UB Paderborn / Katalog / Suche / in CDI

Preclinical Pharmacokinetic Considerations for the Development of Antibody Drug Conjugates

Pharmaceutical research, 2015-11, Vol.32 (11), p.3470-3479

2015

Link zum Volltext

Verfügbarkeit prüfen

Translational pharmacokinetics and pharmacodynamics of monoclonal antibodies

Drug discovery today. Technologies, 2016-09, Vol.21-22, p.75-83

Kamath, Amrita V.

2016

Link zum Volltext

Verfügbarkeit prüfen

Sustained activity of novel THIOMAB antibody-antibiotic conjugate against Staphylococcus aureus in a mouse model: Longitudinal pharmacodynamic assessment by bioluminescence imaging

PloS one, 2019-10, Vol.14 (10), p.e0224096-e0224096

2019

Link zum Volltext

Verfügbarkeit prüfen

Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα)

Bioorganic & medicinal chemistry letters, 2020-02, Vol.30 (4), p.126907, Article 126907

2020

Link zum Volltext

Verfügbarkeit prüfen

Non-human primates in the PKPD evaluation of biologics: Needs and options to reduce, refine, and replace. A BioSafe White Paper

mAbs, 2022-12, Vol.14 (1), p.2145997

2022

Link zum Volltext

Verfügbarkeit prüfen

Characterization of Tissue Distribution, Catabolism, and Elimination of an Anti- Staphylococcus aureus THIOMAB Antibody-Antibiotic Conjugate in Rats

Drug metabolism and disposition, 2020-11, Vol.48 (11), p.1161-1168

2020

Link zum Volltext

Verfügbarkeit prüfen

Nonclinical Pharmacokinetics, Pharmacodynamics, and Translational Model of RO7297089, A Novel Anti-BCMA/CD16A Bispecific Tetravalent Antibody for the Treatment of Multiple Myeloma

The AAPS journal, 2022-09, Vol.24 (6), p.100, Article 100

2022

Link zum Volltext

Verfügbarkeit prüfen

Challenges and advances in the assessment of the disposition of antibody-drug conjugates

Biopharmaceutics & drug disposition, 2016-03, Vol.37 (2), p.66-74

2016

Link zum Volltext

Verfügbarkeit prüfen

A Phase 1, Randomized, Single-Ascending-Dose Study To Investigate the Safety, Tolerability, and Pharmacokinetics of DSTA4637S, an Anti- Staphylococcus aureus Thiomab Antibody-Antibiotic Conjugate, in Healthy Volunteers

Antimicrobial agents and chemotherapy, 2019-06, Vol.63 (6)

2019

Link zum Volltext

Verfügbarkeit prüfen

Imaging Reveals Importance of Shape and Flexibility for Glomerular Filtration of Biologics

Molecular cancer therapeutics, 2021-10, Vol.20 (10), p.2008-2015

2021

Link zum Volltext

Verfügbarkeit prüfen

Calicheamicin Antibody-Drug Conjugates with Improved Properties

Molecular cancer therapeutics, 2021-06, Vol.20 (6), p.1112-1120

2021

Link zum Volltext

Verfügbarkeit prüfen

Tensions in Teaching Senior Biology Using Inquiry Based Learning

Teaching science (Deakin West, A.C.T.), 2023-03, Vol.69 (1), p.29

2023

Link zum Volltext

Verfügbarkeit prüfen

Antibody Format and Serum Disposition Govern Ocular Pharmacokinetics of Intravenously Administered Protein Therapeutics

Frontiers in pharmacology, 2021-05, Vol.12, p.601569-601569

2021

Link zum Volltext

Verfügbarkeit prüfen

Valency of HER2 Targeting Antibodies Influences Tumor Cell Internalization and Penetration

Molecular cancer therapeutics, 2021-10, Vol.20 (10), p.1956-1965

2021

Link zum Volltext

Verfügbarkeit prüfen

Effect of molecular size on interstitial pharmacokinetics and tissue catabolism of antibodies

mAbs, 2022-12, Vol.14 (1), p.2085535-2085535

2022

Link zum Volltext

Verfügbarkeit prüfen

Influence of Charge, Hydrophobicity, and Size on Vitreous Pharmacokinetics of Large Molecules

Translational vision science & technology, 2019-11, Vol.8 (6), p.1

2019

Link zum Volltext

Verfügbarkeit prüfen

A Bispecific Modeling Framework Enables the Prediction of Efficacy, Toxicity, and Optimal Molecular Design of Bispecific Antibodies Targeting MerTK

The AAPS journal, 2024-01, Vol.26 (1), p.11-11, Article 11

2024

Link zum Volltext

Verfügbarkeit prüfen

Preclinical pharmacokinetics and in vitro metabolism of dasatinib (BMS-354825): a potent oral multi-targeted kinase inhibitor against SRC and BCR-ABL

