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Letrozole targets the human ether‐a‐go‐go–related gene potassium current in glioblastoma

Basic & clinical pharmacology & toxicology, 2021-03, Vol.128 (3), p.357-365

2021

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Predicting drug‐induced changes in QT interval and arrhythmias: QT‐shortening drugs point to gaps in the ICHS7B Guidelines

British journal of pharmacology, 2008-08, Vol.154 (7), p.1427-1438

2008

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Characterization of the novel mutant A78T-HERG from a long QT syndrome type 2 patient: Instability of the mutant protein and stabilization by heat shock factor 1

Journal of arrhythmia, 2016-10, Vol.32 (5), p.433-440

2016

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Classification Models for hERG Inhibitors by Counter-Propagation Neural Networks

Chemical biology & drug design, 2008-10, Vol.72 (4), p.279-289

2008

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Pentamidine reduces hERG expression to prolong the QT interval

British journal of pharmacology, 2005-05, Vol.145 (1), p.15-23

2005

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Development and validation of a method for the analysis of hydroxyzine hydrochloride in extracellular solution used in in vitro preclinical safety studies

Journal of pharmaceutical and biomedical analysis, 2015-11, Vol.115, p.69-73

2015

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IKr: The hERG Channel

Journal of molecular and cellular cardiology, 2001-05, Vol.33 (5), p.835-849

Tseng, Gea-Ny

2001

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Not All hERG Pore Domain Mutations Have a Severe Phenotype: G584S Has an Inactivation Gating Defect with Mild Phenotype Compared to G572S, Which Has a Dominant Negative Trafficking Defect and a Severe Phenotype

Journal of cardiovascular electrophysiology, 2009-08, Vol.20 (8), p.923-930

2009

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Blockade of the human ether-a-go-go-related gene potassium channel by ketamine

Journal of pharmacy and pharmacology, 2013-09, Vol.65 (9), p.1321-1328

2013

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Cholesterol modulates ion channels via down-regulation of phosphatidylinositol 4,5-bisphosphate

Journal of neurochemistry, 2010-03, Vol.112 (5), p.1286-1294

2010

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Hydroxyzine, a First Generation H1-Receptor Antagonist, Inhibits Human Ether-a-go-go–Related Gene (HERG) Current and Causes Syncope in a Patient With the HERG Mutation

Journal of Pharmacological Sciences, 2008, Vol.108(4), pp.462-471

2008

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A calibrated functional patch-clamp assay to enhance clinical variant interpretation in KCNH2-related long QT syndrome

American journal of human genetics, 2022-07, Vol.109 (7), p.1199-1207

2022

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A QSAR Model of hERG Binding Using a Large, Diverse, and Internally Consistent Training Set

Chemical biology & drug design, 2006-04, Vol.67 (4), p.284-296

2006

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L539 fs/47, a truncated mutation of human ether-a-go-go-related gene (hERG), decreases hERG ion channel currents in HEK 293 cells

Clinical and experimental pharmacology & physiology, 2013-01, Vol.40 (1), p.28-36

2013

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Screening for cardiac HERG potassium channel interacting proteins using the yeast two-hybrid technique

Cell biology international, 2014-02, Vol.38 (2), p.239-245

2014

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3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

Bioorganic & medicinal chemistry, 2019-04, Vol.27 (7), p.1292-1307

2019

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Blocking of the Human Ether-à-go-go-Related Gene Channel by Imatinib Mesylate

Biological and Pharmaceutical Bulletin, 2013/02/01, Vol.36(2), pp.268-275

2013

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Glycine/Serine Polymorphism at Position 38 Influences KCNE1 Subunit’s Modulatory Actions on Rapid and Slow Delayed Rectifier K+ Currents

Circulation Journal, 2014, Vol.78(3), pp.610-618

2014

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Cell-Based hERG Channel Inhibition Assay in High-Throughput Format

Methods in molecular biology (Clifton, N.J.), 2022, Vol.2474, p.21

2022

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Structure–Activity Relationship Studies Reveal New Astemizole Analogues Active against Plasmodium falciparum In Vitro

ACS medicinal chemistry letters, 2021-08, Vol.12 (8), p.1333-1341

2021

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Disruption of protein quality control of the human ether-à-go-go related gene K+ channel results in profound long QT syndrome

