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Generation of Novel Chimeric Mice with Humanized Livers by Using Hemizygous cDNA-uPA/SCID Mice

PloS one, 2015-11, Vol.10 (11), p.e0142145

2015

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Formation of the accumulative human metabolite and human-specific glutathione conjugate of diclofenac in TK-NOG chimeric mice with humanized livers

Drug metabolism and disposition, 2015-03, Vol.43 (3), p.309-316

2015

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Progressive loss of cortical acetylcholinesterase activity in association with cognitive decline in Alzheimer's disease: A positron emission tomography study

Annals of neurology, 2000-08, Vol.48 (2), p.194-200

2000

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Positron emission tomographic measurement of acetylcholinesterase activity reveals differential loss of ascending cholinergic systems in Parkinson's disease and progressive supranuclear palsy

Annals of neurology, 1999-07, Vol.46 (1), p.62-69

1999

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Acetylcholinesterase imaging: its use in therapy evaluation and drug design

Current pharmaceutical design, 2004-05, Vol.10 (13), p.1505

2004

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Estimation of plasma IC50 of donepezil hydrochloride for brain acetylcholinesterase inhibition in monkey using N-[11C]methylpiperidin-4-yl acetate ([11C]MP4A) and PET

Neuropsychopharmacology (New York, N.Y.), 2005-12, Vol.30 (12), p.2154-2161

2005

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Kinetic Analysis of [ C]MP4A Using a High-Radioactivity Brain Region That Represents an Integrated Input Function for Measurement of Cerebral Acetylcholinesterase Activity Without Arterial Blood Sampling

Journal of cerebral blood flow and metabolism, 2001-11, Vol.21 (11), p.1354-1366

2001

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A simple method for the detection of abnormal brain regions in Alzheimer's disease patients using [11C]MP4A: comparison with [123I]IMP SPECT

Annals of nuclear medicine, 2004-05, Vol.18 (3), p.187-193

2004

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Positron Emission Tomographic Measurement of Brain Acetylcholinesterase Activity Using N-[11C]methylpiperidin-4-yl Acetate Without Arterial Blood Sampling: Methodology of Shape Analysis and its Diagnostic Power for Alzheimer's Disease

Journal of cerebral blood flow and metabolism, 2001-03, Vol.21 (3), p.295-306

2001

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Synthesis of piperidinyl and pyrrolidinyl butyrates for potential In Vivo measurement of cerebral butyrylcholinesterase activity

Journal of labelled compounds & radiopharmaceuticals, 2001-01, Vol.44 (1), p.31-41

2001

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Human cerebral acetylcholinesterase activity measured with positron emission tomography: procedure, normal values and effect of age

European journal of nuclear medicine, 1999-02, Vol.26 (2), p.135-143

1999

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Brain Acetylcholinesterase Activity: Validation of a PET Tracer in a Rat Model of Alzheimer's Disease

The Journal of nuclear medicine (1978), 1996-04, Vol.37 (4), p.649-655

1996

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Evaluation of Simplified Kinetic Analyses for Measurement of Brain Acetylcholinesterase Activity Using N-[11C]Methylpiperidin-4-yl Propionate and Positron Emission Tomography

Journal of cerebral blood flow and metabolism, 2004-06, Vol.24 (6), p.600-611

2004

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Disposition of low doses of 14C-bisphenol A in male, female, pregnant, fetal, and neonatal rats

Archives of toxicology, 2005-05, Vol.79 (5), p.243-252

2005

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Positron emission tomography: quantitative measurement of brain acetylcholinesterase activity using radiolabeled substrates

Methods (San Diego, Calif.), 2002-07, Vol.27 (3), p.242-250

2002

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Brain acetylcholinesterase activity in Alzheimer disease measured by positron emission tomography

Alzheimer disease and associated disorders, 2000, Vol.14 (Supplement), p.S114-S118

2000

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Effects of irinotecan on hepatic gene expression in chimeric PXB-mouse® with highly humanized liver

Toxicology letters, 2014-09, Vol.229, p.S235-S235

2014

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Changes in hepatic gene expression induced by various statin formulations in chimeric PXB-Mouse® with highly humanized liver

Toxicology letters, 2013-08, Vol.221, p.S194-S194

2013

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Application of Bioimage Analyzer on Drug Metabolism Studies Using Thin Layer Chromatography (II): —Direct Development of Plasma Samples Containing [14C] Indomethacin and Its Metabolites

Drug Metabolism and Pharmacokinetics, 1993/12/30, Vol.8(6), pp.1273-1282

1993

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S15-6. Comprehensive Polymorphism Analysis of Drug Metabolism-related Genes by DMETTM Plus Premier Pack

Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics, 2010, Vol.41(3), pp.111S-112S

