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Freshly Isolated Hepatocytes from Chimeric Humanized Liver Mice for the In Vitro Assessment of Drug Metabolism, Inhibition/Induction, and Safety Studies

Current protocols, 2022-05, Vol.2 (5), p.e429-n/a

Kakuni, Masakazu

2022

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Generation of Novel Chimeric Mice with Humanized Livers by Using Hemizygous cDNA-uPA/SCID Mice

PloS one, 2015-11, Vol.10 (11), p.e0142145

2015

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Identification of a novel long-acting 4’-modified nucleoside reverse transcriptase inhibitor against HBV

Journal of hepatology, 2021-05, Vol.74 (5), p.1075-1086

2021

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Chimeric mice with humanized livers: a unique tool for in vivo and in vitro enzyme induction studies

International journal of molecular sciences, 2013-12, Vol.15 (1), p.58-74

2013

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Lipoprotein profile and lipid metabolism of PXB-cells®, human primary hepatocytes from liver-humanized mice: proposal of novel in vitro system for screening anti-lipidemic drugs

Biomedical Research, 2020/02/01, Vol.41(1), pp.33-42

2020

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In Vitro Evaluation of Cytochrome P450 and Glucuronidation Activities in Hepatocytes Isolated from Liver-Humanized Mice

DRUG METABOLISM AND PHARMACOKINETICS, 2010-01, Vol.25 (6), p.539-550

2010

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Hepatitis B Virus Therapeutic Agent ARB-1740 Has Inhibitory Effect on Hepatitis Delta Virus in a New Dually-Infected Humanized Mouse Model

ACS infectious diseases, 2019-05, Vol.5 (5), p.738-749

2019

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Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis

Arthritis research & therapy, 2008-01, Vol.10 (4), p.R90-R90

2008

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PXB-cells for the study of lipid metabolism: robust and human-specific lipid profile in human hepatocytes freshly isolated from chimeric mice with humanized liver

Journal of hepatology, 2020-08, Vol.73, p.S294

2020

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THU319 - PXB-cells for the study of lipid metabolism: robust and human-specific lipid profile in human hepatocytes freshly isolated from chimeric mice with humanized liver

Journal of hepatology, 2020-08, Vol.73, p.S294-S294

2020

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Organic Anion-Transporting Polypeptide (OATP)-Mediated Drug-Drug Interaction Study between Rosuvastatin and Cyclosporine A in Chimeric Mice with Humanized Liver

Drug metabolism and disposition, 2018-01, Vol.46 (1), p.11-19

2018

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Predictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptide (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: integration with hepatic drug metabolism

Xenobiotica, 2020-11, Vol.50 (11), p.1370-1379

2020

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Novel pH-sensitive multifunctional envelope-type nanodevice for siRNA-based treatments for chronic HBV infection

Journal of hepatology, 2016-03, Vol.64 (3), p.547-555

2016

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Chimeric Mice With Humanized Livers Demonstrate Human-Specific Hepatotoxicity Caused by a Therapeutic Antibody Against TRAIL-Receptor 2/Death Receptor 5

Toxicological sciences, 2019-01, Vol.167 (1), p.190-201

2019

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Chimeric mice with human hepatocytes: A new system for genotoxicity studies

Mutation research. Genetic toxicology and environmental mutagenesis, 2019-03, Vol.839, p.9-12

2019

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Characterization and Prevention of Hypovitaminosis C in Chimeric Mice with Humanized Livers

Comparative medicine, 2022-12, Vol.72 (6), p.355-363

2022

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Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury

Toxicology letters, 2012-10, Vol.214 (1), p.9-18

2012

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Application of chimeric mice with humanized liver for study of human-specific drug metabolism

Drug metabolism and disposition, 2014-06, Vol.42 (6), p.1055

2014

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Investigation of drug-drug interactions caused by human pregnane X receptor-mediated induction of CYP3A4 and CYP2C subfamilies in chimeric mice with a humanized liver

Drug metabolism and disposition, 2012-03, Vol.40 (3), p.474

2012

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Morphological and microarray analyses of human hepatocytes from xenogeneic host livers

