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Activity‐based probes for the ubiquitin conjugation–deconjugation machinery: new chemistries, new tools, and new insights

The FEBS journal, 2017-05, Vol.284 (10), p.1555-1576

2017

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Antibody-Drug Conjugates for the Treatment of Cancer

Chemical biology & drug design, 2013-01, Vol.81 (1), p.113-121

2013

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Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates

Nature chemistry, 2016-12, Vol.8 (12), p.1112

2016

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Activity‐based probes for the multicatalytic proteasome

The FEBS journal, 2017-05, Vol.284 (10), p.1540-1554

2017

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Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

Journal of medicinal chemistry, 2012-05, Vol.55 (9), p.4101-4113

2012

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Modification of Cysteine-Substituted Antibodies Using Enzymatic Oxidative Coupling Reactions

Bioconjugate chemistry, 2023-03, Vol.34 (3), p.510-517

2023

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Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates

Chemical science (Cambridge), 2017-01, Vol.8 (1), p.366-370

2017

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Discovery of Peptidomimetic Antibody–Drug Conjugate Linkers with Enhanced Protease Specificity

Journal of medicinal chemistry, 2018-02, Vol.61 (3), p.989-1000

2018

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Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes

Nature communications, 2018-03, Vol.9 (1), p.1162-17, Article 1162

2018

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An Anti-CLL-1 Antibody-Drug Conjugate for the Treatment of Acute Myeloid Leukemia

Clinical cancer research, 2019-02, Vol.25 (4), p.1358-1368

2019

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In vivo bioluminescence imaging of labile iron in xenograft models and liver using FeAL-1, an iron-activatable form of D-luciferin

Cell chemical biology, 2023-11, Vol.30 (11), p.1468-1477.e6

2023

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Site-Specific Trastuzumab Maytansinoid Antibody–Drug Conjugates with Improved Therapeutic Activity through Linker and Antibody Engineering

Journal of medicinal chemistry, 2014-10, Vol.57 (19), p.7890-7899

2014

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Cyclodextrin Reduces Intravenous Toxicity of a Model Compound

Journal of pharmaceutical sciences, 2019-06, Vol.108 (6), p.1934-1943

2019

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Inhibiting caspase-6 activation and catalytic activity for neurodegenerative diseases

Current topics in medicinal chemistry, 2014-02, Vol.14 (3), p.319

2014

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Small-molecule pan-IAP antagonists: a patent review

Expert opinion on therapeutic patents, 2010-02, Vol.20 (2), p.251-267

2010

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Pyrrolobenzodiazepine Dimer Antibody–Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers

Journal of medicinal chemistry, 2017-12, Vol.60 (23), p.9490-9507

2017

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Antagonism of c-IAP and XIAP Proteins Is Required for Efficient Induction of Cell Death by Small-Molecule IAP Antagonists

ACS chemical biology, 2009-07, Vol.4 (7), p.557-566

2009

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Learning and confirming with preclinical studies: modeling and simulation in the discovery of GDC-0917, an inhibitor of apoptosis proteins antagonist

Drug metabolism and disposition, 2013-12, Vol.41 (12), p.2104

2013

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Design, Synthesis, and Biological Activity of a Potent Smac Mimetic That Sensitizes Cancer Cells to Apoptosis by Antagonizing IAPs

ACS chemical biology, 2006-09, Vol.1 (8), p.525-533

2006

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Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity

Journal of medicinal chemistry, 2011-03, Vol.54 (6), p.1914-1926

2011

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Toxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-α pharmacology

Toxicological sciences, 2013-01, Vol.131 (1), p.247-258

2013

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Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6

PloS one, 2012-12, Vol.7 (12), p.e50864-e50864

2012

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Activity‐based probes for the ubiquitin conjugation–deconjugation machinery: new chemistries, new tools, and new insights

Antibody-Drug Conjugates for the Treatment of Cancer

Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates

Novel antibody-antibiotic conjugate eliminates intracellular S. aureus

Activity‐based probes for the multicatalytic proteasome

Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

Modification of Cysteine-Substituted Antibodies Using Enzymatic Oxidative Coupling Reactions

Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates

Discovery of Peptidomimetic Antibody–Drug Conjugate Linkers with Enhanced Protease Specificity

Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes

An Anti-CLL-1 Antibody-Drug Conjugate for the Treatment of Acute Myeloid Leukemia

In vivo bioluminescence imaging of labile iron in xenograft models and liver using FeAL-1, an iron-activatable form of D-luciferin

Site-Specific Trastuzumab Maytansinoid Antibody–Drug Conjugates with Improved Therapeutic Activity through Linker and Antibody Engineering

Discovery of a Potent and Selective BCL‑XL Inhibitor with in Vivo Activity

Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody-Drug Conjugates with Self-Immolative Disulfide Linkers

Cyclodextrin Reduces Intravenous Toxicity of a Model Compound

Inhibiting caspase-6 activation and catalytic activity for neurodegenerative diseases

Small-molecule pan-IAP antagonists: a patent review

Pyrrolobenzodiazepine Dimer Antibody–Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers

Antagonism of c-IAP and XIAP Proteins Is Required for Efficient Induction of Cell Death by Small-Molecule IAP Antagonists

Learning and confirming with preclinical studies: modeling and simulation in the discovery of GDC-0917, an inhibitor of apoptosis proteins antagonist

Design, Synthesis, and Biological Activity of a Potent Smac Mimetic That Sensitizes Cancer Cells to Apoptosis by Antagonizing IAPs

Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity

Toxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-α pharmacology

Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6

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