NAGATSUKA, Shin-Ichiro

2010

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N-methyl-3-(1-hydroxy-5-[123I]iodopent-4-enyl)-4-acetoxypiperidine, a novel candidate of acetylcholinesterase activity imaging agent

Journal of labelled compounds & radiopharmaceuticals, 2000-07, Vol.43 (8), p.753-765

2000

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Effect of donepezil on brain acetylcholinesterase activity in patients with AD measured by PET

Neurology, 2001-02, Vol.56 (3), p.408

2001

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Quantitative analysis of whole body autoradiogram using a computer-assisted image analyzer

Drug Metabolism and Pharmacokinetics, 1988, Vol.3(2), pp.121-135

1988

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Pharmacokinetics and metabolism of radiolabelled SNI-2011, a novel muscarinic receptor agonist, in healthy volunteers. Comprehensive understanding of absorption, metabolism and excretion using radiolabelled SNI-2011

Arzneimittel-Forschung, 2003, Vol.53 (2), p.80

2003

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Instruments for Radiation Measurement in Life Sciences (4): III. Quantitative Analysis of 14C in Biological Samples by Using Accelerator Mass Spectrometry

RADIOISOTOPES, 2003/05/15, Vol.52(5), pp.262-268

NAGATSUKA, Shin-ichiro

2003

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Generation of Novel Chimeric Mice with Humanized Livers by Using Hemizygous cDNA-uPA/SCID Mice

Formation of the accumulative human metabolite and human-specific glutathione conjugate of diclofenac in TK-NOG chimeric mice with humanized livers

Progressive loss of cortical acetylcholinesterase activity in association with cognitive decline in Alzheimer's disease: A positron emission tomography study

Positron emission tomographic measurement of acetylcholinesterase activity reveals differential loss of ascending cholinergic systems in Parkinson's disease and progressive supranuclear palsy

Acetylcholinesterase imaging: its use in therapy evaluation and drug design

Estimation of plasma IC50 of donepezil hydrochloride for brain acetylcholinesterase inhibition in monkey using N-[11C]methylpiperidin-4-yl acetate ([11C]MP4A) and PET

Kinetic Analysis of [ C]MP4A Using a High-Radioactivity Brain Region That Represents an Integrated Input Function for Measurement of Cerebral Acetylcholinesterase Activity Without Arterial Blood Sampling

A simple method for the detection of abnormal brain regions in Alzheimer's disease patients using [11C]MP4A: comparison with [123I]IMP SPECT

Positron Emission Tomographic Measurement of Brain Acetylcholinesterase Activity Using N-[11C]methylpiperidin-4-yl Acetate Without Arterial Blood Sampling: Methodology of Shape Analysis and its Diagnostic Power for Alzheimer's Disease

Synthesis of piperidinyl and pyrrolidinyl butyrates for potential In Vivo measurement of cerebral butyrylcholinesterase activity

Human cerebral acetylcholinesterase activity measured with positron emission tomography: procedure, normal values and effect of age

Brain Acetylcholinesterase Activity: Validation of a PET Tracer in a Rat Model of Alzheimer's Disease

Evaluation of Simplified Kinetic Analyses for Measurement of Brain Acetylcholinesterase Activity Using N-[11C]Methylpiperidin-4-yl Propionate and Positron Emission Tomography

Disposition of low doses of 14C-bisphenol A in male, female, pregnant, fetal, and neonatal rats

Positron emission tomography: quantitative measurement of brain acetylcholinesterase activity using radiolabeled substrates

Brain acetylcholinesterase activity in Alzheimer disease measured by positron emission tomography

Effects of irinotecan on hepatic gene expression in chimeric PXB-mouse® with highly humanized liver

Changes in hepatic gene expression induced by various statin formulations in chimeric PXB-Mouse® with highly humanized liver

Application of Bioimage Analyzer on Drug Metabolism Studies Using Thin Layer Chromatography (II): —Direct Development of Plasma Samples Containing [14C] Indomethacin and Its Metabolites

S15-6. Comprehensive Polymorphism Analysis of Drug Metabolism-related Genes by DMETTM Plus Premier Pack

N-methyl-3-(1-hydroxy-5-[123I]iodopent-4-enyl)-4-acetoxypiperidine, a novel candidate of acetylcholinesterase activity imaging agent

Effect of donepezil on brain acetylcholinesterase activity in patients with AD measured by PET

Quantitative analysis of whole body autoradiogram using a computer-assisted image analyzer

Pharmacokinetics and metabolism of radiolabelled SNI-2011, a novel muscarinic receptor agonist, in healthy volunteers. Comprehensive understanding of absorption, metabolism and excretion using radiolabelled SNI-2011

Instruments for Radiation Measurement in Life Sciences (4): III. Quantitative Analysis of 14C in Biological Samples by Using Accelerator Mass Spectrometry

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