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Orally Active 7‑Substituted (4-Benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as Active-Site Inhibitors of Sphingosine 1‑Phosphate Lyase for the Treatment of Multiple Sclerosis

Journal of medicinal chemistry, 2014-06, Vol.57 (12), p.5074-5084

2014

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Alternative Complement Pathway Inhibition Does Not Abrogate Meningococcal Killing by Serum of Vaccinated Individuals

Frontiers in immunology, 2021-10, Vol.12, p.747594-747594

2021

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Alternative Complement Pathway Inhibition Abrogates Pneumococcal Opsonophagocytosis in Vaccine-Naïve, but Not in Vaccinated Individuals

Frontiers in immunology, 2021-10, Vol.12, p.732146-732146

2021

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In vaccinated individuals serum bactericidal activity against B meningococci is abrogated by C5 inhibition but not by inhibition of the alternative complement pathway

Frontiers in immunology, 2023-06, Vol.14, p.1180833-1180833

2023

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Inhibition of the different complement pathways has varying impacts on the serum bactericidal activity and opsonophagocytosis against Haemophilus influenzae type b

Frontiers in immunology, 2022-12, Vol.13, p.1020580-1020580

2022

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Tesidolumab (LFG316) for treatment of C5-variant patients with paroxysmal nocturnal hemoglobinuria

Haematologica (Roma), 2022-06, Vol.107 (6), p.1483-1488

2022

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Antibody Cross-Reactivity between Myelin Oligodendrocyte Glycoprotein and the Milk Protein Butyrophilin in Multiple Sclerosis

The Journal of immunology (1950), 2004-01, Vol.172 (1), p.661-668

2004

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Inhibition of autoimmune encephalomyelitis by a tetracycline

Annals of neurology, 2002-02, Vol.51 (2), p.215-223

2002

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The next-generation sphingosine-1 receptor modulator BAF312 (siponimod) improves cortical network functionality in focal autoimmune encephalomyelitis

Neural regeneration research, 2019-11, Vol.14 (11), p.1950-1960

2019

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CD226 Is Specifically Expressed on the Surface of Th1 Cells and Regulates Their Expansion and Effector Functions

The Journal of immunology (1950), 2005-08, Vol.175 (3), p.1558-1565

2005

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Low‐molecular weight inhibitors of the alternative complement pathway

Immunological reviews, 2023-01, Vol.313 (1), p.339-357

2023

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Structural Insights into the Antigenicity of Myelin Oligodendrocyte Glycoprotein

Proceedings of the National Academy of Sciences - PNAS, 2003-08, Vol.100 (16), p.9446-9451

2003

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Commentary: Sorting the wheat from the chaff: identifying demyelinating components of the myelin oligodendrocyte glycoprotein (MOG)‐specific autoantibody repertoire

European journal of immunology, 2004-08, Vol.34 (8), p.2065-2071

2004

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Modelling paraneoplastic CNS disease: T-cells specific for the onconeuronal antigen PNMA1 mediate autoimmune encephalomyelitis in the rat

Brain (London, England : 1878), 2004-08, Vol.127 (8), p.1822-1830

2004

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The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures

Journal of neuroinflammation, 2016-02, Vol.13 (32), p.31-31, Article 31

2016

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Blood dilution reduces the efficacy of FB inhibitors to block zymosan-induced C5b-9 deposition

Molecular immunology, 2018-10, Vol.102, p.210-210

2018

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Siponimod (BAF312) prevents synaptic neurodegeneration in experimental multiple sclerosis

Journal of neuroinflammation, 2016-08, Vol.13 (1), p.207-207, Article 207

2016

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193 Iptacopan (LNP023) inhibits activity of FB mutants identified in patients with atypical hemolytic uremic syndrome (aHUS)

Immunobiology (1979), 2023-09, Vol.228 (5), p.152643, Article 152643

2023

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Small-molecule factor B inhibitor for the treatment of complement-mediated diseases

Proceedings of the National Academy of Sciences - PNAS, 2019-04, Vol.116 (16), p.7926-7931

2019

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The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity

