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Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death

Nature communications, 2019-12, Vol.10 (1), p.5654-15, Article 5654

2019

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Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity

Nucleic acids research, 2023-10, Vol.51 (18), p.9920

2023

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Analysis of Plant-Plant Interactions Reveals the Presence of Potent Antileukemic Compounds

Molecules (Basel, Switzerland), 2022-05, Vol.27 (9), p.2928

2022

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Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets

Bioorganic & medicinal chemistry, 2015-05, Vol.23 (10), p.2328-2343

2015

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Synthesis, Crystallography, and Anti-Leukemic Activity of the Amino Adducts of Dehydroleucodine

Molecules (Basel, Switzerland), 2020-10, Vol.25 (20), p.4825

2020

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Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects

Antioxidants, 2023-11, Vol.12 (11), p.1987

2023

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466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator

Journal of clinical and translational science, 2023-04, Vol.7 (s1), p.136-137

2023

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Inhibitors of HGFA, Matriptase, and Hepsin Serine Proteases: A Nonkinase Strategy to Block Cell Signaling in Cancer

ACS medicinal chemistry letters, 2014-11, Vol.5 (11), p.1219-1224

2014

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Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (4), p.1114-1119

2013

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Nickel Complex Catalyzed Efficient Activation of sp3 and sp2 C–H Bonds for Alkylation and Arylation of Oxygen Containing Heterocyclic Molecules

Catalysis letters, 2014-03, Vol.144 (3), p.507-515

2014

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Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors

Progress in biophysics and molecular biology, 2021-08, Vol.163 (C), p.171-186

2021

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An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation

Progress in biophysics and molecular biology, 2021-08, Vol.163, p.143-159

2021

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Design, Parallel Synthesis, and Crystal Structures of Pyrazinone Antithrombotics as Selective Inhibitors of the Tissue Factor VIIa Complex

Journal of medicinal chemistry, 2003-09, Vol.46 (19), p.4050-4062

2003

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An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2

Methods in enzymology, 2021, Vol.661, p.407

2021

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Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor

DNA repair, 2017-12, Vol.60, p.29-39

2017

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GRB2 enforces homology-directed repair initiation by MRE11

Science advances, 2021-08, Vol.7 (32)

2021

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Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells

Journal of natural products (Washington, D.C.), 2016-04, Vol.79 (4), p.691-696

2016

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Applying HT-SAXS to chemical ligand screening

Methods in enzymology, 2023, Vol.678, p.331

2023

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Erratum to “Structure-activity relationships among DNA ligase inhibitors; characterization of a selective uncompetitive DNA ligase I inhibitor” [DNA Repair 60C (2017) 29–39]

DNA repair, 2018-01, Vol.61, p.99-99

2018

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A Novel Iron Complex for Cross-Coupling Reactions of Multiple C–Cl Bonds in Polychlorinated Solvents with Grignard Reagents

Catalysis letters, 2012-11, Vol.142 (11), p.1397-1404

2012

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Synthesis of a versatile 2 (1 H)-pyrazinone core for the preparation of Tissue Factor-Factor VIIa inhibitors

Tetrahedron, 2010-04, Vol.66 (14), p.2570-2581

2010

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Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex

Bioorganic & medicinal chemistry letters, 2003-07, Vol.13 (14), p.2319-2325

2003

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Vinyl Oxocarbenium Ions in Intermolecular [4 + 3] Cycloaddition Reactions

Journal of organic chemistry, 1997-03, Vol.62 (6), p.1578-1579

1997

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Nickel complex catalyzed efficient activation of [sp.sup.3] and [sp.sup.2] C-H bonds for alkylation and arylation of oxygen containing heterocyclic molecules

Catalysis letters, 2014-03, Vol.144 (3), p.507

2014

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Abstract LB-197: Hepatocyte Growth Factor Activator (HGFA) Inhibitors of c-MET/RON Kinase Signaling

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.LB-197-LB-197

2011

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Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death

Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity

Analysis of Plant-Plant Interactions Reveals the Presence of Potent Antileukemic Compounds

Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets

Synthesis, Crystallography, and Anti-Leukemic Activity of the Amino Adducts of Dehydroleucodine

Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects

466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator

Inhibitors of HGFA, Matriptase, and Hepsin Serine Proteases: A Nonkinase Strategy to Block Cell Signaling in Cancer

Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation

Nickel Complex Catalyzed Efficient Activation of sp3 and sp2 C–H Bonds for Alkylation and Arylation of Oxygen Containing Heterocyclic Molecules

Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors

An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation

Design, Parallel Synthesis, and Crystal Structures of Pyrazinone Antithrombotics as Selective Inhibitors of the Tissue Factor VIIa Complex

An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2

Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor

GRB2 enforces homology-directed repair initiation by MRE11

Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells

Applying HT-SAXS to chemical ligand screening

Erratum to “Structure-activity relationships among DNA ligase inhibitors; characterization of a selective uncompetitive DNA ligase I inhibitor” [DNA Repair 60C (2017) 29–39]

A Novel Iron Complex for Cross-Coupling Reactions of Multiple C–Cl Bonds in Polychlorinated Solvents with Grignard Reagents

Synthesis of a versatile 2 (1 H)-pyrazinone core for the preparation of Tissue Factor-Factor VIIa inhibitors

Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex

Vinyl Oxocarbenium Ions in Intermolecular [4 + 3] Cycloaddition Reactions

Nickel complex catalyzed efficient activation of [sp.sup.3] and [sp.sup.2] C-H bonds for alkylation and arylation of oxygen containing heterocyclic molecules

Abstract LB-197: Hepatocyte Growth Factor Activator (HGFA) Inhibitors of c-MET/RON Kinase Signaling

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