Laboratory investigation, 2013-01, Vol.93 (1), p.54-71

2013

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Characterization and Prevention of Hypovitaminosis C in Chimeric Mice with Humanized Livers

Comparative medicine, 2022-12, Vol.72 (6), p.355-363

2022

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Hepatitis C virus kinetics by administration of pegylated interferon-α in human and chimeric mice carrying human hepatocytes with variants of the IL28B gene

Gut, 2013-09, Vol.62 (9), p.1340-1346

2013

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Hepatitis C virus kinetics by administration of pegylated interferon-[alpha] in human and chimeric mice carrying human hepatocytes with variants of the IL28B gene

Gut, 2013-09, Vol.62 (9), p.1340

2013

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Hepatic IFN-Induced Protein with Tetratricopeptide Repeats Regulation of HCV Infection

Journal of interferon & cytokine research, 2019-03, Vol.39 (3), p.133

2019

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Predictability of metabolic activities of CYP2D6 substrates using chimeric mice transplanted with human hepatocytes

Drug metabolism and pharmacokinetics, 2017-01, Vol.32 (1), p.S41-S41

2017

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Freshly Isolated Hepatocytes from Chimeric Humanized Liver Mice for the In Vitro Assessment of Drug Metabolism, Inhibition/Induction, and Safety Studies

Generation of Novel Chimeric Mice with Humanized Livers by Using Hemizygous cDNA-uPA/SCID Mice

Identification of a novel long-acting 4’-modified nucleoside reverse transcriptase inhibitor against HBV

Chimeric mice with humanized livers: a unique tool for in vivo and in vitro enzyme induction studies

Lipoprotein profile and lipid metabolism of PXB-cells®, human primary hepatocytes from liver-humanized mice: proposal of novel in vitro system for screening anti-lipidemic drugs

In Vitro Evaluation of Cytochrome P450 and Glucuronidation Activities in Hepatocytes Isolated from Liver-Humanized Mice

Hepatitis B Virus Therapeutic Agent ARB-1740 Has Inhibitory Effect on Hepatitis Delta Virus in a New Dually-Infected Humanized Mouse Model

Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis

PXB-cells for the study of lipid metabolism: robust and human-specific lipid profile in human hepatocytes freshly isolated from chimeric mice with humanized liver

THU319 - PXB-cells for the study of lipid metabolism: robust and human-specific lipid profile in human hepatocytes freshly isolated from chimeric mice with humanized liver

Organic Anion-Transporting Polypeptide (OATP)-Mediated Drug-Drug Interaction Study between Rosuvastatin and Cyclosporine A in Chimeric Mice with Humanized Liver

Predictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptide (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: integration with hepatic drug metabolism

Novel pH-sensitive multifunctional envelope-type nanodevice for siRNA-based treatments for chronic HBV infection

Chimeric Mice With Humanized Livers Demonstrate Human-Specific Hepatotoxicity Caused by a Therapeutic Antibody Against TRAIL-Receptor 2/Death Receptor 5

Chimeric mice with human hepatocytes: A new system for genotoxicity studies

Characterization and Prevention of Hypovitaminosis C in Chimeric Mice with Humanized Livers

Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury

Application of chimeric mice with humanized liver for study of human-specific drug metabolism

Investigation of drug-drug interactions caused by human pregnane X receptor-mediated induction of CYP3A4 and CYP2C subfamilies in chimeric mice with a humanized liver

Morphological and microarray analyses of human hepatocytes from xenogeneic host livers

Characterization and Prevention of Hypovitaminosis C in Chimeric Mice with Humanized Livers

Hepatitis C virus kinetics by administration of pegylated interferon-α in human and chimeric mice carrying human hepatocytes with variants of the IL28B gene

Hepatitis C virus kinetics by administration of pegylated interferon-[alpha] in human and chimeric mice carrying human hepatocytes with variants of the IL28B gene

Hepatic IFN-Induced Protein with Tetratricopeptide Repeats Regulation of HCV Infection

Predictability of metabolic activities of CYP2D6 substrates using chimeric mice transplanted with human hepatocytes

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