2022

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Small-molecule factor B inhibitor for the treatment of complement-mediated diseases

Proceedings of the National Academy of Sciences - PNAS, 2019-04, Vol.116 (16), p.7926-7931

2019

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Differential and Altered Spatial Distribution of Complement Expression in Age-Related Macular Degeneration

Investigative ophthalmology & visual science, 2021-06, Vol.62 (7), p.26-26

2021

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Temporal Regulation of RNA Polymerase II by Srb10 and Kin28 Cyclin-Dependent Kinases

Molecular cell, 1998-07, Vol.2 (1), p.43-53

1998

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Lack of involvement of CEP adducts in TLR activation and in angiogenesis

PloS one, 2014-10, Vol.9 (10), p.e111472-e111472

2014

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Small-molecule factor D inhibitors targeting the alternative complement pathway

Nature chemical biology, 2016-12, Vol.12 (12), p.1105

2016

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Complement factor B is critical for sub-RPE deposit accumulation in a model of Doyne honeycomb retinal dystrophy with features of age-related macular degeneration

Human molecular genetics, 2023-01, Vol.32 (2), p.204-217

2023

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Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models

Investigative ophthalmology & visual science, 2018-02, Vol.59 (2), p.940-951

2018

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Discovery of 4-((2 S ,4 S )-4-Ethoxy-1-((5-methoxy-7-methyl-1 H -indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases

Journal of medicinal chemistry, 2020-06, Vol.63 (11), p.5697-5722

2020

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Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo

Journal of medicinal chemistry, 2017-07, Vol.60 (13), p.5717-5735

2017

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Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway

Journal of medicinal chemistry, 2019-05, Vol.62 (9), p.4656-4668

2019

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A kinase-cyclin pair in the RNA polymerase II holoenzyme

Nature (London), 1995-03, Vol.374 (6518), p.193-196

1995

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IKKε Is Part of a Novel PMA-Inducible IκB Kinase Complex

Molecular cell, 2000-03, Vol.5 (3), p.513-522

2000

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Amount of Mononuclear Phagocyte Infiltrate Does Not Predict Area of Experimental Choroidal Neovascularization (CNV)

Journal of ocular pharmacology and therapeutics, 2018-09, Vol.34 (7), p.489

2018

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Validation of the Anti-Inflammatory Properties of Small-Molecule IκB Kinase (IKK)-2 Inhibitors by Comparison with Adenoviral-Mediated Delivery of Dominant-Negative IKK1 and IKK2 in Human Airways Smooth Muscle

Molecular pharmacology, 2006-08, Vol.70 (2), p.697-705

2006

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Ikkepsilon regulates viral-induced interferon regulatory factor-3 activation via a redox-sensitive pathway

Virology (New York, N.Y.), 2006-09, Vol.353 (1), p.155-165

2006

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Subunits shared by eukaryotic nuclear RNA polymerases

Genes & development, 1990-03, Vol.4 (3), p.313-323

1990

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RNA polymerase II subunit composition, stoichiometry, and phosphorylation

Molecular and Cellular Biology, 1990-05, Vol.10 (5), p.1915-1920

1990

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Association of an activator with an RNA polymerase II holoenzyme

Genes & development, 1995-04, Vol.9 (8), p.897-910

1995

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Corrigendum to “Ikkepsilon regulates viral-induced interferon regulatory factor-3 activation via a redox-sensitive pathway” [Virology 353 (2006) 155–165]

Virology (New York, N.Y.), 2007, Vol.357 (1), p.114-114

2007

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IKK and TBK1 are essential components of the IRF3 signaling pathway

Nature immunology, 2003-05, Vol.4 (5), p.491-496

2003

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IKKε and TBK1 are essential components of the IRF3 signaling pathway

Nature immunology, 2003-05, Vol.4 (5), p.491-496

2003

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Bacteriophage P22 Mnt repressor: DNA binding and effects on transcription in vitro

Journal of molecular biology, 1987-05, Vol.195 (2), p.311-322

1987

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Interaction of the bacteriophage P22 arc repressor with operator DNA

Journal of molecular biology, 1987-05, Vol.195 (2), p.323-331

1987

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Specific correlation between the major chromosome 10q26 haplotype conferring risk for age-related macular degeneration and the expression of HTRA1

Molecular vision, 2017, Vol.23, p.318-333

2017

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A proteogenomic signature of age-related macular degeneration in blood

Small-molecule factor B inhibitor for the treatment of complement-mediated diseases

Differential and Altered Spatial Distribution of Complement Expression in Age-Related Macular Degeneration

Temporal Regulation of RNA Polymerase II by Srb10 and Kin28 Cyclin-Dependent Kinases

Lack of involvement of CEP adducts in TLR activation and in angiogenesis

Small-molecule factor D inhibitors targeting the alternative complement pathway

Complement factor B is critical for sub-RPE deposit accumulation in a model of Doyne honeycomb retinal dystrophy with features of age-related macular degeneration

Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models

Discovery of 4-((2 S ,4 S )-4-Ethoxy-1-((5-methoxy-7-methyl-1 H -indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases

Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo

Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway

A kinase-cyclin pair in the RNA polymerase II holoenzyme

IKKε Is Part of a Novel PMA-Inducible IκB Kinase Complex

Amount of Mononuclear Phagocyte Infiltrate Does Not Predict Area of Experimental Choroidal Neovascularization (CNV)

Validation of the Anti-Inflammatory Properties of Small-Molecule IκB Kinase (IKK)-2 Inhibitors by Comparison with Adenoviral-Mediated Delivery of Dominant-Negative IKK1 and IKK2 in Human Airways Smooth Muscle

Ikkepsilon regulates viral-induced interferon regulatory factor-3 activation via a redox-sensitive pathway

Subunits shared by eukaryotic nuclear RNA polymerases

RNA polymerase II subunit composition, stoichiometry, and phosphorylation

Association of an activator with an RNA polymerase II holoenzyme

Corrigendum to “Ikkepsilon regulates viral-induced interferon regulatory factor-3 activation via a redox-sensitive pathway” [Virology 353 (2006) 155–165]

IKK and TBK1 are essential components of the IRF3 signaling pathway

IKKε and TBK1 are essential components of the IRF3 signaling pathway

Bacteriophage P22 Mnt repressor: DNA binding and effects on transcription in vitro

Interaction of the bacteriophage P22 arc repressor with operator DNA

Specific correlation between the major chromosome 10q26 haplotype conferring risk for age-related macular degeneration and the expression of HTRA1

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