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An overview of the pharmacological properties and potential applications of natural monoterpenes

Mini reviews in medicinal chemistry, 2014-01, Vol.14 (14), p.1156

2014

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The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity

Journal of medicinal chemistry, 2018-01, Vol.61 (1), p.119-139

2018

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Transient receptor potential channels - emerging novel drug targets for the treatment of pain

Current medicinal chemistry, 2013-04, Vol.20 (11), p.1409

2013

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Structure-activity relationship study of tryptophan-based butyrylcholinesterase inhibitors

European journal of medicinal chemistry, 2020-12, Vol.208, p.112766-112766, Article 112766

2020

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Nitrogen, oxygen or sulfur containing heterocyclic compounds as analgesic drugs used as modulators of the nitroxidative stress

Mini reviews in medicinal chemistry, 2013-03, Vol.13 (3), p.335

2013

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Synthesis and pharmacological evaluation of novel N-Mannich bases derived from 5,5-diphenyl and 5,5-di(propan-2-yl)imidazolidine-2,4-dione core

Bioorganic & medicinal chemistry letters, 2019-08, Vol.29 (16), p.2387-2392

2019

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GABA transporters as targets for new drugs

Future medicinal chemistry, 2011-02, Vol.3 (2), p.211

2011

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Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo

Bioorganic & medicinal chemistry, 2015-05, Vol.23 (10), p.2445-2457

2015

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Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, β-secretase, and amyloid β aggregation as potential treatment of Alzheimer's disease

European journal of medicinal chemistry, 2023-12, Vol.261, p.115832-115832, Article 115832

2023

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Discovery of new, highly potent and selective inhibitors of BuChE - design, synthesis, in vitro and in vivo evaluation and crystallography studies

European journal of medicinal chemistry, 2023-03, Vol.249, p.115135, Article 115135

2023

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Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT6R antagonists with β-amyloid anti-aggregation properties

European journal of medicinal chemistry, 2021-12, Vol.225, p.113792-113792, Article 113792

2021

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Searching for analgesic drug candidates alleviating oxaliplatin‐induced cold hypersensitivity in mice

Chemical biology & drug design, 2019-06, Vol.93 (6), p.1061-1072

2019

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Synthesis and anticonvulsant activities of novel 2-(cyclopentylmethylene)hydrazinyl-1,3-thiazoles in mouse models of seizures

Journal of enzyme inhibition and medicinal chemistry, 2016-11, Vol.31 (6), p.1576-1582

2016

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Studies on the Activity of Selected Highly Lipophilic Compounds toward hGAT1 Inhibition. Part II

ACS chemical neuroscience, 2019-01, Vol.10 (1), p.337-347

2019

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Development of tricyclic N-benzyl-4-hydroxybutanamide derivatives as inhibitors of GABA transporters mGAT1-4 with anticonvulsant, antinociceptive, and antidepressant activity

European journal of medicinal chemistry, 2021-10, Vol.221, p.113512-113512, Article 113512

2021

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Novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: A new approach for the treatment of pain

European journal of medicinal chemistry, 2018-10, Vol.158, p.517-533

2018

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Synthesis, anticonvulsant, and antinociceptive activity of new 3‐(3‐methyl‐2,5‐dioxo‐3‐phenylpyrrolidin‐1‐yl)propanamides and 3‐phenyl‐butanamides

Archiv der Pharmazie (Weinheim), 2021-01, Vol.354 (1), p.e2000225-n/a

2021

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Synthesis, and anticonvulsant activity of new amides derived from 3-methyl- or 3-ethyl-3-methyl-2,5-dioxo-pyrrolidin-1-yl-acetic acids

Bioorganic & medicinal chemistry, 2016-04, Vol.24 (8), p.1598-1607

2016

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Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice

European journal of medicinal chemistry, 2020-02, Vol.188, p.111920-111920, Article 111920

2020

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Anticonvulsant and analgesic in neuropathic pain activity in a group of new aminoalkanol derivatives

Bioorganic & medicinal chemistry letters, 2020-08, Vol.30 (16), p.127325, Article 127325

