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Antinociceptive and Antiallodynic Activity of Some 3-(3-Methylthiophen-2-yl)pyrrolidine-2,5-dione Derivatives in Mouse Models of Tonic and Neuropathic Pain

International journal of molecular sciences, 2022-04, Vol.23 (7), p.4057

2022

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Synthesis, Anticonvulsant, and Antinociceptive Activity of New 3-(2-Chlorophenyl)- and 3-(3-Chlorophenyl)-2,5-dioxo-pyrrolidin-1-yl-acetamides

Molecules (Basel, Switzerland), 2021-03, Vol.26 (6), p.1564

2021

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Synthesis, Anticonvulsant and Antinociceptive Activity of New Hybrid Compounds: Derivatives of 3-(3-Methylthiophen-2-yl)-pyrrolidine-2,5-dione

International journal of molecular sciences, 2020-08, Vol.21 (16), p.5750

2020

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Mechanochemical synthesis and anticonvulsant activity of 3-aminopyrrolidine-2,5-dione derivatives

Biomedicine & pharmacotherapy, 2023-12, Vol.168, p.115749-115749, Article 115749

2023

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The preliminary studies on protein profile in retained and not retained foetal membranes in heavy draft mares

Reproduction in domestic animals, 2019-12, Vol.54 (12), p.1543-1551

2019

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Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT₁A and 5-HT₇ Antagonists in Animal Models

PloS one, 2015-11, Vol.10 (11), p.e0142499-e0142499

2015

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The Search for New Anticonvulsants in a Group of (2,5-Dioxopyrrolidin-1-yl)(phenyl)Acetamides with Hybrid Structure-Synthesis and In Vivo/In Vitro Studies

International journal of molecular sciences, 2020-11, Vol.21 (22), p.8780

2020

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Identification of New Compounds with Anticonvulsant and Antinociceptive Properties in a Group of 3-substituted (2,5-dioxo-pyrrolidin-1-yl)(phenyl)-Acetamides

International journal of molecular sciences, 2021-12, Vol.22 (23), p.13092

2021

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ADVANCES AND LIMITATIONS IN PHARMACOTHERAPY OF EPILEPSY

Acta Poloniae pharmaceutica, 2018-10, Vol.75 (5), p.1069-1082

Rapacz, Anna

2018

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Major Histocompatibility Complex I Mediates Immunological Tolerance of the Trophoblast during Pregnancy and May Mediate Rejection during Parturition

Mediators of Inflammation, 2014-01, Vol.2014 (5), p.579279-11

2014

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Erratum to ＂Major Histocompatibility Complex I Mediates Immunological Tolerance of the Trophoblast during Pregnancy and May Mediate Rejection during Parturition

Mediators of Inflammation, 2014, Vol.2014 (8), p.1-1

2014

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The role of serotonergic, adrenergic and dopaminergic receptors in antidepressant-like effect

Pharmacological reports, 2016-04, Vol.68 (2), p.263-274

2016

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Synthesis and evaluation of anticonvulsant properties of new N-Mannich bases derived from pyrrolidine-2,5-dione and its 3-methyl-, 3-isopropyl, and 3-benzhydryl analogs

Bioorganic & medicinal chemistry letters, 2017-03, Vol.27 (6), p.1412-1415

2017

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KM-416, a novel phenoxyalkylaminoalkanol derivative with anticonvulsant properties exerts analgesic, local anesthetic, and antidepressant-like activities. Pharmacodynamic, pharmacokinetic, and forced degradation studies

European journal of pharmacology, 2020-11, Vol.886, p.173540, Article 173540

2020

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The role of placental immunological, pro-inflammatory, and proteolytic factors in the process of fetal membrane expulsion in mares

Medycyna weterynaryjna, 2021-10, Vol.77 (10), p.6577-2021

RAPACZ-LEONARD, ANNA

2021

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Design, synthesis and biological evaluation of new hybrid anticonvulsants derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide derivatives

Bioorganic & medicinal chemistry, 2015-05, Vol.23 (10), p.2548-2561

2015

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Analgesic and antiallodynic activity of novel anticonvulsant agents derived from 3-benzhydryl-pyrrolidine-2,5-dione in mouse models of nociceptive and neuropathic pain

European journal of pharmacology, 2020-02, Vol.869, p.172890, Article 172890

2020

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KA‐104, a new multitargeted anticonvulsant with potent antinociceptive activity in preclinical models

Epilepsia (Copenhagen), 2020-10, Vol.61 (10), p.2119-2128

2020

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Antidepressant-like activity of a new piperazine derivative of xanthone in the forced swim test in mice: The involvement of serotonergic system

Pharmacological reports, 2015-02, Vol.67 (1), p.160-165

2015

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HBK-14 and HBK-15, triple 5-HT1A, 5-HT7 and 5-HT3 antagonists with potent antidepressant- and anxiolytic-like properties, increase seizure threshold in various seizure tests in mice

Progress in neuro-psychopharmacology & biological psychiatry, 2017-10, Vol.79, p.378-385

