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Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex

Nature chemical biology, 2020-01, Vol.16 (1), p.15

2020

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The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer

Cancer discovery, 2014-06, Vol.4 (6), p.662-673

2014

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Target-Based Identification and Optimization of 5‑Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay

Journal of medicinal chemistry, 2020-08, Vol.63 (15), p.8276-8295

2020

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Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain

Biochemical journal, 2010-09, Vol.430 (3), p.425-437

2010

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Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors

Nature (London), 2016-06, Vol.534 (7605), p.129-132

2016

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Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro- N 2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)- N 4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials

Journal of medicinal chemistry, 2013-07, Vol.56 (14), p.5675-5690

2013

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NMR Structural Studies of Interactions of a Small, Nonpeptidyl Tpo Mimic with the Thrombopoietin Receptor Extracellular Juxtamembrane and Transmembrane Domains

The Journal of biological chemistry, 2007-05, Vol.282 (19), p.14253-14261

2007

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Discovery of small molecules that target a tertiary-structured RNA

Proceedings of the National Academy of Sciences - PNAS, 2022-11, Vol.119 (48), p.e2213117119

2022

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Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology

Journal of medicinal chemistry, 2021-04, Vol.64 (8), p.4857-4869

2021

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Discovery of potent, orally bioavailable in vivo efficacious antagonists of the TLR7/8 pathway

Bioorganic & medicinal chemistry letters, 2020-09, Vol.30 (17), p.127366-127366, Article 127366

2020

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Discovery of the TLR7/8 Antagonist MHV370 for Treatment of Systemic Autoimmune Diseases

ACS medicinal chemistry letters, 2023-08, Vol.14 (8), p.1054-1062

2023

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Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases

ACS medicinal chemistry letters, 2017-10, Vol.8 (10), p.1048-1053

2017

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Discovery of Orally Active Hydroxyethylamine Based SPPL2a Inhibitors

ACS medicinal chemistry letters, 2019-06, Vol.10 (6), p.887-892

2019

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Design and synthesis of novel selective anaplastic lymphoma kinase inhibitors

Bioorganic & medicinal chemistry letters, 2016-02, Vol.26 (3), p.1090-1096

2016

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Syk inhibitors with high potency in presence of blood

Bioorganic & medicinal chemistry letters, 2014-05, Vol.24 (10), p.2278-2282

2014

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Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors

Bioorganic & medicinal chemistry letters, 2016-04, Vol.26 (8), p.2057-2064

2016

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A Facile Cycloisomerization for the Formation of Medium and Large Rings via Allenes

Angewandte Chemie (International ed.), 1997-09, Vol.36 (16), p.1750-1753

1997

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Design, Synthesis, and Structure−Activity Relationship Studies of Novel 6,7-Locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic Acids

Journal of medicinal chemistry, 2003-09, Vol.46 (19), p.4087-4103

2003

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Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists

Bioorganic & medicinal chemistry letters, 2014-12, Vol.24 (23), p.5478-5483

2014

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Discovery of structurally novel, potent and orally efficacious GPR119 agonists

Bioorganic & medicinal chemistry letters, 2014-05, Vol.24 (10), p.2383-2387

2014

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Design, synthesis and structure–activity relationship of novel RXR-selective modulators

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (6), p.1593-1598

2004

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Regiochemistry of Wacker-type oxidation of vinyl group in the presence of neighboring oxygen functions. Part 1

Tetrahedron, 1997-06, Vol.53 (22), p.7577-7586

1997

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Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex

The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer

EGF816 Exerts Anticancer Effects in Non-Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor

Target-Based Identification and Optimization of 5‑Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay

Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain

Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors

NMR Structural Studies of Interactions of a Small, Nonpeptidyl Tpo Mimic with the Thrombopoietin Receptor Extracellular Juxtamembrane and Transmembrane Domains

Discovery of small molecules that target a tertiary-structured RNA

Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology

Discovery of potent, orally bioavailable in vivo efficacious antagonists of the TLR7/8 pathway

Biological Characterization of a Heterodimer-Selective Retinoid X Receptor Modulator: Potential Benefits for the Treatment of Type 2 Diabetes

Discovery of the TLR7/8 Antagonist MHV370 for Treatment of Systemic Autoimmune Diseases

Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases

Discovery of Orally Active Hydroxyethylamine Based SPPL2a Inhibitors

Design and synthesis of novel selective anaplastic lymphoma kinase inhibitors

Syk inhibitors with high potency in presence of blood

Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors

A Facile Cycloisomerization for the Formation of Medium and Large Rings via Allenes

Design, Synthesis, and Structure−Activity Relationship Studies of Novel 6,7-Locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic Acids

Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists

Discovery of structurally novel, potent and orally efficacious GPR119 agonists

Design, synthesis and structure–activity relationship of novel RXR-selective modulators

Regiochemistry of Wacker-type oxidation of vinyl group in the presence of neighboring oxygen functions. Part 1

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