2020

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Thiazoles with cyclopropyl fragment as antifungal, anticonvulsant, and anti-Toxoplasma gondii agents: synthesis, toxicity evaluation, and molecular docking study

Medicinal chemistry research, 2018, Vol.27 (9), p.2125-2140

2018

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Synthesis, antimicrobial and anticonvulsant screening of small library of tetrahydro-2H-thiopyran-4-yl based thiazoles and selenazoles

Journal of enzyme inhibition and medicinal chemistry, 2016-11, Vol.31 (sup2), p.24-39

2016

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Novel Functionalized Amino Acids as Inhibitors of GABA Transporters with Analgesic Activity

ACS chemical neuroscience, 2021-08, Vol.12 (16), p.3073-3100

2021

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Synthesis and activity of di- or trisubstituted N-(phenoxyalkyl)- or N-{2-[2-(phenoxy)ethoxy]ethyl}piperazine derivatives on the central nervous system

Bioorganic & medicinal chemistry letters, 2018-06, Vol.28 (11), p.2039-2049

2018

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Synthesis, biological evaluation and structure–activity relationship of new GABA uptake inhibitors, derivatives of 4-aminobutanamides

European journal of medicinal chemistry, 2014-08, Vol.83, p.256-273

2014

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An overview of the pharmacological properties and potential applications of natural monoterpenes

The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity

Transient receptor potential channels - emerging novel drug targets for the treatment of pain

Structure-activity relationship study of tryptophan-based butyrylcholinesterase inhibitors

Nitrogen, oxygen or sulfur containing heterocyclic compounds as analgesic drugs used as modulators of the nitroxidative stress

Synthesis and pharmacological evaluation of novel N-Mannich bases derived from 5,5-diphenyl and 5,5-di(propan-2-yl)imidazolidine-2,4-dione core

GABA transporters as targets for new drugs

Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo

Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, β-secretase, and amyloid β aggregation as potential treatment of Alzheimer's disease

Discovery of new, highly potent and selective inhibitors of BuChE - design, synthesis, in vitro and in vivo evaluation and crystallography studies

Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT6R antagonists with β-amyloid anti-aggregation properties

Searching for analgesic drug candidates alleviating oxaliplatin‐induced cold hypersensitivity in mice

Synthesis and anticonvulsant activities of novel 2-(cyclopentylmethylene)hydrazinyl-1,3-thiazoles in mouse models of seizures

Studies on the Activity of Selected Highly Lipophilic Compounds toward hGAT1 Inhibition. Part II

Development of tricyclic N-benzyl-4-hydroxybutanamide derivatives as inhibitors of GABA transporters mGAT1-4 with anticonvulsant, antinociceptive, and antidepressant activity

Novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: A new approach for the treatment of pain

Synthesis, anticonvulsant, and antinociceptive activity of new 3‐(3‐methyl‐2,5‐dioxo‐3‐phenylpyrrolidin‐1‐yl)propanamides and 3‐phenyl‐butanamides

Synthesis, and anticonvulsant activity of new amides derived from 3-methyl- or 3-ethyl-3-methyl-2,5-dioxo-pyrrolidin-1-yl-acetic acids

Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice

Anticonvulsant and analgesic in neuropathic pain activity in a group of new aminoalkanol derivatives

Thiazoles with cyclopropyl fragment as antifungal, anticonvulsant, and anti-Toxoplasma gondii agents: synthesis, toxicity evaluation, and molecular docking study

Synthesis, antimicrobial and anticonvulsant screening of small library of tetrahydro-2H-thiopyran-4-yl based thiazoles and selenazoles

Novel Functionalized Amino Acids as Inhibitors of GABA Transporters with Analgesic Activity

Synthesis and activity of di- or trisubstituted N-(phenoxyalkyl)- or N-{2-[2-(phenoxy)ethoxy]ethyl}piperazine derivatives on the central nervous system

Synthesis, biological evaluation and structure–activity relationship of new GABA uptake inhibitors, derivatives of 4-aminobutanamides

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