2017

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Design, synthesis and anticonvulsant activity of new hybrid compounds derived from N-phenyl-2-(2,5-dioxopyrrolidin-1-yl)-propanamides and -butanamides

Bioorganic & medicinal chemistry, 2016-07, Vol.24 (13), p.2938-2946

2016

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Antiallodynic and antihyperalgesic activity of new 3,3-diphenyl-propionamides with anticonvulsant activity in models of pain in mice

European journal of pharmacology, 2018-02, Vol.821, p.39-48

2018

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Synthesis and pharmacological evaluation of novel N-Mannich bases derived from 5,5-diphenyl and 5,5-di(propan-2-yl)imidazolidine-2,4-dione core

Bioorganic & medicinal chemistry letters, 2019-08, Vol.29 (16), p.2387-2392

2019

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Evaluation of anticonvulsant and analgesic activity of new hybrid compounds derived from N-phenyl-2-(2,5-dioxopyrrolidin-1-yl)-propanamides and –butanamides

Epilepsy research, 2018-07, Vol.143, p.11-19

2018

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Anticonvulsant and antinociceptive activity of new amides derived from 3-phenyl-2,5-dioxo-pyrrolidine-1-yl-acetic acid in mice

European journal of pharmacology, 2016-06, Vol.781, p.239-249

2016

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Antinociceptive and Antiallodynic Activity of Some 3-(3-Methylthiophen-2-yl)pyrrolidine-2,5-dione Derivatives in Mouse Models of Tonic and Neuropathic Pain

Synthesis, Anticonvulsant, and Antinociceptive Activity of New 3-(2-Chlorophenyl)- and 3-(3-Chlorophenyl)-2,5-dioxo-pyrrolidin-1-yl-acetamides

Synthesis, Anticonvulsant and Antinociceptive Activity of New Hybrid Compounds: Derivatives of 3-(3-Methylthiophen-2-yl)-pyrrolidine-2,5-dione

Mechanochemical synthesis and anticonvulsant activity of 3-aminopyrrolidine-2,5-dione derivatives

The preliminary studies on protein profile in retained and not retained foetal membranes in heavy draft mares

Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT₁A and 5-HT₇ Antagonists in Animal Models

The Search for New Anticonvulsants in a Group of (2,5-Dioxopyrrolidin-1-yl)(phenyl)Acetamides with Hybrid Structure-Synthesis and In Vivo/In Vitro Studies

Identification of New Compounds with Anticonvulsant and Antinociceptive Properties in a Group of 3-substituted (2,5-dioxo-pyrrolidin-1-yl)(phenyl)-Acetamides

ADVANCES AND LIMITATIONS IN PHARMACOTHERAPY OF EPILEPSY

Major Histocompatibility Complex I Mediates Immunological Tolerance of the Trophoblast during Pregnancy and May Mediate Rejection during Parturition

Erratum to ＂Major Histocompatibility Complex I Mediates Immunological Tolerance of the Trophoblast during Pregnancy and May Mediate Rejection during Parturition

The role of serotonergic, adrenergic and dopaminergic receptors in antidepressant-like effect

Synthesis and evaluation of anticonvulsant properties of new N-Mannich bases derived from pyrrolidine-2,5-dione and its 3-methyl-, 3-isopropyl, and 3-benzhydryl analogs

KM-416, a novel phenoxyalkylaminoalkanol derivative with anticonvulsant properties exerts analgesic, local anesthetic, and antidepressant-like activities. Pharmacodynamic, pharmacokinetic, and forced degradation studies

The role of placental immunological, pro-inflammatory, and proteolytic factors in the process of fetal membrane expulsion in mares

Design, synthesis and biological evaluation of new hybrid anticonvulsants derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide derivatives

Analgesic and antiallodynic activity of novel anticonvulsant agents derived from 3-benzhydryl-pyrrolidine-2,5-dione in mouse models of nociceptive and neuropathic pain

KA‐104, a new multitargeted anticonvulsant with potent antinociceptive activity in preclinical models

Antidepressant-like activity of a new piperazine derivative of xanthone in the forced swim test in mice: The involvement of serotonergic system

HBK-14 and HBK-15, triple 5-HT1A, 5-HT7 and 5-HT3 antagonists with potent antidepressant- and anxiolytic-like properties, increase seizure threshold in various seizure tests in mice

Design, synthesis and anticonvulsant activity of new hybrid compounds derived from N-phenyl-2-(2,5-dioxopyrrolidin-1-yl)-propanamides and -butanamides

Antiallodynic and antihyperalgesic activity of new 3,3-diphenyl-propionamides with anticonvulsant activity in models of pain in mice

Synthesis and pharmacological evaluation of novel N-Mannich bases derived from 5,5-diphenyl and 5,5-di(propan-2-yl)imidazolidine-2,4-dione core

Evaluation of anticonvulsant and analgesic activity of new hybrid compounds derived from N-phenyl-2-(2,5-dioxopyrrolidin-1-yl)-propanamides and –butanamides

Anticonvulsant and antinociceptive activity of new amides derived from 3-phenyl-2,5-dioxo-pyrrolidine-1-yl-acetic acid in mice

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