Heart rhythm, 2022-02, Vol.19 (2), p.281-292

2022

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Electrophysiologic, Pharmacokinetic, and Pharmacodynamic Values Indicating a Higher Risk of Torsades de Pointes

Journal of clinical pharmacology, 2011-06, Vol.51 (6), p.819-829

2011

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Electrophysiological Changes in the Rabbit Ventricular Wedge and Human-Induced Pluripotent Stem-Cell Derived (IPSC) Cardiomyocytes Translate to Severe Arrhythmia Observed in a Canine Toxicology Study, Not Predicted by Standard In Vitro Ion Channel Assays

International journal of toxicology, 2024-06, Vol.43 (3), p.231-242

2024

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Levels of Small Extracellular Vesicles Containing hERG-1 and Hsp47 as Potential Biomarkers for Cardiovascular Diseases

International journal of molecular sciences, 2024-05, Vol.25 (9), p.4913

2024

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Familial And Acquired Long QT Syndrome And The Cardiac Rapid Delayed Rectifier Potassium Current

Clinical and experimental pharmacology & physiology, 2000-10, Vol.27 (10), p.753-766

2000

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Letrozole targets the human ether‐a‐go‐go–related gene potassium current in glioblastoma

Predicting drug‐induced changes in QT interval and arrhythmias: QT‐shortening drugs point to gaps in the ICHS7B Guidelines

Characterization of the novel mutant A78T-HERG from a long QT syndrome type 2 patient: Instability of the mutant protein and stabilization by heat shock factor 1

Classification Models for hERG Inhibitors by Counter-Propagation Neural Networks

Pentamidine reduces hERG expression to prolong the QT interval

Development and validation of a method for the analysis of hydroxyzine hydrochloride in extracellular solution used in in vitro preclinical safety studies

IKr: The hERG Channel

Not All hERG Pore Domain Mutations Have a Severe Phenotype: G584S Has an Inactivation Gating Defect with Mild Phenotype Compared to G572S, Which Has a Dominant Negative Trafficking Defect and a Severe Phenotype

Blockade of the human ether-a-go-go-related gene potassium channel by ketamine

Cholesterol modulates ion channels via down-regulation of phosphatidylinositol 4,5-bisphosphate

Hydroxyzine, a First Generation H1-Receptor Antagonist, Inhibits Human Ether-a-go-go–Related Gene (HERG) Current and Causes Syncope in a Patient With the HERG Mutation

A calibrated functional patch-clamp assay to enhance clinical variant interpretation in KCNH2-related long QT syndrome

A QSAR Model of hERG Binding Using a Large, Diverse, and Internally Consistent Training Set

L539 fs/47, a truncated mutation of human ether-a-go-go-related gene (hERG), decreases hERG ion channel currents in HEK 293 cells

Screening for cardiac HERG potassium channel interacting proteins using the yeast two-hybrid technique

3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

Blocking of the Human Ether-à-go-go-Related Gene Channel by Imatinib Mesylate

Glycine/Serine Polymorphism at Position 38 Influences KCNE1 Subunit’s Modulatory Actions on Rapid and Slow Delayed Rectifier K+ Currents

Cell-Based hERG Channel Inhibition Assay in High-Throughput Format

Structure–Activity Relationship Studies Reveal New Astemizole Analogues Active against Plasmodium falciparum In Vitro

Disruption of protein quality control of the human ether-à-go-go related gene K+ channel results in profound long QT syndrome

Electrophysiologic, Pharmacokinetic, and Pharmacodynamic Values Indicating a Higher Risk of Torsades de Pointes

Electrophysiological Changes in the Rabbit Ventricular Wedge and Human-Induced Pluripotent Stem-Cell Derived (IPSC) Cardiomyocytes Translate to Severe Arrhythmia Observed in a Canine Toxicology Study, Not Predicted by Standard In Vitro Ion Channel Assays

Levels of Small Extracellular Vesicles Containing hERG-1 and Hsp47 as Potential Biomarkers for Cardiovascular Diseases

Familial And Acquired Long QT Syndrome And The Cardiac Rapid Delayed Rectifier Potassium Current

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