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Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

Nature biotechnology, 2012-02, Vol.30 (2), p.184-189

2012

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Conjugation Site Influences Antibody-Conjugated Drug PK Assays: Case Studies for Disulfide-Linked, Self-Immolating Next-Generation Antibody Drug Conjugates

Analytical chemistry (Washington), 2020-09, Vol.92 (18), p.12168-12175

2020

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Bioanalytical assay strategies for the development of antibody-drug conjugate biotherapeutics

Bioanalysis, 2013-01, Vol.5 (2), p.201

2013

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Characterization of intact antibody–drug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatography–mass spectrometry

Analytical biochemistry, 2011-05, Vol.412 (1), p.56-66

2011

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Multiplexed Quantitative Analysis of Antibody–Drug Conjugates with Labile CBI-Dimer Payloads In Vivo Using Immunoaffinity LC-MS/MS

Analytical chemistry (Washington), 2022-01, Vol.94 (2), p.1158-1168

2022

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Percutaneous Renal Biopsy in Egyptian Children: A Five-year Single-Center Experience

Saudi journal of kidney diseases and transplantation, 2022-01, Vol.33 (1), p.106-110

2022

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Development of a semi-automated MHC-associated peptide proteomics (MAPPs) method using streptavidin bead-based immunoaffinity capture and nano LC-MS/MS to support immunogenicity risk assessment in drug development

Frontiers in immunology, 2023, Vol.14, p.1295285-1295285

2023

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Method development of a novel PK assay for antibody-conjugated drug measurement of ADCs using peptide-linker drug analyte

Analytical and bioanalytical chemistry, 2019-05, Vol.411 (12), p.2587-2596

2019

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Immunogenicity of antibody-drug conjugates: observations across 8 molecules in 11 clinical trials

Bioanalysis, 2019-09, Vol.11 (17), p.1555

2019

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Clinical pharmacology of trastuzumab emtansine (T-DM1): an antibody–drug conjugate in development for the treatment of HER2-positive cancer

Cancer chemotherapy and pharmacology, 2012-05, Vol.69 (5), p.1229-1240

2012

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Hypoxia Attenuates Trastuzumab Uptake and Trastuzumab-Emtansine (T-DM1) Cytotoxicity through Redistribution of Phosphorylated Caveolin-1

Molecular cancer research, 2020-04, Vol.18 (4), p.644-656

2020

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Impact of Drug Conjugation on Pharmacokinetics and Tissue Distribution of Anti-STEAP1 Antibody–Drug Conjugates in Rats

Bioconjugate chemistry, 2011-10, Vol.22 (10), p.1994-2004

2011

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Minimal physiologically-based pharmacokinetic modeling of DSTA4637A, A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus, in a mouse model

mAbs, 2018-10, Vol.10 (7), p.1131-13

2018

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Catabolic fate and pharmacokinetic characterization of trastuzumab emtansine (T-DM1): an emphasis on preclinical and clinical catabolism

Current drug metabolism, 2012-09, Vol.13 (7), p.901

2012

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Compositional Analysis and Quantification of Heparin and Heparan Sulfate by Electrospray Ionization Ion Trap Mass Spectrometry

Analytical chemistry (Washington), 2003-07, Vol.75 (13), p.2985-2995

2003

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Preclinical Characterization of the Distribution, Catabolism, and Elimination of a Polatuzumab Vedotin-Piiq (POLIVY ® ) Antibody-Drug Conjugate in Sprague Dawley Rats

Journal of clinical medicine, 2021-03, Vol.10 (6), p.1323

2021

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Sustainable upgrading for informal areas

Alexandria engineering journal, 2019-03, Vol.58 (1), p.237-249

2019

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Delineating mechanisms of dissociation for isomeric heparin disaccharides using isotope labeling and ion trap tandem mass spectrometry

Journal of the American Society for Mass Spectrometry, 2004-09, Vol.15 (9), p.1274-1286

2004

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Semi-mechanistic Multiple-Analyte Pharmacokinetic Model for an Antibody-Drug-Conjugate in Cynomolgus Monkeys

