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LRRK2 kinase in Parkinson's disease

Science (American Association for the Advancement of Science), 2018-04, Vol.360 (6384), p.36-37

2018

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Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease

Current opinion in cell biology, 2020-04, Vol.63, p.102-113

2020

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

Biochemical journal, 2008-12, Vol.416 (3), p.375-385

2008

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LKB1 and AMPK and the cancer-metabolism link - ten years after

BMC biology, 2013-04, Vol.11 (1), p.36-36, Article 36

2013

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The selectivity of protein kinase inhibitors: a further update

Biochemical journal, 2007-12, Vol.408 (3), p.297-315

2007

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Rab29 activation of the Parkinson's disease‐associated LRRK2 kinase

The EMBO journal, 2018-01, Vol.37 (1), p.1-18

2018

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The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling

PloS one, 2012-06, Vol.7 (6), p.e39132

2012

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Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

Nature communications, 2017-10, Vol.8 (1), p.830-14, Article 830

2017

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Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors

Biochemical journal, 2016-09, Vol.473 (17), p.2671-2685

2016

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Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis

eLife, 2017-11, Vol.6

2017

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Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2

Structure (London), 2020-04, Vol.28 (4), p.406-417.e6

2020

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The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters

Science signaling, 2014-07, Vol.7 (334), p.re3

2014

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LRRK2 activation in idiopathic Parkinson's disease

Science translational medicine, 2018-07, Vol.10 (451)

2018

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14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

Biochemical journal, 2010-09, Vol.430 (3), p.393-404

2010

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PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition

Cancer cell, 2016-08, Vol.30 (2), p.229-242

2016

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The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters

Biochemical journal, 2014-03, Vol.458 (3), p.559-573

2014

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Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors

Biochemical journal, 2013-06, Vol.452 (3), p.499-508

2013

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Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer

Cancer cell, 2013-03, Vol.23 (3), p.406-420

2013

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A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

eLife, 2018-11, Vol.7

2018

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Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

Biochemical journal, 2014-11, Vol.463 (3), p.413-427

2014

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Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

Biochemical journal, 2009-06, Vol.421 (1), p.29-42

2009

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Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells

Gastroenterology (New York, N.Y. 1943), 2012-06, Vol.142 (7), p.1504-1515.e3

2012

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Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites

Biochemical journal, 2021-01, Vol.478 (2), p.299-326

2021

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LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

Biochemical journal, 2007-07, Vol.405 (2), p.307-317

2007

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LRRK2 kinase in Parkinson's disease

Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

LKB1 and AMPK and the cancer-metabolism link - ten years after

The selectivity of protein kinase inhibitors: a further update

Rab29 activation of the Parkinson's disease‐associated LRRK2 kinase

The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis

Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2

The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters

LRRK2 activation in idiopathic Parkinson's disease

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters

Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors

Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer

A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells

Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

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