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Atomic structure of the APC/C and its mechanism of protein ubiquitination

Nature (London), 2015-06, Vol.522 (7557), p.450-454

2015

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Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming

Nature structural & molecular biology, 2020-06, Vol.27 (6), p.550-560

2020

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Molecular mechanism of APC/C activation by mitotic phosphorylation

Nature (London), 2016-05, Vol.533 (7602), p.260-264

2016

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Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division

Trends in cell biology, 2019-02, Vol.29 (2), p.117-134

2019

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RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex

Proceedings of the National Academy of Sciences - PNAS, 2015-04, Vol.112 (17), p.5272-5279

2015

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Molecular architecture and mechanism of the anaphase-promoting complex

Nature (London), 2014-09, Vol.513 (7518), p.388-393

2014

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Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site

Proceedings of the National Academy of Sciences - PNAS, 2019-08, Vol.116 (35), p.17280-17289

2019

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Cyclin-dependent kinase 1–dependent activation of APC/C ubiquitin ligase

Science (American Association for the Advancement of Science), 2016-05, Vol.352 (6289), p.1121-1124

2016

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Principles and dynamics of spindle assembly checkpoint signalling

Nature reviews. Molecular cell biology, 2023-08, Vol.24 (8), p.543-559

2023

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Building a Regulatory Network with Short Linear Sequence Motifs: Lessons from the Degrons of the Anaphase-Promoting Complex

Molecular cell, 2016-10, Vol.64 (1), p.12-23

2016

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Lactate regulates cell cycle by remodelling the anaphase promoting complex

Nature (London), 2023-04, Vol.616 (7958), p.790-797

2023

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Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1

Nature structural & molecular biology, 2011-01, Vol.18 (1), p.6-13

2011

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Molecular basis of APC/C regulation by the spindle assembly checkpoint

Nature (London), 2016-08, Vol.536 (7617), p.431-436

2016

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Ubiquitin signaling in cell cycle control and tumorigenesis

Cell death and differentiation, 2021-02, Vol.28 (2), p.427-438

2021

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Structural investigation of CDCA3‐Cdh1 protein–protein interactions using in vitro studies and molecular dynamics simulation

Protein science, 2023-03, Vol.32 (3), p.e4572-n/a

2023

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The Four Canonical TPR Subunits of Human APC/C Form Related Homo-Dimeric Structures and Stack in Parallel to Form a TPR Suprahelix

Journal of molecular biology, 2013-11, Vol.425 (22), p.4236-4248

2013

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TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC

Nature communications, 2018-10, Vol.9 (1), p.4354-11, Article 4354

2018

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Host-mediated ubiquitination of a mycobacterial protein suppresses immunity

Nature (London), 2020-01, Vol.577 (7792), p.682-688

2020

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APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability

Cancer discovery, 2017-02, Vol.7 (2), p.218-233

2017

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The Secret Life of the Inhibitor of Virus Replication

Viruses, 2022-12, Vol.14 (12), p.2782

2022

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Cezanne/OTUD7B is a cell cycle‐regulated deubiquitinase that antagonizes the degradation of APC/C substrates

The EMBO journal, 2018-08, Vol.37 (16), p.n/a

2018

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The Arabidopsis anaphase-promoting complex/cyclosome subunit 8 is required for male meiosis

The New phytologist, 2019-10, Vol.224 (1), p.229-241

2019

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A unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphase

EMBO reports, 2020-06, Vol.21 (6), p.e49831-n/a

2020

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Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I

The Journal of cell biology, 2019-05, Vol.218 (5), p.1553-1563

2019

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Role of phosphorylation of Cdc20 in the regulation of the action of APC/C in mitosis

Proceedings of the National Academy of Sciences - PNAS, 2022-08, Vol.119 (35), p.e2210367119

2022

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Atomic structure of the APC/C and its mechanism of protein ubiquitination

Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming

Molecular mechanism of APC/C activation by mitotic phosphorylation

Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division

RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex

Molecular architecture and mechanism of the anaphase-promoting complex

Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site

Cyclin-dependent kinase 1–dependent activation of APC/C ubiquitin ligase

Principles and dynamics of spindle assembly checkpoint signalling

Building a Regulatory Network with Short Linear Sequence Motifs: Lessons from the Degrons of the Anaphase-Promoting Complex

Lactate regulates cell cycle by remodelling the anaphase promoting complex

Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1

Molecular basis of APC/C regulation by the spindle assembly checkpoint

Ubiquitin signaling in cell cycle control and tumorigenesis

Structural investigation of CDCA3‐Cdh1 protein–protein interactions using in vitro studies and molecular dynamics simulation

The Four Canonical TPR Subunits of Human APC/C Form Related Homo-Dimeric Structures and Stack in Parallel to Form a TPR Suprahelix

TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC

Host-mediated ubiquitination of a mycobacterial protein suppresses immunity

APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability

The Secret Life of the Inhibitor of Virus Replication

Cezanne/OTUD7B is a cell cycle‐regulated deubiquitinase that antagonizes the degradation of APC/C substrates

The Arabidopsis anaphase-promoting complex/cyclosome subunit 8 is required for male meiosis

A unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphase

Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I

Role of phosphorylation of Cdc20 in the regulation of the action of APC/C in mitosis

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