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Discovery, Biological Evaluation, and Crystal Structure of a Novel Nanomolar Selective Butyrylcholinesterase Inhibitor

Journal of medicinal chemistry, 2014-10, Vol.57 (19), p.8167-8179

2014

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Development of an in-vivo active reversible butyrylcholinesterase inhibitor

Scientific reports, 2016-12, Vol.6 (1), p.39495-39495, Article 39495

2016

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Nonpeptidic Selective Inhibitors of the Chymotrypsin-Like (β5 i) Subunit of the Immunoproteasome

Angewandte Chemie (International ed.), 2016-05, Vol.55 (19), p.5745-5748

International ed. in English, 2016

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Nep1-like proteins as a target for plant pathogen control

PLoS pathogens, 2021-04, Vol.17 (4), p.e1009477-e1009477

2021

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Straightforward synthesis of orthogonally protected piperidin-3-ylmethanamine and piperidin-4-ylmethanamine derivatives

Tetrahedron letters, 2014-03, Vol.55 (12), p.2037-2039

2014

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Selective cytotoxicity of amidinopiperidine based compounds towards Burkitt's lymphoma cells involves proteasome inhibition

PloS one, 2012-07, Vol.7 (7), p.e41961-e41961

2012

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Discovery of novel small-molecule compounds with selective cytotoxicity for Burkitt's lymphoma cells using 3D ligand-based virtual screening

Molecules (Basel, Switzerland), 2014-11, Vol.19 (11), p.19209-19219

2014

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The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity

Journal of medicinal chemistry, 2018-01, Vol.61 (1), p.119-139

2018

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Isoindoline-1,3-dione derivatives targeting cholinesterases: Design, synthesis and biological evaluation of potential anti-Alzheimer’s agents

Bioorganic & medicinal chemistry, 2015-04, Vol.23 (7), p.1629-1637

2015

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N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer’s agents

Bioorganic & medicinal chemistry, 2017-01, Vol.25 (2), p.633-645

2017

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Aggressive conditions during primary drying as a contemporary approach to optimise freeze-drying cycles of biopharmaceuticals

European journal of pharmaceutical sciences, 2018-09, Vol.122, p.292-302

2018

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LiSiCA: A Software for Ligand-Based Virtual Screening and Its Application for the Discovery of Butyrylcholinesterase Inhibitors

Journal of chemical information and modeling, 2015-08, Vol.55 (8), p.1521-1528

2015

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The formation and effect of mannitol hemihydrate on the stability of monoclonal antibody in the lyophilized state

International journal of pharmaceutics, 2019-06, Vol.564, p.106-116

2019

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Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents

Bioorganic & medicinal chemistry, 2015-08, Vol.23 (15), p.4442-4452

2015

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Novel toll-like receptor 4 (TLR4) antagonists identified by structure- and ligand-based virtual screening

European journal of medicinal chemistry, 2013-12, Vol.70, p.393-399

2013

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Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo

Bioorganic & medicinal chemistry, 2015-05, Vol.23 (10), p.2445-2457

2015

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Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and β-amyloid aggregation inhibitors with neuroprotective properties

European journal of medicinal chemistry, 2015-03, Vol.92, p.738-749

2015

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Discovery of new MurA inhibitors using induced-fit simulation and docking

Bioorganic & medicinal chemistry letters, 2017-02, Vol.27 (4), p.944-949

2017

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Identification and characterization of the novel reversible and selective cathepsin X inhibitors

Scientific reports, 2017-09, Vol.7 (1), p.11459-11, Article 11459

2017

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Multiple Ligands Targeting Cholinesterases and β-Amyloid: Synthesis, Biological Evaluation of Heterodimeric Compounds with Benzylamine Pharmacophore

Archiv der Pharmazie (Weinheim), 2015-08, Vol.348 (8), p.556-563

2015

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Multiple Ligands Targeting Cholinesterases and [beta]-Amyloid: Synthesis, Biological Evaluation of Heterodimeric Compounds with Benzylamine Pharmacophore

Archiv der Pharmazie (Weinheim), 2015-08, Vol.348 (8), p.556

2015

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New enzymatic assay for the AKR1C enzymes

Chemico-biological interactions, 2013-02, Vol.202 (1-3), p.204-209

2013

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Expression of human aldo-keto reductase 1C2 in cell lines of peritoneal endometriosis: Potential implications in metabolism of progesterone and dydrogesterone and inhibition by progestins

The Journal of steroid biochemistry and molecular biology, 2012-05, Vol.130 (1-2), p.16-25

2012

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Synthetic tripeptides as alternate substrates of murein peptide ligase (Mpl)

Biochimie, 2013-06, Vol.95 (6), p.1120-1126

2013

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Discovery of highly potent, nonsteroidal 17β-hydroxysteroid dehydrogenase type 1 inhibitors by virtual high-throughput screening

The Journal of steroid biochemistry and molecular biology, 2011-11, Vol.127 (3), p.255-261

2011

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Discovery, Biological Evaluation, and Crystal Structure of a Novel Nanomolar Selective Butyrylcholinesterase Inhibitor

Development of an in-vivo active reversible butyrylcholinesterase inhibitor

Nonpeptidic Selective Inhibitors of the Chymotrypsin-Like (β5 i) Subunit of the Immunoproteasome

Nep1-like proteins as a target for plant pathogen control

Straightforward synthesis of orthogonally protected piperidin-3-ylmethanamine and piperidin-4-ylmethanamine derivatives

Selective cytotoxicity of amidinopiperidine based compounds towards Burkitt's lymphoma cells involves proteasome inhibition

Discovery of novel small-molecule compounds with selective cytotoxicity for Burkitt's lymphoma cells using 3D ligand-based virtual screening

The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity

Isoindoline-1,3-dione derivatives targeting cholinesterases: Design, synthesis and biological evaluation of potential anti-Alzheimer’s agents

N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer’s agents

Aggressive conditions during primary drying as a contemporary approach to optimise freeze-drying cycles of biopharmaceuticals

LiSiCA: A Software for Ligand-Based Virtual Screening and Its Application for the Discovery of Butyrylcholinesterase Inhibitors

The formation and effect of mannitol hemihydrate on the stability of monoclonal antibody in the lyophilized state

Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents

Novel toll-like receptor 4 (TLR4) antagonists identified by structure- and ligand-based virtual screening

Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo

Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and β-amyloid aggregation inhibitors with neuroprotective properties

Discovery of new MurA inhibitors using induced-fit simulation and docking

Identification and characterization of the novel reversible and selective cathepsin X inhibitors

Multiple Ligands Targeting Cholinesterases and β-Amyloid: Synthesis, Biological Evaluation of Heterodimeric Compounds with Benzylamine Pharmacophore

Multiple Ligands Targeting Cholinesterases and [beta]-Amyloid: Synthesis, Biological Evaluation of Heterodimeric Compounds with Benzylamine Pharmacophore

New enzymatic assay for the AKR1C enzymes

Expression of human aldo-keto reductase 1C2 in cell lines of peritoneal endometriosis: Potential implications in metabolism of progesterone and dydrogesterone and inhibition by progestins

Synthetic tripeptides as alternate substrates of murein peptide ligase (Mpl)

Discovery of highly potent, nonsteroidal 17β-hydroxysteroid dehydrogenase type 1 inhibitors by virtual high-throughput screening

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