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Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP

Immunity (Cambridge, Mass.), 2020-02, Vol.52 (2), p.357-373.e9

2020

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Rapid identification of anti-idiotypic mAbs with high affinity and diverse epitopes by rabbit single B-cell sorting-culture and cloning technology

PloS one, 2020-12, Vol.15 (12), p.e0244158-e0244158

2020

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Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

Nature, 2006-12, Vol.444 (7122), p.1083-1087

2006

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Dramatic activation of an antibody by a single amino acid change in framework

Scientific reports, 2021-11, Vol.11 (1), p.22365-22365, Article 22365

2021

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An Anti-CLL-1 Antibody-Drug Conjugate for the Treatment of Acute Myeloid Leukemia

Clinical cancer research, 2019-02, Vol.25 (4), p.1358-1368

2019

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A novel, label‐free, pre‐equilibrium assay to determine the association and dissociation rate constants of therapeutic antibodies on living cells

British journal of pharmacology, 2023-11

2023

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Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy

Proceedings of the National Academy of Sciences - PNAS, 2020-05, Vol.117 (18), p.9952-9963

2020

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The homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell-cell adhesion

eLife, 2019-03, Vol.8

2019

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Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability

mAbs, 2024, Vol.16 (1), p.2309685-2309685

2024

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Harnessing MerTK agonism for targeted therapeutics

mAbs, 2020-01, Vol.12 (1), p.1685832-1685832

2020

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Cross-species Vascular Endothelial Growth Factor (VEGF)-blocking Antibodies Completely Inhibit the Growth of Human Tumor Xenografts and Measure the Contribution of Stromal VEGF

The Journal of biological chemistry, 2006-01, Vol.281 (2), p.951-961

2006

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Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding

The EMBO journal, 2007-11, Vol.26 (23), p.4902-4912

2007

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VEGF-null cells require PDGFR α signaling-mediated stromal fibroblast recruitment for tumorigenesis

The EMBO journal, 2004-07, Vol.23 (14), p.2800-2810

2004

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CLEC5a-directed bispecific antibody for effective cellular phagocytosis

mAbs, 2022, Vol.14 (1), p.2040083-2040083

2022

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EphB4 forward signalling regulates lymphatic valve development

Nature communications, 2015-04, Vol.6 (1), p.6625-6625, Article 6625

2015

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Isoform-selective TGF-β3 inhibition for systemic sclerosis

Med (New York, N.Y. : Online), 2024-02, Vol.5 (2), p.132-147.e7

2024

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Structural insight into distinct mechanisms of protease inhibition by antibodies

Proceedings of the National Academy of Sciences - PNAS, 2007-12, Vol.104 (50), p.19784-19789

2007

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A Real-Time Image-Based Efferocytosis Assay for the Discovery of Functionally Inhibitory Anti-MerTK Antibodies

The Journal of immunology (1950), 2023-04, Vol.210 (8), p.1166-1176

2023

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A Potent Pan-TGFβ Neutralizing Monoclonal Antibody Elicits Cardiovascular Toxicity in Mice and Cynomolgus Monkeys

Toxicological sciences, 2020-05, Vol.175 (1), p.24-34

2020

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Function Blocking Antibodies to Neuropilin-1 Generated from a Designed Human Synthetic Antibody Phage Library

Journal of molecular biology, 2007-02, Vol.366 (3), p.815-829

2007

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Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer

Frontiers in immunology, 2019-09, Vol.10, p.2019-2019

2019

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Influence of surface roughness of Bragg reflectors on resonance characteristics of solidly-mounted resonators

IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2007-04, Vol.54 (4), p.802-808

2007

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A Bispecific Modeling Framework Enables the Prediction of Efficacy, Toxicity, and Optimal Molecular Design of Bispecific Antibodies Targeting MerTK

The AAPS journal, 2024-01, Vol.26 (1), p.11-11, Article 11

2024

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Blocking Neuropilin-1 Function Has an Additive Effect with Anti-VEGF to Inhibit Tumor Growth

Cancer cell, 2007, Vol.11 (1), p.53-67

2007

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Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP

Rapid identification of anti-idiotypic mAbs with high affinity and diverse epitopes by rabbit single B-cell sorting-culture and cloning technology

Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

Dramatic activation of an antibody by a single amino acid change in framework

An Anti-CLL-1 Antibody-Drug Conjugate for the Treatment of Acute Myeloid Leukemia

A novel, label‐free, pre‐equilibrium assay to determine the association and dissociation rate constants of therapeutic antibodies on living cells

Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy

The homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell-cell adhesion

Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability

Harnessing MerTK agonism for targeted therapeutics

Cross-species Vascular Endothelial Growth Factor (VEGF)-blocking Antibodies Completely Inhibit the Growth of Human Tumor Xenografts and Measure the Contribution of Stromal VEGF

Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding

VEGF-null cells require PDGFR α signaling-mediated stromal fibroblast recruitment for tumorigenesis

CLEC5a-directed bispecific antibody for effective cellular phagocytosis

EphB4 forward signalling regulates lymphatic valve development

Isoform-selective TGF-β3 inhibition for systemic sclerosis

Structural insight into distinct mechanisms of protease inhibition by antibodies

A Real-Time Image-Based Efferocytosis Assay for the Discovery of Functionally Inhibitory Anti-MerTK Antibodies

A Potent Pan-TGFβ Neutralizing Monoclonal Antibody Elicits Cardiovascular Toxicity in Mice and Cynomolgus Monkeys

Function Blocking Antibodies to Neuropilin-1 Generated from a Designed Human Synthetic Antibody Phage Library

Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer

Influence of surface roughness of Bragg reflectors on resonance characteristics of solidly-mounted resonators

A Bispecific Modeling Framework Enables the Prediction of Efficacy, Toxicity, and Optimal Molecular Design of Bispecific Antibodies Targeting MerTK

Blocking Neuropilin-1 Function Has an Additive Effect with Anti-VEGF to Inhibit Tumor Growth

TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis

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