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Evolving SAXS versatility: solution X-ray scattering for macromolecular architecture, functional landscapes, and integrative structural biology

Current opinion in structural biology, 2019-10, Vol.58 (C), p.197-213

2019

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Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death

Nature communications, 2019-12, Vol.10 (1), p.5654-15, Article 5654

2019

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A Quantitative Assay Reveals Ligand Specificity of the DNA Scaffold Repair Protein XRCC1 and Efficient Disassembly of Complexes of XRCC1 and the Poly(ADP-ribose) Polymerase 1 by Poly(ADP-ribose) Glycohydrolase

The Journal of biological chemistry, 2015-02, Vol.290 (6), p.3775-3783

2015

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Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor

Structure (London), 2016-12, Vol.24 (12), p.2067-2079

2016

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Functional Dynamics in Replication Protein A DNA Binding and Protein Recruitment Domains

Structure (London), 2015-06, Vol.23 (6), p.1028-1038

2015

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Visualizing and accessing correlated SAXS data sets with Similarity Maps and Simple Scattering web resources

Methods in enzymology, 2023-01, Vol.678, p.411-440

2023

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Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors

Progress in biophysics and molecular biology, 2021-08, Vol.163 (C), p.171-186

2021

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A new structural framework for integrating replication protein A into DNA processing machinery

Nucleic acids research, 2013-02, Vol.41 (4), p.2313

2013

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Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities

Methods in enzymology, 2018, Vol.601, p.205-241

2018

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An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2

Methods in enzymology, 2021, Vol.661, p.407-431

2021

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What Combined Measurements From Structures and Imaging Tell Us About DNA Damage Responses

Methods in enzymology, 2017, Vol.592, p.417-455

2017

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Applying HT-SAXS to chemical ligand screening

Methods in enzymology, 2023, Vol.678, p.331-350

2023

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Structural Dynamics and Single-Stranded DNA Binding Activity of the Three N-Terminal Domains of the Large Subunit of Replication Protein A from Small Angle X-ray Scattering

Biochemistry (Easton), 2010-04, Vol.49 (13), p.2880-2889

2010

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NMR Analysis of the Architecture and Functional Remodeling of a Modular Multidomain Protein, RPA

Journal of the American Chemical Society, 2009-05, Vol.131 (18), p.6346-6347

2009

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Sample preparation methods to analyze DNA-induced structural changes in replication protein A

Methods in molecular biology (Clifton, N.J.), 2012, Vol.922, p.101

2012

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Human Deafness Mutation E385D Disrupts the Mechanochemical Coupling and Subcellular Targeting of Myosin-1a

Biophysical journal, 2008-01, Vol.94 (2), p.L05-L07

2008

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Preparation of the modular multi-domain protein RPA for study by NMR spectroscopy

Methods in molecular biology (Clifton, N.J.), 2012, Vol.831, p.181

2012

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Apoptosis-inducing factor: mechanistic insights and therapeutic opportunities from a metabolic allosteric switch

Acta crystallographica. Section A, Foundations and advances, 2019-07, Vol.75 (a1), p.a179-a179

2019

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Shape shifting in apoptosis-inducing factor allostery and interactions: switching between oxidative phosphorylation and cell death

Acta crystallographica. Section A, Foundations and advances, 2018-07, Vol.74 (a1), p.a14-a14

2018

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Functional dynamics in RPA DNA binding and protein recruitment domains

Structure (London), 2015-05, Vol.23 (6), p.1028-1038

2015

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Defining allostery and interactions regulating apoptosis-inducing factor

Acta crystallographica. Section A, Foundations and advances, 2017-05, Vol.73 (a1), p.a316-a316

2017

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NMR Analysis of the Architecture and Functional Remodeling of a Modular Multi-Domain Protein, RPA

Journal of the American Chemical Society, 2009-05, Vol.131 (18), p.6346-6347

2009

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Structural dynamics and ssDNA binding activity of the three N-terminal domains of the large subunit of Replication Protein A from small angle X-ray scattering

Biochemistry (Easton), 2010-04, Vol.49 (13), p.2880-2889

2010

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Incorporating HT-SAXS into drug-discovery pipelines

Acta crystallographica. Section A, Foundations and advances, 2020-08, Vol.76 (a1), p.a139-a139

2020

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Checkpoint Kinase ATR Promotes Nucleotide Excision Repair of UV-induced DNA Damage via Physical Interaction with Xeroderma Pigmentosum Group A

The Journal of biological chemistry, 2009-09, Vol.284 (36), p.24213-24222

2009

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Evolving SAXS versatility: solution X-ray scattering for macromolecular architecture, functional landscapes, and integrative structural biology

Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death

A Quantitative Assay Reveals Ligand Specificity of the DNA Scaffold Repair Protein XRCC1 and Efficient Disassembly of Complexes of XRCC1 and the Poly(ADP-ribose) Polymerase 1 by Poly(ADP-ribose) Glycohydrolase

Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor

Functional Dynamics in Replication Protein A DNA Binding and Protein Recruitment Domains

Visualizing and accessing correlated SAXS data sets with Similarity Maps and Simple Scattering web resources

Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors

A new structural framework for integrating replication protein A into DNA processing machinery

Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities

An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2

What Combined Measurements From Structures and Imaging Tell Us About DNA Damage Responses

Applying HT-SAXS to chemical ligand screening

Structural Dynamics and Single-Stranded DNA Binding Activity of the Three N-Terminal Domains of the Large Subunit of Replication Protein A from Small Angle X-ray Scattering

NMR Analysis of the Architecture and Functional Remodeling of a Modular Multidomain Protein, RPA

Sample preparation methods to analyze DNA-induced structural changes in replication protein A

Human Deafness Mutation E385D Disrupts the Mechanochemical Coupling and Subcellular Targeting of Myosin-1a

Preparation of the modular multi-domain protein RPA for study by NMR spectroscopy

Apoptosis-inducing factor: mechanistic insights and therapeutic opportunities from a metabolic allosteric switch

Shape shifting in apoptosis-inducing factor allostery and interactions: switching between oxidative phosphorylation and cell death

Functional dynamics in RPA DNA binding and protein recruitment domains

Defining allostery and interactions regulating apoptosis-inducing factor

NMR Analysis of the Architecture and Functional Remodeling of a Modular Multi-Domain Protein, RPA

Structural dynamics and ssDNA binding activity of the three N-terminal domains of the large subunit of Replication Protein A from small angle X-ray scattering

Incorporating HT-SAXS into drug-discovery pipelines

Checkpoint Kinase ATR Promotes Nucleotide Excision Repair of UV-induced DNA Damage via Physical Interaction with Xeroderma Pigmentosum Group A

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