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PI3K inhibitors are finally coming of age

Nature reviews. Drug discovery, 2021-10, Vol.20 (10), p.741-769

2021

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Design, Synthesis, and Biological Evaluation of MEK PROTACs

Journal of medicinal chemistry, 2020-01, Vol.63 (1), p.157-162

2020

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Author Correction: PI3K inhibitors are finally coming of age

Nature reviews. Drug discovery, 2021-10, Vol.20 (10), p.798-798

2021

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Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Journal of medicinal chemistry, 2014-03, Vol.57 (6), p.2746-2754

2014

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Structural and conformational determinants of macrocycle cell permeability

Nature chemical biology, 2016-12, Vol.12 (12), p.1065-1074

2016

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Evolution of PI3Kγ and δ Inhibitors for Inflammatory and Autoimmune Diseases

Journal of medicinal chemistry, 2019-05, Vol.62 (10), p.4783-4814

2019

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Stabilization of protein-protein interactions in drug discovery

Expert opinion on drug discovery, 2017-09, Vol.12 (9), p.925-940

2017

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A class of highly selective inhibitors bind to an active state of PI3Kγ

Nature chemical biology, 2019-04, Vol.15 (4), p.348-357

2019

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Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3‑Kinase (PI3K)‑γ Inhibitors

Journal of medicinal chemistry, 2018-06, Vol.61 (12), p.5435-5441

2018

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Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092

Bioorganic & medicinal chemistry letters, 2012-11, Vol.22 (21), p.6694-6699

2012

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Discovery of AZD8154, a Dual PI3Kγδ Inhibitor for the Treatment of Asthma

Journal of medicinal chemistry, 2021-06, Vol.64 (12), p.8053-8075

2021

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Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein–Protein Interaction

ACS chemical biology, 2020-04, Vol.15 (4), p.1026-1035

2020

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Design and Synthesis of Soluble and Cell-Permeable PI3Kδ Inhibitors for Long-Acting Inhaled Administration

Journal of medicinal chemistry, 2017-06, Vol.60 (12), p.5057-5071

2017

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Localization of cerebral activity during simple singing

Neuroreport, 1999-12, Vol.10 (18), p.3979-3984

1999

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Spiro-fused Pyrrolidine, Piperidine, and Oxindole Scaffolds from Lactams

Organic letters, 2012-09, Vol.14 (18), p.4846-4849

2012

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14-3-3 modulation of the inflammatory response

Pharmacological research, 2021-01, Vol.163, p.105236-105236, Article 105236

2021

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Designing novel building blocks is an overlooked strategy to improve compound quality

Drug discovery today, 2015-01, Vol.20 (1), p.11-17

2015

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Surprising lipophilicity observations identify unexpected conformational effects

Bioorganic & medicinal chemistry letters, 2022-08, Vol.69, p.128786, Article 128786

2022

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Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators

The Journal of biological chemistry, 2021-01, Vol.296, p.100551-100551, Article 100551

2021

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Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3‑3 Protein–Protein Interaction

Journal of medicinal chemistry, 2022-12, Vol.65 (24), p.16818-16828

2022

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Magnetic source imaging of late evoked field responses to vowels: toward an assessment of hemispheric dominance for language

Journal of neurosurgery, 2001-03, Vol.94 (3), p.445-453

2001

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Localization of cerebral activity during simple singing

Neuroreport, 1999-11, Vol.10 (16), p.3453-3458

1999

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Manifestations of depression in people with intellectual disability

Journal of intellectual disability research, 1997-12, Vol.41 (6), p.476-480

1997

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Correction to “Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3‑3 Protein–Protein Interaction”

Journal of medicinal chemistry, 2023-02, Vol.66 (3), p.2205-2207

2023

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A fully implantable rodent neural stimulator

Journal of neural engineering, 2012-02, Vol.9 (1), p.014001-1-17

2012

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PI3K inhibitors are finally coming of age

Design, Synthesis, and Biological Evaluation of MEK PROTACs

Author Correction: PI3K inhibitors are finally coming of age

Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Structural and conformational determinants of macrocycle cell permeability

Evolution of PI3Kγ and δ Inhibitors for Inflammatory and Autoimmune Diseases

Stabilization of protein-protein interactions in drug discovery

A class of highly selective inhibitors bind to an active state of PI3Kγ

Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3‑Kinase (PI3K)‑γ Inhibitors

Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092

Discovery of AZD8154, a Dual PI3Kγδ Inhibitor for the Treatment of Asthma

Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein–Protein Interaction

Design and Synthesis of Soluble and Cell-Permeable PI3Kδ Inhibitors for Long-Acting Inhaled Administration

Localization of cerebral activity during simple singing

Spiro-fused Pyrrolidine, Piperidine, and Oxindole Scaffolds from Lactams

14-3-3 modulation of the inflammatory response

Designing novel building blocks is an overlooked strategy to improve compound quality

Surprising lipophilicity observations identify unexpected conformational effects

Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators

Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3‑3 Protein–Protein Interaction

Magnetic source imaging of late evoked field responses to vowels: toward an assessment of hemispheric dominance for language

Localization of cerebral activity during simple singing

Manifestations of depression in people with intellectual disability

Correction to “Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3‑3 Protein–Protein Interaction”

A fully implantable rodent neural stimulator

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