Pharmaceutical research, 2015-06, Vol.32 (6), p.1907-1919

2015

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2023 White Paper on Recent Issues in Bioanalysis: ISR for ADA Assays, the Rise of dPCR vs qPCR, International Reference Standards for Vaccine Assays, Anti-AAV TAb Post-Dose Assessment, NanoString Validation, ELISpot as Gold Standard (Part 3 - Recommendations on Gene Therapy, Cell Therapy, Vaccines Immunogenicity & Technologies; Biotherapeutics Immunogenicity & Risk Assessment; ADA/NAb Assay/Reporting Harmonization)

Bioanalysis, 2024-04, Vol.16 (7), p.77

2024

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Development and Translational Application of an Integrated, Mechanistic Model of Antibody-Drug Conjugate Pharmacokinetics

The AAPS journal, 2017, Vol.19 (1), p.130-140

2017

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PK assays for antibody-drug conjugates: case study with ado-trastuzumab emtansine

Bioanalysis, 2013-05, Vol.5 (9), p.1025

2013

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Bioanalytical approaches for characterizing catabolism of antibody-drug conjugates

Bioanalysis, 2015-01, Vol.7 (13), p.1583

2015

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Heparin Sequencing Using Enzymatic Digestion and ESI-MSn with HOST: A Heparin/HS Oligosaccharide Sequencing Tool

Analytical chemistry (Washington), 2005-09, Vol.77 (18), p.5902-5911

2005

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Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

Conjugation Site Influences Antibody-Conjugated Drug PK Assays: Case Studies for Disulfide-Linked, Self-Immolating Next-Generation Antibody Drug Conjugates

Bioanalytical assay strategies for the development of antibody-drug conjugate biotherapeutics

Characterization of intact antibody–drug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatography–mass spectrometry

Multiplexed Quantitative Analysis of Antibody–Drug Conjugates with Labile CBI-Dimer Payloads In Vivo Using Immunoaffinity LC-MS/MS

Percutaneous Renal Biopsy in Egyptian Children: A Five-year Single-Center Experience

Development of a semi-automated MHC-associated peptide proteomics (MAPPs) method using streptavidin bead-based immunoaffinity capture and nano LC-MS/MS to support immunogenicity risk assessment in drug development

Method development of a novel PK assay for antibody-conjugated drug measurement of ADCs using peptide-linker drug analyte

Immunogenicity of antibody-drug conjugates: observations across 8 molecules in 11 clinical trials

Clinical pharmacology of trastuzumab emtansine (T-DM1): an antibody–drug conjugate in development for the treatment of HER2-positive cancer

Hypoxia Attenuates Trastuzumab Uptake and Trastuzumab-Emtansine (T-DM1) Cytotoxicity through Redistribution of Phosphorylated Caveolin-1

Impact of Drug Conjugation on Pharmacokinetics and Tissue Distribution of Anti-STEAP1 Antibody–Drug Conjugates in Rats

The HER2-directed antibody-drug conjugate DHES0815A in advanced and/or metastatic breast cancer: preclinical characterization and phase 1 trial results

Minimal physiologically-based pharmacokinetic modeling of DSTA4637A, A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus, in a mouse model

Catabolic fate and pharmacokinetic characterization of trastuzumab emtansine (T-DM1): an emphasis on preclinical and clinical catabolism

Compositional Analysis and Quantification of Heparin and Heparan Sulfate by Electrospray Ionization Ion Trap Mass Spectrometry

Preclinical Characterization of the Distribution, Catabolism, and Elimination of a Polatuzumab Vedotin-Piiq (POLIVY ® ) Antibody-Drug Conjugate in Sprague Dawley Rats

Sustainable upgrading for informal areas

Delineating mechanisms of dissociation for isomeric heparin disaccharides using isotope labeling and ion trap tandem mass spectrometry

Semi-mechanistic Multiple-Analyte Pharmacokinetic Model for an Antibody-Drug-Conjugate in Cynomolgus Monkeys

Development and Translational Application of an Integrated, Mechanistic Model of Antibody-Drug Conjugate Pharmacokinetics

PK assays for antibody-drug conjugates: case study with ado-trastuzumab emtansine

Bioanalytical approaches for characterizing catabolism of antibody-drug conjugates

Heparin Sequencing Using Enzymatic Digestion and ESI-MSn with HOST: A Heparin/HS Oligosaccharide Sequencing Tool

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