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Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor

The New England journal of medicine, 2015-07, Vol.373 (5), p.428-437

2015

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Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study

Neuro-oncology (Charlottesville, Va.), 2016-04, Vol.18 (4), p.557-564

2016

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Phase Ib study of the combination of pexidartinib (PLX3397), a CSF-1R inhibitor, and paclitaxel in patients with advanced solid tumors

Therapeutic advances in medical oncology, 2019-06, Vol.11, p.1758835919854238

2019

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Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor

Proceedings of the National Academy of Sciences - PNAS, 2013-04, Vol.110 (14), p.5689-5694

2013

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Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent

Proceedings of the National Academy of Sciences - PNAS, 2009-01, Vol.106 (1), p.262-267

2009

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Structural Characterization of Autoinhibited C-Met Kinase Produced by Coexpression in Bacteria with Phosphatase

Proceedings of the National Academy of Sciences - PNAS, 2006-03, Vol.103 (10), p.3563-3568

2006

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Triiodothyronine Increases Brain Natriuretic Peptide (BNP) Gene Transcription and Amplifies Endothelin-dependent BNP Gene Transcription and Hypertrophy in Neonatal Rat Ventricular Myocytes

The Journal of biological chemistry, 2003-04, Vol.278 (17), p.15073-15083

2003

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TR Surfaces and Conformations Required to Bind Nuclear Receptor Corepressor

Molecular endocrinology (Baltimore, Md.), 2002-02, Vol.16 (2), p.271-286

2002

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RAF inhibitors that evade paradoxical MAPK pathway activation

Nature (London), 2015-10, Vol.526 (7574), p.583-586

2015

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BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor

Cancer discovery, 2018-04, Vol.8 (4), p.458-477

2018

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Discovery of a Selective Inhibitor of Oncogenic B-Raf Kinase with Potent Antimelanoma Activity

Proceedings of the National Academy of Sciences - PNAS, 2008-02, Vol.105 (8), p.3041-3046

2008

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A phase 2 study of orally administered PLX3397 in patients with recurrent glioblastoma

Journal of clinical oncology, 2014-05, Vol.32 (15_suppl), p.2023-2023

2014

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Abstract 552: Targeting brain tumors with PLX3397, an inhibitor of the CSF-1 receptor kinase

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.552-552

2011

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The Nuclear Receptor Corepressor (N-CoR) Contains Three Isoleucine Motifs (I/LXXII) That Serve as Receptor Interaction Domains (IDs)

Molecular endocrinology (Baltimore, Md.), 2000-12, Vol.14 (12), p.1976-1985

2000

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TR surfaces and conformations required to bind nuclear receptor corepressor

Molecular endocrinology (Baltimore, Md.), 2002-02, Vol.16 (2), p.271-286

2002

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Abstract 553: Discovery of novel TRK/FMS dual inhibitors as therapeutic candidates for pancreatic cancer

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.553-553

2011

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Abstract A229: BRAF inhibitors upregulate EGFR ligands: A molecular link to RAF inhibitor-induced cutaneous squamous cell carcinomas

Molecular cancer therapeutics, 2011-11, Vol.10 (11_Supplement), p.A229-A229

2011

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Design of thyroid hormone receptor antagonists from first principles

Journal of steroid biochemistry and molecular biology, 2002-12, Vol.83 (1), p.59-73

2002

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Renal calcium oxalate binding protein: Studies on its properties

Kidney international, 1998-01, Vol.53 (1), p.125-129

1998

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EFFECT OF CYCLOSPORIN A ON TISSUE LIPID PEROXIDATION AND MEMBRANE BOUND PHOSPHATASES IN HYPEROXALURIC RAT AND THE PROTECTION BY VITAMIN E PRETREATMENT

Japanese Journal of Medical Science and Biology, 1997, Vol.50(1), pp.9-17

1997

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Effect of Cyclosporin on Liver Antioxidants and the Protective Role of Vitamin E in Hyperoxaluria in Rats

Journal of pharmacy and pharmacology, 1998-05, Vol.50 (5), p.501-505

1998

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Effect of cyclosporin A treatment on renal calcium oxalate binding in experimental hyperoxaluria

Molecular and cellular biochemistry, 2002-07, Vol.236 (1-2), p.1-5

2002

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ERβ Binds N-CoR in the Presence of Estrogens via an LXXLL-like Motif in the N-CoR C-terminus

Nuclear receptor, 2003-06, Vol.1 (1), p.4-4, Article 4

2003

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Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor

Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study

Phase Ib study of the combination of pexidartinib (PLX3397), a CSF-1R inhibitor, and paclitaxel in patients with advanced solid tumors

Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor

Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent

Structural Characterization of Autoinhibited C-Met Kinase Produced by Coexpression in Bacteria with Phosphatase

Triiodothyronine Increases Brain Natriuretic Peptide (BNP) Gene Transcription and Amplifies Endothelin-dependent BNP Gene Transcription and Hypertrophy in Neonatal Rat Ventricular Myocytes

TR Surfaces and Conformations Required to Bind Nuclear Receptor Corepressor

RAF inhibitors that evade paradoxical MAPK pathway activation

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF -mutant melanoma

BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor

Discovery of a Selective Inhibitor of Oncogenic B-Raf Kinase with Potent Antimelanoma Activity

Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors: A Phase 1b/2a Nonrandomized Clinical Trial

A phase 2 study of orally administered PLX3397 in patients with recurrent glioblastoma

Abstract 552: Targeting brain tumors with PLX3397, an inhibitor of the CSF-1 receptor kinase

The Nuclear Receptor Corepressor (N-CoR) Contains Three Isoleucine Motifs (I/LXXII) That Serve as Receptor Interaction Domains (IDs)

TR surfaces and conformations required to bind nuclear receptor corepressor

Abstract 553: Discovery of novel TRK/FMS dual inhibitors as therapeutic candidates for pancreatic cancer

Abstract A229: BRAF inhibitors upregulate EGFR ligands: A molecular link to RAF inhibitor-induced cutaneous squamous cell carcinomas

Design of thyroid hormone receptor antagonists from first principles

Renal calcium oxalate binding protein: Studies on its properties

EFFECT OF CYCLOSPORIN A ON TISSUE LIPID PEROXIDATION AND MEMBRANE BOUND PHOSPHATASES IN HYPEROXALURIC RAT AND THE PROTECTION BY VITAMIN E PRETREATMENT

Effect of Cyclosporin on Liver Antioxidants and the Protective Role of Vitamin E in Hyperoxaluria in Rats

Effect of cyclosporin A treatment on renal calcium oxalate binding in experimental hyperoxaluria

ERβ Binds N-CoR in the Presence of Estrogens via an LXXLL-like Motif in the N-CoR C-terminus

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