Nature Immunology, 2005-12, Vol.6 (12), p.1245-1252

2005

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Siponimod Penetrates, Distributes and Acts on the Central Nervous System: Translational Insights (3973)

Neurology, 2020-04, Vol.94 (15_supplement)

2020

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Central nervous system-directed effects of FTY720 (fingolimod)

Journal of the neurological sciences, 2008-11, Vol.274 (1), p.13-17

2008

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MO042LNP023: A NOVEL ORAL COMPLEMENT ALTERNATIVE PATHWAY FACTOR B INHIBITOR FOR THE TREATMENT OF GLOMERULAR DISEASE

Nephrology, dialysis, transplantation, 2020-06, Vol.35 (Supplement_3)

2020

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Small-molecule factor D inhibitors targeting the alternative complement pathway

Nature chemical biology, 2016-12, Vol.12 (12), p.1105-1110

2016

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Effect of Subcutaneous vs Intravenous Chronic Treatment with an Anti-CD20 Antibody on B-, T- and Myeloid Lymphocyte Subsets in Blood, Lymph Nodes and Spleen of C57BL/6 Mice (P2.410)

Neurology, 2018-04, Vol.90 (15_supplement)

2018

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Orally Active 7‑Substituted (4-Benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as Active-Site Inhibitors of Sphingosine 1‑Phosphate Lyase for the Treatment of Multiple Sclerosis

Alternative Complement Pathway Inhibition Does Not Abrogate Meningococcal Killing by Serum of Vaccinated Individuals

Alternative Complement Pathway Inhibition Abrogates Pneumococcal Opsonophagocytosis in Vaccine-Naïve, but Not in Vaccinated Individuals

In vaccinated individuals serum bactericidal activity against B meningococci is abrogated by C5 inhibition but not by inhibition of the alternative complement pathway

Inhibition of the different complement pathways has varying impacts on the serum bactericidal activity and opsonophagocytosis against Haemophilus influenzae type b

Tesidolumab (LFG316) for treatment of C5-variant patients with paroxysmal nocturnal hemoglobinuria

Antibody Cross-Reactivity between Myelin Oligodendrocyte Glycoprotein and the Milk Protein Butyrophilin in Multiple Sclerosis

Inhibition of autoimmune encephalomyelitis by a tetracycline

The next-generation sphingosine-1 receptor modulator BAF312 (siponimod) improves cortical network functionality in focal autoimmune encephalomyelitis

CD226 Is Specifically Expressed on the Surface of Th1 Cells and Regulates Their Expansion and Effector Functions

Low‐molecular weight inhibitors of the alternative complement pathway

Structural Insights into the Antigenicity of Myelin Oligodendrocyte Glycoprotein

Commentary: Sorting the wheat from the chaff: identifying demyelinating components of the myelin oligodendrocyte glycoprotein (MOG)‐specific autoantibody repertoire

Modelling paraneoplastic CNS disease: T-cells specific for the onconeuronal antigen PNMA1 mediate autoimmune encephalomyelitis in the rat

The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures

Blood dilution reduces the efficacy of FB inhibitors to block zymosan-induced C5b-9 deposition

Siponimod (BAF312) prevents synaptic neurodegeneration in experimental multiple sclerosis

193 Iptacopan (LNP023) inhibits activity of FB mutants identified in patients with atypical hemolytic uremic syndrome (aHUS)

Small-molecule factor B inhibitor for the treatment of complement-mediated diseases

The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity

Siponimod Penetrates, Distributes and Acts on the Central Nervous System: Translational Insights (3973)

Central nervous system-directed effects of FTY720 (fingolimod)

MO042LNP023: A NOVEL ORAL COMPLEMENT ALTERNATIVE PATHWAY FACTOR B INHIBITOR FOR THE TREATMENT OF GLOMERULAR DISEASE

Small-molecule factor D inhibitors targeting the alternative complement pathway

Effect of Subcutaneous vs Intravenous Chronic Treatment with an Anti-CD20 Antibody on B-, T- and Myeloid Lymphocyte Subsets in Blood, Lymph Nodes and Spleen of C57BL/6 Mice (P2.410)

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