Cancer chemotherapy and pharmacology, 2008-03, Vol.61 (3), p.365-376

2008

Link zum Volltext

Verfügbarkeit prüfen

Preclinical and translational pharmacokinetics of a novel THIOMAB™ antibody-antibiotic conjugate against Staphylococcus aureus

mAbs, 2019-08, Vol.11 (6), p.1162-1174

2019

Link zum Volltext

Verfügbarkeit prüfen

Balancing the Affinity and Pharmacokinetics of Antibodies by Modulating the Size of Charge Patches on Complementarity-Determining Regions

Journal of pharmaceutical sciences, 2020-12, Vol.109 (12), p.3690-3696

2020

Link zum Volltext

Verfügbarkeit prüfen

Preclinical pharmacokinetics of MHAA4549A, a human monoclonal antibody to influenza A virus, and the prediction of its efficacious clinical dose for the treatment of patients hospitalized with influenza A

mAbs, 2016-07, Vol.8 (5), p.991-997

2016

Link zum Volltext

Verfügbarkeit prüfen

Pharmacokinetics and pharmacodynamics of DSTA4637A: A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus in mice

mAbs, 2016-11, Vol.8 (8), p.1612-1619

2016

Link zum Volltext

Verfügbarkeit prüfen

Utilizing PK and PD Biomarkers to Guide the First-in-Human Starting Dose Selection of MTBT1466A: A Novel Humanized Monoclonal Anti-TGFβ3 Antibody for the Treatment of Fibrotic Diseases

Journal of pharmaceutical sciences, 2023-11, Vol.112 (11), p.2910-2920

2023

Link zum Volltext

Verfügbarkeit prüfen

Current Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Antibody-Drug Conjugates: An Industry White Paper

Drug metabolism and disposition, 2016-05, Vol.44 (5), p.617-623

2016

Link zum Volltext

Verfügbarkeit prüfen

Menü

Weitere Dienste

Einstellungen

Preclinical Pharmacokinetic Considerations for the Development of Antibody Drug Conjugates

Translational pharmacokinetics and pharmacodynamics of monoclonal antibodies

Sustained activity of novel THIOMAB antibody-antibiotic conjugate against Staphylococcus aureus in a mouse model: Longitudinal pharmacodynamic assessment by bioluminescence imaging

Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity

Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα)

Non-human primates in the PKPD evaluation of biologics: Needs and options to reduce, refine, and replace. A BioSafe White Paper

Characterization of Tissue Distribution, Catabolism, and Elimination of an Anti- Staphylococcus aureus THIOMAB Antibody-Antibiotic Conjugate in Rats

Nonclinical Pharmacokinetics, Pharmacodynamics, and Translational Model of RO7297089, A Novel Anti-BCMA/CD16A Bispecific Tetravalent Antibody for the Treatment of Multiple Myeloma

Challenges and advances in the assessment of the disposition of antibody-drug conjugates

A Phase 1, Randomized, Single-Ascending-Dose Study To Investigate the Safety, Tolerability, and Pharmacokinetics of DSTA4637S, an Anti- Staphylococcus aureus Thiomab Antibody-Antibiotic Conjugate, in Healthy Volunteers

Imaging Reveals Importance of Shape and Flexibility for Glomerular Filtration of Biologics

Calicheamicin Antibody-Drug Conjugates with Improved Properties

Tensions in Teaching Senior Biology Using Inquiry Based Learning

Antibody Format and Serum Disposition Govern Ocular Pharmacokinetics of Intravenously Administered Protein Therapeutics

Valency of HER2 Targeting Antibodies Influences Tumor Cell Internalization and Penetration

Effect of molecular size on interstitial pharmacokinetics and tissue catabolism of antibodies

Influence of Charge, Hydrophobicity, and Size on Vitreous Pharmacokinetics of Large Molecules

A Bispecific Modeling Framework Enables the Prediction of Efficacy, Toxicity, and Optimal Molecular Design of Bispecific Antibodies Targeting MerTK

Preclinical pharmacokinetics and in vitro metabolism of dasatinib (BMS-354825): a potent oral multi-targeted kinase inhibitor against SRC and BCR-ABL

Preclinical and translational pharmacokinetics of a novel THIOMAB™ antibody-antibiotic conjugate against Staphylococcus aureus

Balancing the Affinity and Pharmacokinetics of Antibodies by Modulating the Size of Charge Patches on Complementarity-Determining Regions

Preclinical pharmacokinetics of MHAA4549A, a human monoclonal antibody to influenza A virus, and the prediction of its efficacious clinical dose for the treatment of patients hospitalized with influenza A

Pharmacokinetics and pharmacodynamics of DSTA4637A: A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus in mice

Utilizing PK and PD Biomarkers to Guide the First-in-Human Starting Dose Selection of MTBT1466A: A Novel Humanized Monoclonal Anti-TGFβ3 Antibody for the Treatment of Fibrotic Diseases

Current Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Antibody-Drug Conjugates: An Industry White Paper

Suchergebnisse filtern